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Q9HP84

- COST_HALSA

UniProt

Q9HP84 - COST_HALSA

Protein

Transducer protein CosT

Gene

cosT

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (11 Jan 2001)
      Previous versions | rss
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    Functioni

    Mediates chemotaxis towards compatible osmolytes. Probably transduces the signal from the substrate-binding protein CosB to the histidine kinase CheA By similarity.By similarity

    GO - Molecular functioni

    1. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transducer

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transducer protein CosT
    Alternative name(s):
    Compatible solute transducer protein
    HTP IV
    Gene namesi
    Name:cosT
    Synonyms:htpIV, htr5
    Ordered Locus Names:VNG_1760G
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 810810Transducer protein CosTPRO_0000110551Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei556 – 5561Glutamate methyl ester (Glu)By similarity
    Modified residuei739 – 7391Glutamate methyl ester (Glu)By similarity

    Post-translational modificationi

    Methylated by CheR.By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiQ9HP84.
    PRIDEiQ9HP84.

    Interactioni

    Protein-protein interaction databases

    STRINGi64091.VNG1760G.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HP84.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini60 – 323264ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini345 – 810466CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini345 – 39753HAMP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini439 – 49355HAMP 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini512 – 748237Methyl-accepting transducerPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 HAMP domains.PROSITE-ProRule annotation
    Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0840.
    OMAiSEINDSI.
    PhylomeDBiQ9HP84.

    Family and domain databases

    InterProiIPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    [Graphical view]
    PfamiPF00672. HAMP. 1 hit.
    PF00015. MCPsignal. 1 hit.
    [Graphical view]
    SMARTiSM00304. HAMP. 3 hits.
    SM00283. MA. 1 hit.
    [Graphical view]
    PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HP84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEPTADAGD NSPSSTDTAP LDRVKAIALL PLRSYLVKFA VALLVILVII    50
    AAGGFWVQAD ATATLEANTE QQLEQEAVSD ATEIGDWLER NEQSVLIASN 100
    NPRLGFNTTA ADKQAYVTQL VAAELDADRI ADVHVADPTV GGASDARIVA 150
    STDEDARGTR VSADTHPWVD RTRSIGRDTV VSTNPYRTAG GQRVVSSMSV 200
    AADLTHVLVV EYTAGDLSDQ FGAGIDGTFT QVVRPTSDAT AVLFSDAGTD 250
    AVGQPYIPDR SQSEIPALDS ATEQGQFTNT PTKDSVLDRE YVAAYTTVPG 300
    KNWVVVKHAP SESAFALSNQ IRTGILGFIL VALVGVVLVG GTIGRNTAAA 350
    VQSLSAAAAE IEAGNYDVDV ASSRRDEIGQ LFASIGSMRD ALVTQIDEAE 400
    AAREQATEAQ QDAEAERERA EDARERAEDA KADAEALAAE LEAQAERYSD 450
    VMAACADGDL TRRMPADDTD NEAMAAIAAS FNEMLAQWEH TIIDIQEFAD 500
    AVATASEEAE VGAADAERAS GQVSESVQEI AGAADEQRNM LDTVSGEMTD 550
    LSAAIEEVAA SADSVAEHSH QTAEIARDGE QTAEDAIERS LTVQEAIDAT 600
    VQNVEALDDQ MAEISEIVDL ISDIAEQTNM LALNANIEAA RADKSGDGFA 650
    VVADEVKDLA EETQESAGDI ERRITEVQSQ TTATVAEARA AEESMDAGID 700
    AVEEVVDAFT AVSDHADETD TGVQEISDTT DDQAASTEEA VSMTEEVADL 750
    SDSTAGEAQS VSAAAEEQAA SMSEISDSVE SLSGQAEQLK ALLSEFEVDA 800
    DRDVTPTQTD 810
    Length:810
    Mass (Da):85,219
    Last modified:January 11, 2001 - v1
    Checksum:i4BF36E4B7D22BD80
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191A → G in CAA64841. (PubMed:8674984)Curated
    Sequence conflicti592 – 5921T → S in CAA64841. (PubMed:8674984)Curated
    Sequence conflicti735 – 7351A → S in CAA64841. (PubMed:8674984)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95589 Genomic DNA. Translation: CAA64841.1.
    AE004437 Genomic DNA. Translation: AAG19986.1.
    PIRiF84327.
    T46810.
    RefSeqiNP_280506.1. NC_002607.1.
    WP_010903284.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG19986; AAG19986; VNG_1760G.
    GeneIDi1448288.
    KEGGihal:VNG1760G.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95589 Genomic DNA. Translation: CAA64841.1 .
    AE004437 Genomic DNA. Translation: AAG19986.1 .
    PIRi F84327.
    T46810.
    RefSeqi NP_280506.1. NC_002607.1.
    WP_010903284.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali Q9HP84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG1760G.

    Proteomic databases

    PaxDbi Q9HP84.
    PRIDEi Q9HP84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG19986 ; AAG19986 ; VNG_1760G .
    GeneIDi 1448288.
    KEGGi hal:VNG1760G.

    Phylogenomic databases

    eggNOGi COG0840.
    OMAi SEINDSI.
    PhylomeDBi Q9HP84.

    Family and domain databases

    InterProi IPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    [Graphical view ]
    Pfami PF00672. HAMP. 1 hit.
    PF00015. MCPsignal. 1 hit.
    [Graphical view ]
    SMARTi SM00304. HAMP. 3 hits.
    SM00283. MA. 1 hit.
    [Graphical view ]
    PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: R1 / S9.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.

    Entry informationi

    Entry nameiCOST_HALSA
    AccessioniPrimary (citable) accession number: Q9HP84
    Secondary accession number(s): Q48317
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3