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Q9HP84

- COST_HALSA

UniProt

Q9HP84 - COST_HALSA

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Protein
Transducer protein CosT
Gene
cosT, htpIV, htr5, VNG_1760G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Mediates chemotaxis towards compatible osmolytes. Probably transduces the signal from the substrate-binding protein CosB to the histidine kinase CheA By similarity.

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Transducer protein CosT
Alternative name(s):
Compatible solute transducer protein
HTP IV
Gene namesi
Name:cosT
Synonyms:htpIV, htr5
Ordered Locus Names:VNG_1760G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Topological domaini60 – 323264Extracellular Reviewed prediction
Add
BLAST
Transmembranei324 – 34421Helical; Reviewed prediction
Add
BLAST
Topological domaini345 – 810466Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 810810Transducer protein CosT
PRO_0000110551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei556 – 5561Glutamate methyl ester (Glu) By similarity
Modified residuei739 – 7391Glutamate methyl ester (Glu) By similarity

Post-translational modificationi

Methylated by CheR By similarity.

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9HP84.
PRIDEiQ9HP84.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1760G.

Structurei

3D structure databases

ProteinModelPortaliQ9HP84.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini345 – 39753HAMP 1
Add
BLAST
Domaini439 – 49355HAMP 2
Add
BLAST
Domaini512 – 748237Methyl-accepting transducer
Add
BLAST

Sequence similaritiesi

Contains 2 HAMP domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0840.
OMAiSEINDSI.
PhylomeDBiQ9HP84.

Family and domain databases

InterProiIPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
SMARTiSM00304. HAMP. 3 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HP84-1 [UniParc]FASTAAdd to Basket

« Hide

MSEPTADAGD NSPSSTDTAP LDRVKAIALL PLRSYLVKFA VALLVILVII    50
AAGGFWVQAD ATATLEANTE QQLEQEAVSD ATEIGDWLER NEQSVLIASN 100
NPRLGFNTTA ADKQAYVTQL VAAELDADRI ADVHVADPTV GGASDARIVA 150
STDEDARGTR VSADTHPWVD RTRSIGRDTV VSTNPYRTAG GQRVVSSMSV 200
AADLTHVLVV EYTAGDLSDQ FGAGIDGTFT QVVRPTSDAT AVLFSDAGTD 250
AVGQPYIPDR SQSEIPALDS ATEQGQFTNT PTKDSVLDRE YVAAYTTVPG 300
KNWVVVKHAP SESAFALSNQ IRTGILGFIL VALVGVVLVG GTIGRNTAAA 350
VQSLSAAAAE IEAGNYDVDV ASSRRDEIGQ LFASIGSMRD ALVTQIDEAE 400
AAREQATEAQ QDAEAERERA EDARERAEDA KADAEALAAE LEAQAERYSD 450
VMAACADGDL TRRMPADDTD NEAMAAIAAS FNEMLAQWEH TIIDIQEFAD 500
AVATASEEAE VGAADAERAS GQVSESVQEI AGAADEQRNM LDTVSGEMTD 550
LSAAIEEVAA SADSVAEHSH QTAEIARDGE QTAEDAIERS LTVQEAIDAT 600
VQNVEALDDQ MAEISEIVDL ISDIAEQTNM LALNANIEAA RADKSGDGFA 650
VVADEVKDLA EETQESAGDI ERRITEVQSQ TTATVAEARA AEESMDAGID 700
AVEEVVDAFT AVSDHADETD TGVQEISDTT DDQAASTEEA VSMTEEVADL 750
SDSTAGEAQS VSAAAEEQAA SMSEISDSVE SLSGQAEQLK ALLSEFEVDA 800
DRDVTPTQTD 810
Length:810
Mass (Da):85,219
Last modified:January 11, 2001 - v1
Checksum:i4BF36E4B7D22BD80
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191A → G in CAA64841. 1 Publication
Sequence conflicti592 – 5921T → S in CAA64841. 1 Publication
Sequence conflicti735 – 7351A → S in CAA64841. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95589 Genomic DNA. Translation: CAA64841.1.
AE004437 Genomic DNA. Translation: AAG19986.1.
PIRiF84327.
T46810.
RefSeqiNP_280506.1. NC_002607.1.
WP_010903284.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19986; AAG19986; VNG_1760G.
GeneIDi1448288.
KEGGihal:VNG1760G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95589 Genomic DNA. Translation: CAA64841.1 .
AE004437 Genomic DNA. Translation: AAG19986.1 .
PIRi F84327.
T46810.
RefSeqi NP_280506.1. NC_002607.1.
WP_010903284.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HP84.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG1760G.

Proteomic databases

PaxDbi Q9HP84.
PRIDEi Q9HP84.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG19986 ; AAG19986 ; VNG_1760G .
GeneIDi 1448288.
KEGGi hal:VNG1760G.

Phylogenomic databases

eggNOGi COG0840.
OMAi SEINDSI.
PhylomeDBi Q9HP84.

Family and domain databases

InterProi IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view ]
Pfami PF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view ]
SMARTi SM00304. HAMP. 3 hits.
SM00283. MA. 1 hit.
[Graphical view ]
PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: R1 / S9.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiCOST_HALSA
AccessioniPrimary (citable) accession number: Q9HP84
Secondary accession number(s): Q48317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi