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Q9HPK0 (GCSPB_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene names
Name:gcvPB
Synonyms:gcvP2
Ordered Locus Names:VNG_1601G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713
PRO_0000167026

Amino acid modifications

Modified residue2701N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HPK0 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 665C7A7C655E22A7

FASTA47350,487
        10         20         30         40         50         60 
MEHYEQARYA PAEGETNEPL LSENDQTTVS VDPSLPDDLT RDTVELPSLE EPELARHYVR 

        70         80         90        100        110        120 
LSQQNYGVDS GPYPLGSCTM KYNPRFTEDA AALPAAAVHP DRSETALQGT LAVMHDLQDY 

       130        140        150        160        170        180 
LGRIGGMDAV TLQPPAGAAG EFTGILIAEA YHEATDGGHR NEVIVPDAAH GTNFASAALG 

       190        200        210        220        230        240 
GYDVIELPSG DDGRVDLDAL EAALGENTAA LMLTNPNTLG LFERDIEPIA EMVHDAGGLL 

       250        260        270        280        290        300 
YYDGANLNAL LGRARPGDMG FDIMHFNVHK TFATPHGGGG PGAGPVGVTD ELAGFLPDPH 

       310        320        330        340        350        360 
VRQSAGGDYE LYTPPRSIGK VHGFQGNWPV LVKAFAYIDR LGDSGLADAS AKAVLNANYL 

       370        380        390        400        410        420 
ADQLDYEIPL GPFHHEFVAS AGDQDAADVA KRMLDYGVHP PTTKWPELVA EALMTEPTET 

       430        440        450        460        470 
ESKRTLDDLA DAFNAVAGDD DAALADAPSR TTARRIDQTA AARNPRLSWH DLD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG19867.1.
PIRG84312.
RefSeqNP_280387.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HPK0.
SMRQ9HPK0. Positions 30-471.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG1601G.

Proteomic databases

PaxDbQ9HPK0.
PRIDEQ9HPK0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG19867; AAG19867; VNG_1601G.
GeneID1448165.
KEGGhal:VNG1601G.

Phylogenomic databases

eggNOGCOG1003.
KOK00283.
OMALGETPWD.
PhylomeDBQ9HPK0.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00713. GcvPB.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_HALSA
AccessionPrimary (citable) accession number: Q9HPK0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families