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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathway: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241NADUniRule annotation
Binding sitei184 – 1841NADUniRule annotation
Binding sitei207 – 2071NADUniRule annotation
Binding sitei230 – 2301SubstrateUniRule annotation
Metal bindingi252 – 2521ZincUniRule annotation
Binding sitei252 – 2521SubstrateUniRule annotation
Metal bindingi255 – 2551ZincUniRule annotation
Binding sitei255 – 2551SubstrateUniRule annotation
Active sitei321 – 3211Proton acceptorUniRule annotation
Active sitei322 – 3221Proton acceptorUniRule annotation
Binding sitei322 – 3221SubstrateUniRule annotation
Metal bindingi355 – 3551ZincUniRule annotation
Binding sitei355 – 3551SubstrateUniRule annotation
Binding sitei409 – 4091SubstrateUniRule annotation
Metal bindingi414 – 4141ZincUniRule annotation
Binding sitei414 – 4141SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:VNG_1444G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Histidinol dehydrogenasePRO_0000135892Add
BLAST

Proteomic databases

PaxDbiQ9HPW5.
PRIDEiQ9HPW5.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1444G.

Structurei

3D structure databases

ProteinModelPortaliQ9HPW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
InParanoidiQ9HPW5.
KOiK00013.
OMAiLSVQSFL.
PhylomeDBiQ9HPW5.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HPW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYEAVADLA PDRRVALFER DAGVDAVRSD VAEILDRVES EGDVALRALA
60 70 80 90 100
SEFDDVEVGN LDVTDEMERA ADAVPDDVYD AIEDAAANIR AFHEAQLPDD
110 120 130 140 150
WRESFAAGRE LGRRFRPVRR VGVYAPGGTA AYPSSVLMGV IPAVVAGVEQ
160 170 180 190 200
VAVATPPAET INPVTLAAAH AAGADRVYQV GGAQAIGAFA YGTETVDTVQ
210 220 230 240 250
TVVGPGNKWV TAAKAEVRGD VEIDFLAGPS ELLVVADETA EPAFVAADLL
260 270 280 290 300
AQAEHDPNAS VVAVTDDEAT AAAITDAVAA RLDDRERADT IRAALDNEAS
310 320 330 340 350
GVFVARSMSE AVMFAEEYAA EHLSIQASDD EALLDRIDSA GSVFLGGYAP
360 370 380 390 400
VAAGDYAAGT NHVLPTNGTA RVTGGLSVDT FLRSTTVQRL DREGLAALRE
410 420
TVTTLADAEG LEGHAASVDA RFEDE
Length:425
Mass (Da):44,457
Last modified:March 1, 2001 - v1
Checksum:iBC8C770AE42A007B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19752.1.
PIRiD84298.
RefSeqiNP_280272.1. NC_002607.1.
WP_010903049.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19752; AAG19752; VNG_1444G.
GeneIDi1448051.
KEGGihal:VNG1444G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19752.1.
PIRiD84298.
RefSeqiNP_280272.1. NC_002607.1.
WP_010903049.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HPW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG1444G.

Proteomic databases

PaxDbiQ9HPW5.
PRIDEiQ9HPW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG19752; AAG19752; VNG_1444G.
GeneIDi1448051.
KEGGihal:VNG1444G.

Phylogenomic databases

eggNOGiCOG0141.
InParanoidiQ9HPW5.
KOiK00013.
OMAiLSVQSFL.
PhylomeDBiQ9HPW5.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiHISX_HALSA
AccessioniPrimary (citable) accession number: Q9HPW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2001
Last modified: May 27, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.