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Reviewed, UniProtKB/Swiss-Prot Q9HPG5 (TRPE1_HALSA)

Last modified February 9, 2010. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Anthranilate synthase component 1 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I 1
Gene names
Name: trpE1
Ordered Locus Names: VNG_1647G
OrganismHalobacterium salinarium (Halobacterium halobium) [Complete proteome] [HAMAP]
Taxonomic identifier2242 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionanthranilate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Anthranilate synthase component 1 1
PRO_0000154125

Sequences

Sequence LengthMass (Da)Tools
Q9HPG5-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 7B871F30685F02A3

FASTA52756,275
        10         20         30         40         50         60 
MIETDRETFT ALADDGPAIV RVAADLDIDV APLTAYDALV ADADDHAFLL ESAEKTPASD 

        70         80         90        100        110        120 
PDGAFTPDTT TEETRHARYS FVGYDPAAVV TVDPDDTTIT RLRDDPITDL LDAPDHATGD 

       130        140        150        160        170        180 
VLDRLRSVMP AVPRRNIPTE DRQLLDGGLV GFLAYDAVYD LWLDEVGVER PPTPLPDAEF 

       190        200        210        220        230        240 
AVTTRTLVFD RATDSVSLVC TPVADADTAT DVYDALEAEA KRVQAVLRDA TAPATAGIEV 

       250        260        270        280        290        300 
TTERAGDRDA YTDAVETAAT AVRDGEVYQA VVSRTRELDG DIDPRALYDA LRAVNPSPYM 

       310        320        330        340        350        360 
FLLAHGDHTV VGASPETLVA VHDDTVVTNP IAGTCQRGAS PVADRRLAGE MLADEKERAE 

       370        380        390        400        410        420 
HTMLVDLARN DVRRVSAPGT VSVPEFMRVL KYSHVQHIES TVTGTLAADA DAFDATRAAF 

       430        440        450        460        470        480 
PAGTLSGAPK VRAMEHIDAI EATPRGIYGG GVGYFSWTGD AELAITIRSG TITHTGDEDT 

       490        500        510        520 
LTVRAGAGVV ADSDPDAEYE ETEAKMDGVL AAVDRLRTTD DGEAVHR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG19902.1.
PIRB84317.
RefSeqNP_280422.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1448201.
GenomeReviewsGene locus VNG_1647G in contig AE004437_GR.
KEGGhal:VNG1647G.
NMPDRfig|64091.1.peg.1443.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG507440.
OMAIANAINH.

Enzyme and pathway databases

BioCycHSP64091:VNG1647G-MONOMER.
BRENDA4.1.3.27. 141893.

Family and domain databases

InterProIPR005801. ADC_synthase.
IPR006805. Anth_synth_I_N.
IPR010116. Anthranilate_synth_I_arc.
IPR019999. Anthranilate_synth_I_C.
IPR015890. Chorismate-bd_C.
[Graphical view]
Gene3DG3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHERPTHR11236. TRPE_1_chor_bd. 1 hit.
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
TIGRFAMsTIGR01820. TrpE-arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE1_HALSA
AccessionPrimary (citable) accession number: Q9HPG5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2001
Last modified: February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents