Q9HP84 (HTR4_HALSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Halobacterial transducer protein 4

Alternative name(s):
HTP IV

Gene names

Name:	htr5
Synonyms:	htpIV
Ordered Locus Names:	VNG_1760G

Organism

Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]

Taxonomic identifier

64091 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium › Halobacterium salinarum

Protein attributes

Sequence length	810 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Potentially involved in chemo- or phototactic signal transduction.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Contains 2 HAMP domains. Contains 1 methyl-accepting transducer domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Molecular function	Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 810	810	Halobacterial transducer protein 4		PRO_0000110551
Regions
	Topological domain	1 – 38	38	Cytoplasmic Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Topological domain	60 – 323	264	Extracellular Potential
	Transmembrane	324 – 344	21	Helical; Potential
	Topological domain	345 – 810	466	Cytoplasmic Potential
	Domain	345 – 397	53	HAMP 1
	Domain	439 – 493	55	HAMP 2
	Domain	512 – 748	237	Methyl-accepting transducer
Experimental info
	Sequence conflict	19	1	A → G in CAA64841. Ref.1
	Sequence conflict	592	1	T → S in CAA64841. Ref.1
	Sequence conflict	735	1	A → S in CAA64841. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9HP84 [UniParc]. Last modified January 11, 2001. Version 1. Checksum: 4BF36E4B7D22BD80	FASTA	810	85,219
	10 20 30 40 50 60 MSEPTADAGD NSPSSTDTAP LDRVKAIALL PLRSYLVKFA VALLVILVII AAGGFWVQAD 70 80 90 100 110 120 ATATLEANTE QQLEQEAVSD ATEIGDWLER NEQSVLIASN NPRLGFNTTA ADKQAYVTQL 130 140 150 160 170 180 VAAELDADRI ADVHVADPTV GGASDARIVA STDEDARGTR VSADTHPWVD RTRSIGRDTV 190 200 210 220 230 240 VSTNPYRTAG GQRVVSSMSV AADLTHVLVV EYTAGDLSDQ FGAGIDGTFT QVVRPTSDAT 250 260 270 280 290 300 AVLFSDAGTD AVGQPYIPDR SQSEIPALDS ATEQGQFTNT PTKDSVLDRE YVAAYTTVPG 310 320 330 340 350 360 KNWVVVKHAP SESAFALSNQ IRTGILGFIL VALVGVVLVG GTIGRNTAAA VQSLSAAAAE 370 380 390 400 410 420 IEAGNYDVDV ASSRRDEIGQ LFASIGSMRD ALVTQIDEAE AAREQATEAQ QDAEAERERA 430 440 450 460 470 480 EDARERAEDA KADAEALAAE LEAQAERYSD VMAACADGDL TRRMPADDTD NEAMAAIAAS 490 500 510 520 530 540 FNEMLAQWEH TIIDIQEFAD AVATASEEAE VGAADAERAS GQVSESVQEI AGAADEQRNM 550 560 570 580 590 600 LDTVSGEMTD LSAAIEEVAA SADSVAEHSH QTAEIARDGE QTAEDAIERS LTVQEAIDAT 610 620 630 640 650 660 VQNVEALDDQ MAEISEIVDL ISDIAEQTNM LALNANIEAA RADKSGDGFA VVADEVKDLA 670 680 690 700 710 720 EETQESAGDI ERRITEVQSQ TTATVAEARA AEESMDAGID AVEEVVDAFT AVSDHADETD 730 740 750 760 770 780 TGVQEISDTT DDQAASTEEA VSMTEEVADL SDSTAGEAQS VSAAAEEQAA SMSEISDSVE 790 800 810 SLSGQAEQLK ALLSEFEVDA DRDVTPTQTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of halobacterial transducer proteins." Rudolph J., Nordmann B., Storch K.F., Gruenberg H., Rodewald K., Oesterhelt D. FEMS Microbiol. Lett. 139:161-168(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S9.
[2]	"Genome sequence of Halobacterium species NRC-1." Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S. Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700922 / JCM 11081 / NRC-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X95589 Genomic DNA. Translation: CAA64841.1. AE004437 Genomic DNA. Translation: AAG19986.1.
PIR	F84327. T46810.
RefSeq	NP_280506.1. NC_002607.1.
3D structure databases
ProteinModelPortal	Q9HP84.
ModBase	Search...
Protein-protein interaction databases
STRING	64091.VNG1760G.
Proteomic databases
PaxDb	Q9HP84.
PRIDE	Q9HP84.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAG19986; AAG19986; VNG_1760G.
GeneID	1448288.
KEGG	hal:VNG1760G.
Phylogenomic databases
eggNOG	COG0840.
OMA	HADSINE.
ProtClustDB	CLSK2300708.
Family and domain databases
InterPro	IPR003660. HAMP_linker_domain. IPR004089. MCPsignal_dom. [Graphical view]
Pfam	PF00672. HAMP. 1 hit. PF00015. MCPsignal. 1 hit. [Graphical view]
SMART	SM00304. HAMP. 3 hits. SM00283. MA. 1 hit. [Graphical view]
PROSITE	PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit. PS50885. HAMP. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HTR4_HALSA

Accession

Primary (citable) accession number: Q9HP84
Secondary accession number(s): Q48317

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	January 11, 2001
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program