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Q9HPJ9

- GCSPA_HALSA

UniProt

Q9HPJ9 - GCSPA_HALSA

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Synonyms:gcvP1
Ordered Locus Names:VNG_1603G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_0000166983Add
BLAST

Proteomic databases

PaxDbiQ9HPJ9.
PRIDEiQ9HPJ9.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi64091.VNG1603G.

Structurei

3D structure databases

ProteinModelPortaliQ9HPJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
InParanoidiQ9HPJ9.
KOiK00282.
OMAiGLEVANC.
PhylomeDBiQ9HPJ9.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HPJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGSPYASPS EADTDAMLDA VGVDRVDELF DIPPEVSFDG EFGIDAKSEQ
60 70 80 90 100
AALRGVRRRL SDNDDLTEFL GRGHYEHYVP SLVDSVSQRS EFITSYTQYQ
110 120 130 140 150
PEITQGFLQV LFEYQSLLVE LTGLGVANCS MYDAATALAE AALLAKRVRA
160 170 180 190 200
ADGNRVLVPG FVRDSHVDVL RNYTSGSDVV VERYATDAGN VDLDALEAAM
210 220 230 240 250
DADVVMVYAE NPTTCGTVEE QLCAVGDLAD SHDALFCLGS DPVAMSILQR
260 270 280 290 300
PVDVGADVVV GDASVLGMPT SYGTGLGVFA TRKEFLRQVP GRLVGASEDD
310 320 330 340 350
AGTRAFTLTL QTREQHIRKE RATSNICTNQ AWVALRAAIH AAWLGADGLV
360 370 380 390 400
DLAERMVELP RDLAARLDDV SGVTAPVHDD RHHIREFQAR TEQPAPAVAS
410 420 430 440
ALEAEGFGVH AVDDHTIQVC VTDANEHATD AFVAAVREVS E
Length:441
Mass (Da):47,460
Last modified:March 1, 2001 - v1
Checksum:iC3D83F0DF88F6E4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19868.1.
PIRiH84312.
RefSeqiNP_280388.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19868; AAG19868; VNG_1603G.
GeneIDi1448166.
KEGGihal:VNG1603G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19868.1 .
PIRi H84312.
RefSeqi NP_280388.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HPJ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG1603G.

Proteomic databases

PaxDbi Q9HPJ9.
PRIDEi Q9HPJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG19868 ; AAG19868 ; VNG_1603G .
GeneIDi 1448166.
KEGGi hal:VNG1603G.

Phylogenomic databases

eggNOGi COG0403.
InParanoidi Q9HPJ9.
KOi K00282.
OMAi GLEVANC.
PhylomeDBi Q9HPJ9.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiGCSPA_HALSA
AccessioniPrimary (citable) accession number: Q9HPJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3