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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Synonyms:gcvP2
Ordered Locus Names:VNG_1601G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PaxDbiQ9HPK0.
PRIDEiQ9HPK0.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi64091.VNG1601G.

Structurei

3D structure databases

ProteinModelPortaliQ9HPK0.
SMRiQ9HPK0. Positions 30-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
InParanoidiQ9HPK0.
KOiK00283.
OMAiMHINLHK.
PhylomeDBiQ9HPK0.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR000192. Aminotrans_V_dom.
IPR023012. GcvPB.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HPK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHYEQARYA PAEGETNEPL LSENDQTTVS VDPSLPDDLT RDTVELPSLE
60 70 80 90 100
EPELARHYVR LSQQNYGVDS GPYPLGSCTM KYNPRFTEDA AALPAAAVHP
110 120 130 140 150
DRSETALQGT LAVMHDLQDY LGRIGGMDAV TLQPPAGAAG EFTGILIAEA
160 170 180 190 200
YHEATDGGHR NEVIVPDAAH GTNFASAALG GYDVIELPSG DDGRVDLDAL
210 220 230 240 250
EAALGENTAA LMLTNPNTLG LFERDIEPIA EMVHDAGGLL YYDGANLNAL
260 270 280 290 300
LGRARPGDMG FDIMHFNVHK TFATPHGGGG PGAGPVGVTD ELAGFLPDPH
310 320 330 340 350
VRQSAGGDYE LYTPPRSIGK VHGFQGNWPV LVKAFAYIDR LGDSGLADAS
360 370 380 390 400
AKAVLNANYL ADQLDYEIPL GPFHHEFVAS AGDQDAADVA KRMLDYGVHP
410 420 430 440 450
PTTKWPELVA EALMTEPTET ESKRTLDDLA DAFNAVAGDD DAALADAPSR
460 470
TTARRIDQTA AARNPRLSWH DLD
Length:473
Mass (Da):50,487
Last modified:March 1, 2001 - v1
Checksum:i665C7A7C655E22A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19867.1.
PIRiG84312.
RefSeqiNP_280387.1. NC_002607.1.
WP_010903165.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19867; AAG19867; VNG_1601G.
GeneIDi1448165.
KEGGihal:VNG1601G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19867.1.
PIRiG84312.
RefSeqiNP_280387.1. NC_002607.1.
WP_010903165.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HPK0.
SMRiQ9HPK0. Positions 30-471.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG1601G.

Proteomic databases

PaxDbiQ9HPK0.
PRIDEiQ9HPK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG19867; AAG19867; VNG_1601G.
GeneIDi1448165.
KEGGihal:VNG1601G.

Phylogenomic databases

eggNOGiCOG1003.
InParanoidiQ9HPK0.
KOiK00283.
OMAiMHINLHK.
PhylomeDBiQ9HPK0.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR000192. Aminotrans_V_dom.
IPR023012. GcvPB.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiGCSPB_HALSA
AccessioniPrimary (citable) accession number: Q9HPK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2001
Last modified: May 27, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.