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Q9HPW5 (HISX_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:VNG_1444G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135892

Sites

Active site3211Proton acceptor By similarity
Active site3221Proton acceptor By similarity
Metal binding2521Zinc By similarity
Metal binding2551Zinc By similarity
Metal binding3551Zinc By similarity
Metal binding4141Zinc By similarity
Binding site1241NAD By similarity
Binding site1841NAD By similarity
Binding site2071NAD By similarity
Binding site2301Substrate By similarity
Binding site2521Substrate By similarity
Binding site2551Substrate By similarity
Binding site3221Substrate By similarity
Binding site3551Substrate By similarity
Binding site4091Substrate By similarity
Binding site4141Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HPW5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: BC8C770AE42A007B

FASTA42544,457
        10         20         30         40         50         60 
MEYEAVADLA PDRRVALFER DAGVDAVRSD VAEILDRVES EGDVALRALA SEFDDVEVGN 

        70         80         90        100        110        120 
LDVTDEMERA ADAVPDDVYD AIEDAAANIR AFHEAQLPDD WRESFAAGRE LGRRFRPVRR 

       130        140        150        160        170        180 
VGVYAPGGTA AYPSSVLMGV IPAVVAGVEQ VAVATPPAET INPVTLAAAH AAGADRVYQV 

       190        200        210        220        230        240 
GGAQAIGAFA YGTETVDTVQ TVVGPGNKWV TAAKAEVRGD VEIDFLAGPS ELLVVADETA 

       250        260        270        280        290        300 
EPAFVAADLL AQAEHDPNAS VVAVTDDEAT AAAITDAVAA RLDDRERADT IRAALDNEAS 

       310        320        330        340        350        360 
GVFVARSMSE AVMFAEEYAA EHLSIQASDD EALLDRIDSA GSVFLGGYAP VAAGDYAAGT 

       370        380        390        400        410        420 
NHVLPTNGTA RVTGGLSVDT FLRSTTVQRL DREGLAALRE TVTTLADAEG LEGHAASVDA 


RFEDE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG19752.1.
PIRD84298.
RefSeqNP_280272.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HPW5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG1444G.

Proteomic databases

PaxDbQ9HPW5.
PRIDEQ9HPW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG19752; AAG19752; VNG_1444G.
GeneID1448051.
KEGGhal:VNG1444G.

Phylogenomic databases

eggNOGCOG0141.
KOK00013.
OMANAMSILL.
PhylomeDBQ9HPW5.

Enzyme and pathway databases

UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_HALSA
AccessionPrimary (citable) accession number: Q9HPW5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways