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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpF
Ordered Locus Names:VNG_1648G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154400Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1648G.

Structurei

3D structure databases

ProteinModelPortaliQ9HPG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiCOG0135.
InParanoidiQ9HPG4.
KOiK01817.
OMAiDTPREVD.
PhylomeDBiQ9HPG4.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HPG4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRVKVCGLT TERDHAAAVA AGADAVGIIA DVPVETPREV SVETATALRA
60 70 80 90 100
ATPPFVTSVL VTMPATPEHA VDLVRTVAPD AVQLHGDLPV GDAAYVAANT
110 120 130 140 150
PCPVIKAVTA GDQSAARYAD VVDALLVDSP PTDDAGAGGG TGRTHDWAAT
160 170 180 190 200
RAFADRVDTP VVLAGGLTPA NVADAVDTVD PFAVDVASGV EARPGEKDHA
210
AVSAFVARAT ATPDPTLT
Length:218
Mass (Da):21,903
Last modified:March 1, 2001 - v1
Checksum:i2F916B7E1E10B7F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19903.1.
PIRiC84317.
RefSeqiNP_280423.1. NC_002607.1.
WP_010903201.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19903; AAG19903; VNG_1648G.
GeneIDi1448202.
KEGGihal:VNG1648G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19903.1.
PIRiC84317.
RefSeqiNP_280423.1. NC_002607.1.
WP_010903201.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HPG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG1648G.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG19903; AAG19903; VNG_1648G.
GeneIDi1448202.
KEGGihal:VNG1648G.

Phylogenomic databases

eggNOGiCOG0135.
InParanoidiQ9HPG4.
KOiK01817.
OMAiDTPREVD.
PhylomeDBiQ9HPG4.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiTRPF_HALSA
AccessioniPrimary (citable) accession number: Q9HPG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.