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Q9HPW5

- HISX_HALSA

UniProt

Q9HPW5 - HISX_HALSA

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei124 – 1241NADUniRule annotation
    Binding sitei184 – 1841NADUniRule annotation
    Binding sitei207 – 2071NADUniRule annotation
    Binding sitei230 – 2301SubstrateUniRule annotation
    Metal bindingi252 – 2521ZincUniRule annotation
    Binding sitei252 – 2521SubstrateUniRule annotation
    Metal bindingi255 – 2551ZincUniRule annotation
    Binding sitei255 – 2551SubstrateUniRule annotation
    Active sitei321 – 3211Proton acceptorUniRule annotation
    Active sitei322 – 3221Proton acceptorUniRule annotation
    Binding sitei322 – 3221SubstrateUniRule annotation
    Metal bindingi355 – 3551ZincUniRule annotation
    Binding sitei355 – 3551SubstrateUniRule annotation
    Binding sitei409 – 4091SubstrateUniRule annotation
    Metal bindingi414 – 4141ZincUniRule annotation
    Binding sitei414 – 4141SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:VNG_1444G
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Histidinol dehydrogenasePRO_0000135892Add
    BLAST

    Proteomic databases

    PaxDbiQ9HPW5.
    PRIDEiQ9HPW5.

    Interactioni

    Protein-protein interaction databases

    STRINGi64091.VNG1444G.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HPW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    KOiK00013.
    OMAiNAMSILL.
    PhylomeDBiQ9HPW5.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HPW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYEAVADLA PDRRVALFER DAGVDAVRSD VAEILDRVES EGDVALRALA    50
    SEFDDVEVGN LDVTDEMERA ADAVPDDVYD AIEDAAANIR AFHEAQLPDD 100
    WRESFAAGRE LGRRFRPVRR VGVYAPGGTA AYPSSVLMGV IPAVVAGVEQ 150
    VAVATPPAET INPVTLAAAH AAGADRVYQV GGAQAIGAFA YGTETVDTVQ 200
    TVVGPGNKWV TAAKAEVRGD VEIDFLAGPS ELLVVADETA EPAFVAADLL 250
    AQAEHDPNAS VVAVTDDEAT AAAITDAVAA RLDDRERADT IRAALDNEAS 300
    GVFVARSMSE AVMFAEEYAA EHLSIQASDD EALLDRIDSA GSVFLGGYAP 350
    VAAGDYAAGT NHVLPTNGTA RVTGGLSVDT FLRSTTVQRL DREGLAALRE 400
    TVTTLADAEG LEGHAASVDA RFEDE 425
    Length:425
    Mass (Da):44,457
    Last modified:March 1, 2001 - v1
    Checksum:iBC8C770AE42A007B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG19752.1.
    PIRiD84298.
    RefSeqiNP_280272.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG19752; AAG19752; VNG_1444G.
    GeneIDi1448051.
    KEGGihal:VNG1444G.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG19752.1 .
    PIRi D84298.
    RefSeqi NP_280272.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali Q9HPW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG1444G.

    Proteomic databases

    PaxDbi Q9HPW5.
    PRIDEi Q9HPW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG19752 ; AAG19752 ; VNG_1444G .
    GeneIDi 1448051.
    KEGGi hal:VNG1444G.

    Phylogenomic databases

    eggNOGi COG0141.
    KOi K00013.
    OMAi NAMSILL.
    PhylomeDBi Q9HPW5.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.

    Entry informationi

    Entry nameiHISX_HALSA
    AccessioniPrimary (citable) accession number: Q9HPW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3