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Q9HPK0

- GCSPB_HALSA

UniProt

Q9HPK0 - GCSPB_HALSA

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Synonyms:gcvP2
    Ordered Locus Names:VNG_1601G
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167026Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei270 – 2701N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PaxDbiQ9HPK0.
    PRIDEiQ9HPK0.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi64091.VNG1601G.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HPK0.
    SMRiQ9HPK0. Positions 30-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    KOiK00283.
    OMAiLGETPWD.
    PhylomeDBiQ9HPK0.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HPK0-1 [UniParc]FASTAAdd to Basket

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    MEHYEQARYA PAEGETNEPL LSENDQTTVS VDPSLPDDLT RDTVELPSLE    50
    EPELARHYVR LSQQNYGVDS GPYPLGSCTM KYNPRFTEDA AALPAAAVHP 100
    DRSETALQGT LAVMHDLQDY LGRIGGMDAV TLQPPAGAAG EFTGILIAEA 150
    YHEATDGGHR NEVIVPDAAH GTNFASAALG GYDVIELPSG DDGRVDLDAL 200
    EAALGENTAA LMLTNPNTLG LFERDIEPIA EMVHDAGGLL YYDGANLNAL 250
    LGRARPGDMG FDIMHFNVHK TFATPHGGGG PGAGPVGVTD ELAGFLPDPH 300
    VRQSAGGDYE LYTPPRSIGK VHGFQGNWPV LVKAFAYIDR LGDSGLADAS 350
    AKAVLNANYL ADQLDYEIPL GPFHHEFVAS AGDQDAADVA KRMLDYGVHP 400
    PTTKWPELVA EALMTEPTET ESKRTLDDLA DAFNAVAGDD DAALADAPSR 450
    TTARRIDQTA AARNPRLSWH DLD 473
    Length:473
    Mass (Da):50,487
    Last modified:March 1, 2001 - v1
    Checksum:i665C7A7C655E22A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG19867.1.
    PIRiG84312.
    RefSeqiNP_280387.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG19867; AAG19867; VNG_1601G.
    GeneIDi1448165.
    KEGGihal:VNG1601G.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG19867.1 .
    PIRi G84312.
    RefSeqi NP_280387.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali Q9HPK0.
    SMRi Q9HPK0. Positions 30-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG1601G.

    Proteomic databases

    PaxDbi Q9HPK0.
    PRIDEi Q9HPK0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG19867 ; AAG19867 ; VNG_1601G .
    GeneIDi 1448165.
    KEGGi hal:VNG1601G.

    Phylogenomic databases

    eggNOGi COG1003.
    KOi K00283.
    OMAi LGETPWD.
    PhylomeDBi Q9HPK0.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.

    Entry informationi

    Entry nameiGCSPB_HALSA
    AccessioniPrimary (citable) accession number: Q9HPK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3