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Protein

Transducer protein CosT

Gene

cosT

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mediates chemotaxis towards compatible osmolytes. Probably transduces the signal from the substrate-binding protein CosB to the histidine kinase CheA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Transducer protein CosT
Alternative name(s):
Compatible solute transducer protein
HTP IV
Gene namesi
Name:cosT
Synonyms:htpIV, htr5
Ordered Locus Names:VNG_1760G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 323ExtracellularSequence analysisAdd BLAST264
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 810CytoplasmicSequence analysisAdd BLAST466

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001105511 – 810Transducer protein CosTAdd BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei556Glutamate methyl ester (Glu)By similarity1
Modified residuei739Glutamate methyl ester (Glu)By similarity1

Post-translational modificationi

Methylated by CheR.By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9HP84.
PRIDEiQ9HP84.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1760G.

Structurei

3D structure databases

ProteinModelPortaliQ9HP84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini345 – 397HAMP 1PROSITE-ProRule annotationAdd BLAST53
Domaini439 – 493HAMP 2PROSITE-ProRule annotationAdd BLAST55
Domaini512 – 748Methyl-accepting transducerPROSITE-ProRule annotationAdd BLAST237

Sequence similaritiesi

Contains 2 HAMP domains.PROSITE-ProRule annotation
Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4102TSC. Archaea.
ENOG410XNRY. LUCA.
InParanoidiQ9HP84.
OMAiRHAQNCY.
PhylomeDBiQ9HP84.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
SMARTiSM00304. HAMP. 3 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HP84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPTADAGD NSPSSTDTAP LDRVKAIALL PLRSYLVKFA VALLVILVII
60 70 80 90 100
AAGGFWVQAD ATATLEANTE QQLEQEAVSD ATEIGDWLER NEQSVLIASN
110 120 130 140 150
NPRLGFNTTA ADKQAYVTQL VAAELDADRI ADVHVADPTV GGASDARIVA
160 170 180 190 200
STDEDARGTR VSADTHPWVD RTRSIGRDTV VSTNPYRTAG GQRVVSSMSV
210 220 230 240 250
AADLTHVLVV EYTAGDLSDQ FGAGIDGTFT QVVRPTSDAT AVLFSDAGTD
260 270 280 290 300
AVGQPYIPDR SQSEIPALDS ATEQGQFTNT PTKDSVLDRE YVAAYTTVPG
310 320 330 340 350
KNWVVVKHAP SESAFALSNQ IRTGILGFIL VALVGVVLVG GTIGRNTAAA
360 370 380 390 400
VQSLSAAAAE IEAGNYDVDV ASSRRDEIGQ LFASIGSMRD ALVTQIDEAE
410 420 430 440 450
AAREQATEAQ QDAEAERERA EDARERAEDA KADAEALAAE LEAQAERYSD
460 470 480 490 500
VMAACADGDL TRRMPADDTD NEAMAAIAAS FNEMLAQWEH TIIDIQEFAD
510 520 530 540 550
AVATASEEAE VGAADAERAS GQVSESVQEI AGAADEQRNM LDTVSGEMTD
560 570 580 590 600
LSAAIEEVAA SADSVAEHSH QTAEIARDGE QTAEDAIERS LTVQEAIDAT
610 620 630 640 650
VQNVEALDDQ MAEISEIVDL ISDIAEQTNM LALNANIEAA RADKSGDGFA
660 670 680 690 700
VVADEVKDLA EETQESAGDI ERRITEVQSQ TTATVAEARA AEESMDAGID
710 720 730 740 750
AVEEVVDAFT AVSDHADETD TGVQEISDTT DDQAASTEEA VSMTEEVADL
760 770 780 790 800
SDSTAGEAQS VSAAAEEQAA SMSEISDSVE SLSGQAEQLK ALLSEFEVDA
810
DRDVTPTQTD
Length:810
Mass (Da):85,219
Last modified:January 11, 2001 - v1
Checksum:i4BF36E4B7D22BD80
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19A → G in CAA64841 (PubMed:8674984).Curated1
Sequence conflicti592T → S in CAA64841 (PubMed:8674984).Curated1
Sequence conflicti735A → S in CAA64841 (PubMed:8674984).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95589 Genomic DNA. Translation: CAA64841.1.
AE004437 Genomic DNA. Translation: AAG19986.1.
PIRiF84327.
T46810.
RefSeqiWP_010903284.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19986; AAG19986; VNG_1760G.
GeneIDi5953905.
KEGGihal:VNG_1760G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95589 Genomic DNA. Translation: CAA64841.1.
AE004437 Genomic DNA. Translation: AAG19986.1.
PIRiF84327.
T46810.
RefSeqiWP_010903284.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HP84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG1760G.

Proteomic databases

PaxDbiQ9HP84.
PRIDEiQ9HP84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG19986; AAG19986; VNG_1760G.
GeneIDi5953905.
KEGGihal:VNG_1760G.

Phylogenomic databases

eggNOGiENOG4102TSC. Archaea.
ENOG410XNRY. LUCA.
InParanoidiQ9HP84.
OMAiRHAQNCY.
PhylomeDBiQ9HP84.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
SMARTiSM00304. HAMP. 3 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOST_HALSA
AccessioniPrimary (citable) accession number: Q9HP84
Secondary accession number(s): Q48317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.