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Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00031; UER00012.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferaseUniRule annotation (EC:2.6.1.9UniRule annotation)
Alternative name(s):
Imidazole acetol-phosphate transaminaseUniRule annotation
Gene namesi
Name:hisCUniRule annotation
Ordered Locus Names:VNG_1033G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001534931 – 366Histidinol-phosphate aminotransferaseAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ9HQS0.
PRIDEiQ9HQS0.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1033G.

Structurei

3D structure databases

ProteinModelPortaliQ9HQS0.
SMRiQ9HQS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04273. Archaea.
COG0079. LUCA.
InParanoidiQ9HQS0.
KOiK00817.
OrthoDBiPOG093Z043N.
PhylomeDBiQ9HQS0.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01023. HisC_aminotrans_2. 1 hit.
InterProiView protein in InterPro
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00155. Aminotran_1_2. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01141. hisC. 1 hit.
PROSITEiView protein in PROSITE
PS00599. AA_TRANSFER_CLASS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HQS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRDLSDHV EYRAGRGIEE VARELGRDPS EFVKLSSNEN PHGPSPKATI
60 70 80 90 100
AIREAATGVH RYPKAVHADL TGALADRWDV GDDQVWVANG GDGALDYLAR
110 120 130 140 150
ATLDPGDSVL VPSPGFTYYG MSARFHHGNV AEYDVAEGAD GFEMTADAVV
160 170 180 190 200
DAYDGERVVY LTTPHNPTGA RFTLDEIVAV ADRTDEDTLV LVDEAYGEFT
210 220 230 240 250
ETPSAVTLFD GQPAGGHAPR DDIAVLRTFS KAYGLAGIRL GYAVVPDSWA
260 270 280 290 300
DAYARVQTPF AASVIACQAG VAALDDDDHV EATTDSVAWG RDYIHDELAA
310 320 330 340 350
RTYESHGNFV LANVGDAGRV AEAAKREGVL VRDCTSFGLP EHVRITIGTR
360
SETERAVAVL NEVCDT
Length:366
Mass (Da):39,269
Last modified:January 10, 2006 - v3
Checksum:iD02179C7C71704E9
GO

Sequence cautioni

The sequence AAG19443 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19443.1. Different initiation.
PIRiG84259.
RefSeqiWP_012289267.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19443; AAG19443; VNG_1033G.
GeneIDi5952798.
KEGGihal:VNG_1033G.
PATRICifig|64091.14.peg.790.

Similar proteinsi

Entry informationi

Entry nameiHIS8_HALSA
AccessioniPrimary (citable) accession number: Q9HQS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 10, 2006
Last modified: June 7, 2017
This is version 95 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families