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Q9HPK0

- GCSPB_HALSA

UniProt

Q9HPK0 - GCSPB_HALSA

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, gcvP2, VNG_1601G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Synonyms:gcvP2
Ordered Locus Names:VNG_1601G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_0000167026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PaxDbiQ9HPK0.
PRIDEiQ9HPK0.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi64091.VNG1601G.

Structurei

3D structure databases

ProteinModelPortaliQ9HPK0.
SMRiQ9HPK0. Positions 30-471.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
KOiK00283.
OMAiLGETPWD.
PhylomeDBiQ9HPK0.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HPK0-1 [UniParc]FASTAAdd to Basket

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MEHYEQARYA PAEGETNEPL LSENDQTTVS VDPSLPDDLT RDTVELPSLE    50
EPELARHYVR LSQQNYGVDS GPYPLGSCTM KYNPRFTEDA AALPAAAVHP 100
DRSETALQGT LAVMHDLQDY LGRIGGMDAV TLQPPAGAAG EFTGILIAEA 150
YHEATDGGHR NEVIVPDAAH GTNFASAALG GYDVIELPSG DDGRVDLDAL 200
EAALGENTAA LMLTNPNTLG LFERDIEPIA EMVHDAGGLL YYDGANLNAL 250
LGRARPGDMG FDIMHFNVHK TFATPHGGGG PGAGPVGVTD ELAGFLPDPH 300
VRQSAGGDYE LYTPPRSIGK VHGFQGNWPV LVKAFAYIDR LGDSGLADAS 350
AKAVLNANYL ADQLDYEIPL GPFHHEFVAS AGDQDAADVA KRMLDYGVHP 400
PTTKWPELVA EALMTEPTET ESKRTLDDLA DAFNAVAGDD DAALADAPSR 450
TTARRIDQTA AARNPRLSWH DLD 473
Length:473
Mass (Da):50,487
Last modified:March 1, 2001 - v1
Checksum:i665C7A7C655E22A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG19867.1.
PIRiG84312.
RefSeqiNP_280387.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19867; AAG19867; VNG_1601G.
GeneIDi1448165.
KEGGihal:VNG1601G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG19867.1 .
PIRi G84312.
RefSeqi NP_280387.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HPK0.
SMRi Q9HPK0. Positions 30-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG1601G.

Proteomic databases

PaxDbi Q9HPK0.
PRIDEi Q9HPK0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG19867 ; AAG19867 ; VNG_1601G .
GeneIDi 1448165.
KEGGi hal:VNG1601G.

Phylogenomic databases

eggNOGi COG1003.
KOi K00283.
OMAi LGETPWD.
PhylomeDBi Q9HPK0.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiGCSPB_HALSA
AccessioniPrimary (citable) accession number: Q9HPK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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