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Protein

Heme-based aerotactic transducer HemAT

Gene

hemAT

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Heme-containing signal transducer responsible for aerotaxis, the migratory response toward or away from oxygen.1 Publication

GO - Molecular functioni

  1. heme binding Source: UniProtKB
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. aerotaxis Source: UniProtKB
  2. oxygen transport Source: InterPro
  3. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-based aerotactic transducer HemAT
Gene namesi
Name:hemAT
Synonyms:htb, htr10
Ordered Locus Names:VNG_1505G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Heme-based aerotactic transducer HemATPRO_0000110568Add
BLAST

Proteomic databases

PaxDbiQ9HPR6.

Interactioni

Subunit structurei

Homotetramer.Curated

Protein-protein interaction databases

STRINGi64091.VNG1505G.

Structurei

3D structure databases

ProteinModelPortaliQ9HPR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini218 – 454237Methyl-accepting transducerPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0840.
InParanoidiQ9HPR6.
KOiK06595.
OMAiEFATTQQ.
PhylomeDBiQ9HPR6.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00283. MA. 1 hit.
[Graphical view]
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HPR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNDNDTLVT ADVRNGIDGH ALADRIGLDE AEIAWRLSFT GIDDDTMAAL
60 70 80 90 100
AAEQPLFEAT ADALVTDFYD HLESYERTQD LFANSTKTVE QLKETQAEYL
110 120 130 140 150
LGLGRGEYDT EYAAQRARIG KIHDVLGLGP DVYLGAYTRY YTGLLDALAD
160 170 180 190 200
DVVADRGEEA AAAVDELVAR FLPMLKLLTF DQQIAMDTYI DSYAQRLHDE
210 220 230 240 250
IDSRQELANA VASDVEAPLS SLEATSQDVA ERTDTMRAAT DDQVDRMADV
260 270 280 290 300
SREISSVSAS VEEVASTADD VRRTSEDAEA LAQQGEAAAD DALATMTDID
310 320 330 340 350
EATDGVTAGV EQLRERAADV ESVTGVIDDI AEQTNMLALN ASIEAARAGE
360 370 380 390 400
AGEGFAVVAD EVKALAEESR EQSTRVEELV EQMQAETEET VDQLDEVNQR
410 420 430 440 450
IGEGVERVEE AMETLQEITD AVEDAASGMQ EVSTATDEQA VSTEEVAEMV
460 470 480
DDVDDRAGEI AAALDDIADA TDQQVRTVEE VRETVGKLS
Length:489
Mass (Da):52,852
Last modified:March 1, 2001 - v1
Checksum:i8C0AEF179667791E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti213 – 2142SD → TH in AAB17881 (PubMed:8643458).Curated
Sequence conflicti239 – 2391A → R in AAB17881 (PubMed:8643458).Curated
Sequence conflicti314 – 3141R → G in AAB17881 (PubMed:8643458).Curated
Sequence conflicti452 – 4521D → G in AAB17881 (PubMed:8643458).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75436 Genomic DNA. Translation: AAB17881.1.
AE004437 Genomic DNA. Translation: AAG19801.1.
PIRiE84304.
T44978.
RefSeqiNP_280321.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19801; AAG19801; VNG_1505G.
GeneIDi1448101.
KEGGihal:VNG1505G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75436 Genomic DNA. Translation: AAB17881.1.
AE004437 Genomic DNA. Translation: AAG19801.1.
PIRiE84304.
T44978.
RefSeqiNP_280321.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HPR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG1505G.

Proteomic databases

PaxDbiQ9HPR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG19801; AAG19801; VNG_1505G.
GeneIDi1448101.
KEGGihal:VNG1505G.

Phylogenomic databases

eggNOGiCOG0840.
InParanoidiQ9HPR6.
KOiK06595.
OMAiEFATTQQ.
PhylomeDBiQ9HPR6.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00283. MA. 1 hit.
[Graphical view]
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Signal transduction in the archaeon Halobacterium salinarium is processed through three subfamilies of 13 soluble and membrane-bound transducer proteins."
    Zhang W., Brooun A., McCandless J., Banda P., Alam M.
    Proc. Natl. Acad. Sci. U.S.A. 93:4649-4654(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Flx15.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.
  3. "Myoglobin-like aerotaxis transducers in Archaea and Bacteria."
    Hou S., Larsen R.W., Boudko D., Riley C.W., Karatan E., Zimmer M., Ordal G.W., Alam M.
    Nature 403:540-544(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHMAT_HALSA
AccessioniPrimary (citable) accession number: Q9HPR6
Secondary accession number(s): P71413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2001
Last modified: April 1, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.