Q9HQC2 (AROC_HALSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	VNG_1230G

Organism

Halobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)

Taxonomic identifier

64091 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Chorismate synthase HAMAP MF_00300		PRO_0000140688

Sequences

	Sequence		Length	Mass (Da)
	Q9HQC2 [UniParc]. Last modified January 11, 2001. Version 1. Checksum: 12477860C8BA5BB0	FASTA	394	42,420
	10 20 30 40 50 60 MNGNRFGRLF EVTTYGESHG PGMGVVVSGC PAGVALDERM IQDELDRRKP GQSMITTSRG 70 80 90 100 110 120 EPDEVSIQSG LQDGYTTGTP IGMTIENKDA ESGKYEPFVT APRPSHGDYT YSAKFGTRNW 130 140 150 160 170 180 GGGGRSSARE TVNWVAAGAV AKAVLAQSDH DVRVKAHVNQ IGEIEAPDVS FEDIREHSED 190 200 210 220 230 240 NEVRCADPET AERMRALIDD YQERGDSIGG SIYFEARGVP RGLGAPRFDS VPARLGQALF 250 260 270 280 290 300 AIPATTSVEF GLGRDARSVA GKQRNEDWTV ADGDEDHVVA DEGDPIPAGN DHGGLQGGIT 310 320 330 340 350 360 TGEPIYGEAS WHAPTSIPKT QATVDWETGE EKAVTVTGRH DPSLPPRAVP VVEAMLYCTI 370 380 390 LDFMLLGGRI NPDRLDGHPG QYDTDYHPSS PRNE

References

[1]

"Genome sequence of Halobacterium species NRC-1." Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S. Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed: 11016950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700922 / JCM 11081 / NRC-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004437 Genomic DNA. Translation: AAG19593.1.
PIR	E84278.
RefSeq	NP_280113.1. NC_002607.1.
3D structure databases
ProteinModelPortal	Q9HQC2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1447893.
GenomeReviews	Gene locus VNG_1230G in contig AE004437_GR.
KEGG	hal:VNG1230G.
NMPDR	fig|64091.1.peg.1132.
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
PhylomeDB	Q9HQC2.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	HSP64091:VNG1230G-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_HALSA

Accession

Primary (citable) accession number: Q9HQC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	January 11, 2001
Last modified:	December 14, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program