Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9HPG5 (TRPE1_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anthranilate synthase component 1 1

EC=4.1.3.27
Alternative name(s):
Anthranilate synthase component I 1
Gene names
Name:trpE1
Ordered Locus Names:VNG_1647G
OrganismHalobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Anthranilate synthase component 1 1
PRO_0000154125

Sequences

Sequence LengthMass (Da)Tools
Q9HPG5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 7B871F30685F02A3

FASTA52756,275
        10         20         30         40         50         60 
MIETDRETFT ALADDGPAIV RVAADLDIDV APLTAYDALV ADADDHAFLL ESAEKTPASD 

        70         80         90        100        110        120 
PDGAFTPDTT TEETRHARYS FVGYDPAAVV TVDPDDTTIT RLRDDPITDL LDAPDHATGD 

       130        140        150        160        170        180 
VLDRLRSVMP AVPRRNIPTE DRQLLDGGLV GFLAYDAVYD LWLDEVGVER PPTPLPDAEF 

       190        200        210        220        230        240 
AVTTRTLVFD RATDSVSLVC TPVADADTAT DVYDALEAEA KRVQAVLRDA TAPATAGIEV 

       250        260        270        280        290        300 
TTERAGDRDA YTDAVETAAT AVRDGEVYQA VVSRTRELDG DIDPRALYDA LRAVNPSPYM 

       310        320        330        340        350        360 
FLLAHGDHTV VGASPETLVA VHDDTVVTNP IAGTCQRGAS PVADRRLAGE MLADEKERAE 

       370        380        390        400        410        420 
HTMLVDLARN DVRRVSAPGT VSVPEFMRVL KYSHVQHIES TVTGTLAADA DAFDATRAAF 

       430        440        450        460        470        480 
PAGTLSGAPK VRAMEHIDAI EATPRGIYGG GVGYFSWTGD AELAITIRSG TITHTGDEDT 

       490        500        510        520 
LTVRAGAGVV ADSDPDAEYE ETEAKMDGVL AAVDRLRTTD DGEAVHR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG19902.1.
PIRB84317.
RefSeqNP_280422.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HPG5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1448201.
GenomeReviewsGene locus VNG_1647G in contig AE004437_GR.
KEGGhal:VNG1647G.
NMPDRfig|64091.1.peg.1443.

Phylogenomic databases

HOGENOMHBG507440.
OMASNPIAGT.
PhylomeDBQ9HPG5.
ProtClustDBCLSK511484.

Enzyme and pathway databases

BioCycHSP64091:VNG1647G-MONOMER.

Family and domain databases

InterProIPR005801. ADC_synthase.
IPR019999. Anth_synth_I.
IPR006805. Anth_synth_I_N.
IPR010116. Anthranilate_synth_I_arc.
IPR015890. Chorismate-bd_C.
[Graphical view]
Gene3DG3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KOK01657.
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
SUPFAMSSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMsTIGR01820. TrpE-arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE1_HALSA
AccessionPrimary (citable) accession number: Q9HPG5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2001
Last modified: December 14, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families