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Q9HPJ9

- GCSPA_HALSA

UniProt

Q9HPJ9 - GCSPA_HALSA

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, gcvP1, VNG_1603G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Synonyms:gcvP1
Ordered Locus Names:VNG_1603G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_0000166983Add
BLAST

Proteomic databases

PaxDbiQ9HPJ9.
PRIDEiQ9HPJ9.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi64091.VNG1603G.

Structurei

3D structure databases

ProteinModelPortaliQ9HPJ9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
KOiK00282.
OMAiGLEVANC.
PhylomeDBiQ9HPJ9.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HPJ9-1 [UniParc]FASTAAdd to Basket

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MSGSPYASPS EADTDAMLDA VGVDRVDELF DIPPEVSFDG EFGIDAKSEQ    50
AALRGVRRRL SDNDDLTEFL GRGHYEHYVP SLVDSVSQRS EFITSYTQYQ 100
PEITQGFLQV LFEYQSLLVE LTGLGVANCS MYDAATALAE AALLAKRVRA 150
ADGNRVLVPG FVRDSHVDVL RNYTSGSDVV VERYATDAGN VDLDALEAAM 200
DADVVMVYAE NPTTCGTVEE QLCAVGDLAD SHDALFCLGS DPVAMSILQR 250
PVDVGADVVV GDASVLGMPT SYGTGLGVFA TRKEFLRQVP GRLVGASEDD 300
AGTRAFTLTL QTREQHIRKE RATSNICTNQ AWVALRAAIH AAWLGADGLV 350
DLAERMVELP RDLAARLDDV SGVTAPVHDD RHHIREFQAR TEQPAPAVAS 400
ALEAEGFGVH AVDDHTIQVC VTDANEHATD AFVAAVREVS E 441
Length:441
Mass (Da):47,460
Last modified:March 1, 2001 - v1
Checksum:iC3D83F0DF88F6E4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG19868.1.
PIRiH84312.
RefSeqiNP_280388.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19868; AAG19868; VNG_1603G.
GeneIDi1448166.
KEGGihal:VNG1603G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG19868.1 .
PIRi H84312.
RefSeqi NP_280388.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HPJ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG1603G.

Proteomic databases

PaxDbi Q9HPJ9.
PRIDEi Q9HPJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG19868 ; AAG19868 ; VNG_1603G .
GeneIDi 1448166.
KEGGi hal:VNG1603G.

Phylogenomic databases

eggNOGi COG0403.
KOi K00282.
OMAi GLEVANC.
PhylomeDBi Q9HPJ9.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiGCSPA_HALSA
AccessioniPrimary (citable) accession number: Q9HPJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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