Reviewed, UniProtKB/Swiss-Prot Q9HPG5 (TRPE1_HALSA)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I 1

Gene names

Name:	trpE1
Ordered Locus Names:	VNG_1647G

Organism

Halobacterium salinarium (Halobacterium halobium) [Complete proteome] [HAMAP]

Taxonomic identifier

2242 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 527	527	Anthranilate synthase component 1 1		PRO_0000154125

Sequences

	Sequence		Length	Mass (Da)
	Q9HPG5-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 7B871F30685F02A3	FASTA	527	56,275
	10 20 30 40 50 60 MIETDRETFT ALADDGPAIV RVAADLDIDV APLTAYDALV ADADDHAFLL ESAEKTPASD 70 80 90 100 110 120 PDGAFTPDTT TEETRHARYS FVGYDPAAVV TVDPDDTTIT RLRDDPITDL LDAPDHATGD 130 140 150 160 170 180 VLDRLRSVMP AVPRRNIPTE DRQLLDGGLV GFLAYDAVYD LWLDEVGVER PPTPLPDAEF 190 200 210 220 230 240 AVTTRTLVFD RATDSVSLVC TPVADADTAT DVYDALEAEA KRVQAVLRDA TAPATAGIEV 250 260 270 280 290 300 TTERAGDRDA YTDAVETAAT AVRDGEVYQA VVSRTRELDG DIDPRALYDA LRAVNPSPYM 310 320 330 340 350 360 FLLAHGDHTV VGASPETLVA VHDDTVVTNP IAGTCQRGAS PVADRRLAGE MLADEKERAE 370 380 390 400 410 420 HTMLVDLARN DVRRVSAPGT VSVPEFMRVL KYSHVQHIES TVTGTLAADA DAFDATRAAF 430 440 450 460 470 480 PAGTLSGAPK VRAMEHIDAI EATPRGIYGG GVGYFSWTGD AELAITIRSG TITHTGDEDT 490 500 510 520 LTVRAGAGVV ADSDPDAEYE ETEAKMDGVL AAVDRLRTTD DGEAVHR

References

[1]

"Genome sequence of Halobacterium species NRC-1." Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S. Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed: 11016950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700922 / JCM 11081 / NRC-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004437 Genomic DNA. Translation: AAG19902.1.
PIR	B84317.
RefSeq	NP_280422.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1448201.
GenomeReviews	Gene locus VNG_1647G in contig AE004437_GR.
KEGG	hal:VNG1647G.
NMPDR	fig|64091.1.peg.1443.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG507440.
OMA	IANAINH.
Enzyme and pathway databases
BioCyc	HSP64091:VNG1647G-MONOMER.
BRENDA	4.1.3.27. 141893.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR010116. Anthranilate_synth_I_arc. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
TIGRFAMs	TIGR01820. TrpE-arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE1_HALSA

Accession

Primary (citable) accession number: Q9HPG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	March 1, 2001
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)