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Protein

Transducer protein CosT

Gene

cosT

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mediates chemotaxis towards compatible osmolytes. Probably transduces the signal from the substrate-binding protein CosB to the histidine kinase CheA (By similarity).By similarity

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Transducer protein CosT
Alternative name(s):
Compatible solute transducer protein
HTP IV
Gene namesi
Name:cosT
Synonyms:htpIV, htr5
Ordered Locus Names:VNG_1760G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Topological domaini60 – 323264ExtracellularSequence AnalysisAdd
BLAST
Transmembranei324 – 34421HelicalSequence AnalysisAdd
BLAST
Topological domaini345 – 810466CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 810810Transducer protein CosTPRO_0000110551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei556 – 5561Glutamate methyl ester (Glu)By similarity
Modified residuei739 – 7391Glutamate methyl ester (Glu)By similarity

Post-translational modificationi

Methylated by CheR.By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9HP84.
PRIDEiQ9HP84.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1760G.

Structurei

3D structure databases

ProteinModelPortaliQ9HP84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini345 – 39753HAMP 1PROSITE-ProRule annotationAdd
BLAST
Domaini439 – 49355HAMP 2PROSITE-ProRule annotationAdd
BLAST
Domaini512 – 748237Methyl-accepting transducerPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 HAMP domains.PROSITE-ProRule annotation
Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0840.
InParanoidiQ9HP84.
OMAiTQSPGNP.
PhylomeDBiQ9HP84.

Family and domain databases

InterProiIPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
SMARTiSM00304. HAMP. 3 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HP84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPTADAGD NSPSSTDTAP LDRVKAIALL PLRSYLVKFA VALLVILVII
60 70 80 90 100
AAGGFWVQAD ATATLEANTE QQLEQEAVSD ATEIGDWLER NEQSVLIASN
110 120 130 140 150
NPRLGFNTTA ADKQAYVTQL VAAELDADRI ADVHVADPTV GGASDARIVA
160 170 180 190 200
STDEDARGTR VSADTHPWVD RTRSIGRDTV VSTNPYRTAG GQRVVSSMSV
210 220 230 240 250
AADLTHVLVV EYTAGDLSDQ FGAGIDGTFT QVVRPTSDAT AVLFSDAGTD
260 270 280 290 300
AVGQPYIPDR SQSEIPALDS ATEQGQFTNT PTKDSVLDRE YVAAYTTVPG
310 320 330 340 350
KNWVVVKHAP SESAFALSNQ IRTGILGFIL VALVGVVLVG GTIGRNTAAA
360 370 380 390 400
VQSLSAAAAE IEAGNYDVDV ASSRRDEIGQ LFASIGSMRD ALVTQIDEAE
410 420 430 440 450
AAREQATEAQ QDAEAERERA EDARERAEDA KADAEALAAE LEAQAERYSD
460 470 480 490 500
VMAACADGDL TRRMPADDTD NEAMAAIAAS FNEMLAQWEH TIIDIQEFAD
510 520 530 540 550
AVATASEEAE VGAADAERAS GQVSESVQEI AGAADEQRNM LDTVSGEMTD
560 570 580 590 600
LSAAIEEVAA SADSVAEHSH QTAEIARDGE QTAEDAIERS LTVQEAIDAT
610 620 630 640 650
VQNVEALDDQ MAEISEIVDL ISDIAEQTNM LALNANIEAA RADKSGDGFA
660 670 680 690 700
VVADEVKDLA EETQESAGDI ERRITEVQSQ TTATVAEARA AEESMDAGID
710 720 730 740 750
AVEEVVDAFT AVSDHADETD TGVQEISDTT DDQAASTEEA VSMTEEVADL
760 770 780 790 800
SDSTAGEAQS VSAAAEEQAA SMSEISDSVE SLSGQAEQLK ALLSEFEVDA
810
DRDVTPTQTD
Length:810
Mass (Da):85,219
Last modified:January 11, 2001 - v1
Checksum:i4BF36E4B7D22BD80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191A → G in CAA64841 (PubMed:8674984).Curated
Sequence conflicti592 – 5921T → S in CAA64841 (PubMed:8674984).Curated
Sequence conflicti735 – 7351A → S in CAA64841 (PubMed:8674984).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95589 Genomic DNA. Translation: CAA64841.1.
AE004437 Genomic DNA. Translation: AAG19986.1.
PIRiF84327.
T46810.
RefSeqiNP_280506.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19986; AAG19986; VNG_1760G.
GeneIDi1448288.
KEGGihal:VNG1760G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95589 Genomic DNA. Translation: CAA64841.1.
AE004437 Genomic DNA. Translation: AAG19986.1.
PIRiF84327.
T46810.
RefSeqiNP_280506.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HP84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG1760G.

Proteomic databases

PaxDbiQ9HP84.
PRIDEiQ9HP84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG19986; AAG19986; VNG_1760G.
GeneIDi1448288.
KEGGihal:VNG1760G.

Phylogenomic databases

eggNOGiCOG0840.
InParanoidiQ9HP84.
OMAiTQSPGNP.
PhylomeDBiQ9HP84.

Family and domain databases

InterProiIPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
SMARTiSM00304. HAMP. 3 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: R1 / S9.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiCOST_HALSA
AccessioniPrimary (citable) accession number: Q9HP84
Secondary accession number(s): Q48317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: March 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.