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Q9HPW5

- HISX_HALSA

UniProt

Q9HPW5 - HISX_HALSA

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Protein
Histidinol dehydrogenase
Gene
hisD, VNG_1444G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241NAD By similarity
Binding sitei184 – 1841NAD By similarity
Binding sitei207 – 2071NAD By similarity
Binding sitei230 – 2301Substrate By similarity
Metal bindingi252 – 2521Zinc By similarity
Binding sitei252 – 2521Substrate By similarity
Metal bindingi255 – 2551Zinc By similarity
Binding sitei255 – 2551Substrate By similarity
Active sitei321 – 3211Proton acceptor By similarity
Active sitei322 – 3221Proton acceptor By similarity
Binding sitei322 – 3221Substrate By similarity
Metal bindingi355 – 3551Zinc By similarity
Binding sitei355 – 3551Substrate By similarity
Binding sitei409 – 4091Substrate By similarity
Metal bindingi414 – 4141Zinc By similarity
Binding sitei414 – 4141Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:VNG_1444G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Histidinol dehydrogenaseUniRule annotation
PRO_0000135892Add
BLAST

Proteomic databases

PaxDbiQ9HPW5.
PRIDEiQ9HPW5.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1444G.

Structurei

3D structure databases

ProteinModelPortaliQ9HPW5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiNAMSILL.
PhylomeDBiQ9HPW5.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HPW5-1 [UniParc]FASTAAdd to Basket

« Hide

MEYEAVADLA PDRRVALFER DAGVDAVRSD VAEILDRVES EGDVALRALA    50
SEFDDVEVGN LDVTDEMERA ADAVPDDVYD AIEDAAANIR AFHEAQLPDD 100
WRESFAAGRE LGRRFRPVRR VGVYAPGGTA AYPSSVLMGV IPAVVAGVEQ 150
VAVATPPAET INPVTLAAAH AAGADRVYQV GGAQAIGAFA YGTETVDTVQ 200
TVVGPGNKWV TAAKAEVRGD VEIDFLAGPS ELLVVADETA EPAFVAADLL 250
AQAEHDPNAS VVAVTDDEAT AAAITDAVAA RLDDRERADT IRAALDNEAS 300
GVFVARSMSE AVMFAEEYAA EHLSIQASDD EALLDRIDSA GSVFLGGYAP 350
VAAGDYAAGT NHVLPTNGTA RVTGGLSVDT FLRSTTVQRL DREGLAALRE 400
TVTTLADAEG LEGHAASVDA RFEDE 425
Length:425
Mass (Da):44,457
Last modified:March 1, 2001 - v1
Checksum:iBC8C770AE42A007B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG19752.1.
PIRiD84298.
RefSeqiNP_280272.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19752; AAG19752; VNG_1444G.
GeneIDi1448051.
KEGGihal:VNG1444G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG19752.1 .
PIRi D84298.
RefSeqi NP_280272.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HPW5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG1444G.

Proteomic databases

PaxDbi Q9HPW5.
PRIDEi Q9HPW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG19752 ; AAG19752 ; VNG_1444G .
GeneIDi 1448051.
KEGGi hal:VNG1444G.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi NAMSILL.
PhylomeDBi Q9HPW5.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiHISX_HALSA
AccessioniPrimary (citable) accession number: Q9HPW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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