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Q9HQ29 (FUMC_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fumarate hydratase class II
Short name=Fumarase C
EC=4.2.1.2
Gene names
Name:fumC
Ordered Locus Names:VNG_1356G
OrganismHalobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate = fumarate + H2O. HAMAP MF_00743

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1. HAMAP MF_00743

Subunit structure

Homotetramer By similarity. HAMAP MF_00743

Subcellular location

Cytoplasm By similarity HAMAP MF_00743.

Miscellaneous

There are 2 substrate binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors By similarity. HAMAP MF_00743

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processfumarate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componenttricarboxylic acid cycle enzyme complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionfumarate hydratase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Fumarate hydratase class II HAMAP MF_00743
PRO_0000161332

Regions

Region129 – 1324B site By similarity
Region139 – 1413Substrate binding By similarity

Sites

Binding site1011Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HQ29 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 31FF468F0B4FC261

FASTA47049,597
        10         20         30         40         50         60 
MSEDYRTEQD SLGEMQVPAD AYWGAQTQRA IENFPISGIA FGRRFVRALG VVKKAAAQAN 

        70         80         90        100        110        120 
RDLGLVDDER ADAIVAAADE VIAGEHDDQF PVDVFQTGSG TSSNMNANEV IANRAAELLG 

       130        140        150        160        170        180 
EEIGDRVVHP NDHVNYGQSS NDVIPTAMHV ASLDALVNDV KPGLETLAAE LDDKADAFDG 

       190        200        210        220        230        240 
VVKTGRTHLQ DATPVRLGQE FGGYRTQVEK GIDRIEAVAP RLSELALGGT AVGTGLNTHP 

       250        260        270        280        290        300 
EFPETAAGYI SEETGVTFRE ADNHFEAQAA HDAMNEAHGA LRTVAGSLNK IANDLRLLAS 

       310        320        330        340        350        360 
GPRNGLGEIE QPENQPGSSI MPGKINPVVA EAVNQVHKQV VGNDAAIAAG AAEGQIDLNL 

       370        380        390        400        410        420 
YKPVLAHNFL QSADMLANAS AAFGEKFVAK LEANEAACEA QVERSMALAT ALNPTIGYDK 

       430        440        450        460        470 
ASEVAKAALK EGKTVTEVVV EKGYLSEAEA ADVLDPEGMT HRGILSGDDT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004437 Genomic DNA. Translation: AAG19688.1.
PIRD84290.
RefSeqNP_280208.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HQ29.
SMRQ9HQ29. Positions 5-459.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1447987.
GenomeReviewsGene locus VNG_1356G in contig AE004437_GR.
KEGGhal:VNG1356G.
NMPDRfig|64091.1.peg.1227.

Phylogenomic databases

HOGENOMHBG284369.
OMACAAQVNY.
PhylomeDBQ9HQ29.
ProtClustDBPRK00485.

Enzyme and pathway databases

BioCycHSP64091:VNG1356G-MONOMER.

Family and domain databases

HAMAPMF_00743. FumaraseC.
[Tree]
InterProIPR003031. D_crystallin.
IPR005677. Fum_hydII.
IPR018951. Fumarase_C_C.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR024083. L-Aspartase-like_N.
IPR022761. Lyase1_N.
[Graphical view]
Gene3DG3DSA:1.10.275.10. G3DSA:1.10.275.10. 1 hit.
KOK01679.
PfamPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFUMC_HALSA
AccessionPrimary (citable) accession number: Q9HQ29
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2001
Last modified: December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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