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Q9HPQ9 (KITH_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:VNG_1515G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 195195Thymidine kinase HAMAP-Rule MF_00124
PRO_0000175054

Regions

Nucleotide binding15 – 228ATP By similarity
Nucleotide binding91 – 944ATP By similarity

Sites

Active site921Proton acceptor Potential
Metal binding1481Zinc By similarity
Metal binding1511Zinc By similarity
Metal binding1861Zinc By similarity
Metal binding1891Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HPQ9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: EBA3E45144CD3B1E

FASTA19521,305
        10         20         30         40         50         60 
MHAITNSGWV EVITGSMFSG KTEELLRRLR RAEIAGQDVA AVTPAVDDRY GEATLGSHAG 

        70         80         90        100        110        120 
RSWAATVVEP TAEGVASIPT LLNGEQVVAI DEANFFPAEL VDVCQELAAD GRRVVLSGTD 

       130        140        150        160        170        180 
QTFRGEPFEP VPQLMAIAEY VDKMRAICMQ CGEPATRNQR LIEGEPAHYD DPTVMVGAEE 

       190 
TYEARCRNCH VVRRE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG19808.1.
PIRD84305.
RefSeqNP_280328.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HPQ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG1515G.

Proteomic databases

PaxDbQ9HPQ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG19808; AAG19808; VNG_1515G.
GeneID1448108.
KEGGhal:VNG1515G.

Phylogenomic databases

eggNOGCOG1435.
KOK00857.
OMACEELAND.
PhylomeDBQ9HPQ9.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_HALSA
AccessionPrimary (citable) accession number: Q9HPQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families