Q9HPR6 (HMAT_HALSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heme-based aerotactic transducer HemAT

Gene names

Name:	hemAT
Synonyms:	htb, htr10
Ordered Locus Names:	VNG_1505G

Organism

Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]

Taxonomic identifier

64091 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium › Halobacterium salinarum

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Heme-containing signal transducer responsible for aerotaxis, the migratory response toward or away from oxygen. Ref.3
Subunit structure	Homotetramer Probable.
Sequence similarities	Contains 1 methyl-accepting transducer domain.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerotaxis Inferred from direct assay Ref.3. Source: UniProtKB oxygen transport Inferred from electronic annotation. Source: InterPro
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	heme binding Inferred from direct assay Ref.3. Source: UniProtKB iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from direct assay Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Heme-based aerotactic transducer HemAT		PRO_0000110568
Regions
	Domain	218 – 454	237	Methyl-accepting transducer
Experimental info
	Sequence conflict	213 – 214	2	SD → TH in AAB17881. Ref.1
	Sequence conflict	239	1	A → R in AAB17881. Ref.1
	Sequence conflict	314	1	R → G in AAB17881. Ref.1
	Sequence conflict	452	1	D → G in AAB17881. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9HPR6 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 8C0AEF179667791E	FASTA	489	52,852
	10 20 30 40 50 60 MSNDNDTLVT ADVRNGIDGH ALADRIGLDE AEIAWRLSFT GIDDDTMAAL AAEQPLFEAT 70 80 90 100 110 120 ADALVTDFYD HLESYERTQD LFANSTKTVE QLKETQAEYL LGLGRGEYDT EYAAQRARIG 130 140 150 160 170 180 KIHDVLGLGP DVYLGAYTRY YTGLLDALAD DVVADRGEEA AAAVDELVAR FLPMLKLLTF 190 200 210 220 230 240 DQQIAMDTYI DSYAQRLHDE IDSRQELANA VASDVEAPLS SLEATSQDVA ERTDTMRAAT 250 260 270 280 290 300 DDQVDRMADV SREISSVSAS VEEVASTADD VRRTSEDAEA LAQQGEAAAD DALATMTDID 310 320 330 340 350 360 EATDGVTAGV EQLRERAADV ESVTGVIDDI AEQTNMLALN ASIEAARAGE AGEGFAVVAD 370 380 390 400 410 420 EVKALAEESR EQSTRVEELV EQMQAETEET VDQLDEVNQR IGEGVERVEE AMETLQEITD 430 440 450 460 470 480 AVEDAASGMQ EVSTATDEQA VSTEEVAEMV DDVDDRAGEI AAALDDIADA TDQQVRTVEE VRETVGKLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Signal transduction in the archaeon Halobacterium salinarium is processed through three subfamilies of 13 soluble and membrane-bound transducer proteins." Zhang W., Brooun A., McCandless J., Banda P., Alam M. Proc. Natl. Acad. Sci. U.S.A. 93:4649-4654(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Flx15.
[2]	"Genome sequence of Halobacterium species NRC-1." Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S. Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700922 / JCM 11081 / NRC-1.
[3]	"Myoglobin-like aerotaxis transducers in Archaea and Bacteria." Hou S., Larsen R.W., Boudko D., Riley C.W., Karatan E., Zimmer M., Ordal G.W., Alam M. Nature 403:540-544(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U75436 Genomic DNA. Translation: AAB17881.1. AE004437 Genomic DNA. Translation: AAG19801.1.
PIR	E84304. T44978.
RefSeq	NP_280321.1. NC_002607.1.
3D structure databases
ProteinModelPortal	Q9HPR6.
ModBase	Search...
Protein-protein interaction databases
STRING	64091.VNG1505G.
Proteomic databases
PaxDb	Q9HPR6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAG19801; AAG19801; VNG_1505G.
GeneID	1448101.
KEGG	hal:VNG1505G.
Phylogenomic databases
eggNOG	COG0840.
KO	K06595.
OMA	EFATTQQ.
ProtClustDB	CLSK296127.
Family and domain databases
Gene3D	1.10.490.10. 1 hit.
InterPro	IPR004090. Chemotax_Me-accpt_rcpt. IPR009050. Globin-like. IPR012292. Globin_dom. IPR004089. MCPsignal_dom. [Graphical view]
Pfam	PF00015. MCPsignal. 1 hit. [Graphical view]
PRINTS	PR00260. CHEMTRNSDUCR.
SMART	SM00283. MA. 1 hit. [Graphical view]
SUPFAM	SSF46458. Globin_like. 1 hit.
PROSITE	PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HMAT_HALSA

Accession

Primary (citable) accession number: Q9HPR6
Secondary accession number(s): P71413

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program