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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Synonyms:gcvP2
Ordered Locus Names:VNG_1601G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001670261 – 473Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ9HPK0

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi64091.VNG1601G

Structurei

3D structure databases

ProteinModelPortaliQ9HPK0
SMRiQ9HPK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00076 Archaea
COG1003 LUCA
InParanoidiQ9HPK0
KOiK00283
OMAiMHINLHK
OrthoDBiPOG093Z01WJ
PhylomeDBiQ9HPK0

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HPK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHYEQARYA PAEGETNEPL LSENDQTTVS VDPSLPDDLT RDTVELPSLE
60 70 80 90 100
EPELARHYVR LSQQNYGVDS GPYPLGSCTM KYNPRFTEDA AALPAAAVHP
110 120 130 140 150
DRSETALQGT LAVMHDLQDY LGRIGGMDAV TLQPPAGAAG EFTGILIAEA
160 170 180 190 200
YHEATDGGHR NEVIVPDAAH GTNFASAALG GYDVIELPSG DDGRVDLDAL
210 220 230 240 250
EAALGENTAA LMLTNPNTLG LFERDIEPIA EMVHDAGGLL YYDGANLNAL
260 270 280 290 300
LGRARPGDMG FDIMHFNVHK TFATPHGGGG PGAGPVGVTD ELAGFLPDPH
310 320 330 340 350
VRQSAGGDYE LYTPPRSIGK VHGFQGNWPV LVKAFAYIDR LGDSGLADAS
360 370 380 390 400
AKAVLNANYL ADQLDYEIPL GPFHHEFVAS AGDQDAADVA KRMLDYGVHP
410 420 430 440 450
PTTKWPELVA EALMTEPTET ESKRTLDDLA DAFNAVAGDD DAALADAPSR
460 470
TTARRIDQTA AARNPRLSWH DLD
Length:473
Mass (Da):50,487
Last modified:March 1, 2001 - v1
Checksum:i665C7A7C655E22A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG19867.1
PIRiG84312
RefSeqiWP_010903165.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG19867; AAG19867; VNG_1601G
GeneIDi5954342
KEGGihal:VNG_1601G
PATRICifig|64091.14.peg.1220

Similar proteinsi

Entry informationi

Entry nameiGCSPB_HALSA
AccessioniPrimary (citable) accession number: Q9HPK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health