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Q9HP84 (COST_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transducer protein CosT
Alternative name(s):
Compatible solute transducer protein
HTP IV
Gene names
Name:cosT
Synonyms:htpIV, htr5
Ordered Locus Names:VNG_1760G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length810 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mediates chemotaxis towards compatible osmolytes. Probably transduces the signal from the substrate-binding protein CosB to the histidine kinase CheA By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Post-translational modification

Methylated by CheR By similarity.

Sequence similarities

Contains 2 HAMP domains.

Contains 1 methyl-accepting transducer domain.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentCell membrane
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Molecular functionTransducer
   PTMMethylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsignal transducer activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 810810Transducer protein CosT
PRO_0000110551

Regions

Topological domain1 – 3838Cytoplasmic Potential
Transmembrane39 – 5921Helical; Potential
Topological domain60 – 323264Extracellular Potential
Transmembrane324 – 34421Helical; Potential
Topological domain345 – 810466Cytoplasmic Potential
Domain345 – 39753HAMP 1
Domain439 – 49355HAMP 2
Domain512 – 748237Methyl-accepting transducer

Amino acid modifications

Modified residue5561Glutamate methyl ester (Glu) By similarity
Modified residue7391Glutamate methyl ester (Glu) By similarity

Experimental info

Sequence conflict191A → G in CAA64841. Ref.1
Sequence conflict5921T → S in CAA64841. Ref.1
Sequence conflict7351A → S in CAA64841. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9HP84 [UniParc].

Last modified January 11, 2001. Version 1.
Checksum: 4BF36E4B7D22BD80

FASTA81085,219
        10         20         30         40         50         60 
MSEPTADAGD NSPSSTDTAP LDRVKAIALL PLRSYLVKFA VALLVILVII AAGGFWVQAD 

        70         80         90        100        110        120 
ATATLEANTE QQLEQEAVSD ATEIGDWLER NEQSVLIASN NPRLGFNTTA ADKQAYVTQL 

       130        140        150        160        170        180 
VAAELDADRI ADVHVADPTV GGASDARIVA STDEDARGTR VSADTHPWVD RTRSIGRDTV 

       190        200        210        220        230        240 
VSTNPYRTAG GQRVVSSMSV AADLTHVLVV EYTAGDLSDQ FGAGIDGTFT QVVRPTSDAT 

       250        260        270        280        290        300 
AVLFSDAGTD AVGQPYIPDR SQSEIPALDS ATEQGQFTNT PTKDSVLDRE YVAAYTTVPG 

       310        320        330        340        350        360 
KNWVVVKHAP SESAFALSNQ IRTGILGFIL VALVGVVLVG GTIGRNTAAA VQSLSAAAAE 

       370        380        390        400        410        420 
IEAGNYDVDV ASSRRDEIGQ LFASIGSMRD ALVTQIDEAE AAREQATEAQ QDAEAERERA 

       430        440        450        460        470        480 
EDARERAEDA KADAEALAAE LEAQAERYSD VMAACADGDL TRRMPADDTD NEAMAAIAAS 

       490        500        510        520        530        540 
FNEMLAQWEH TIIDIQEFAD AVATASEEAE VGAADAERAS GQVSESVQEI AGAADEQRNM 

       550        560        570        580        590        600 
LDTVSGEMTD LSAAIEEVAA SADSVAEHSH QTAEIARDGE QTAEDAIERS LTVQEAIDAT 

       610        620        630        640        650        660 
VQNVEALDDQ MAEISEIVDL ISDIAEQTNM LALNANIEAA RADKSGDGFA VVADEVKDLA 

       670        680        690        700        710        720 
EETQESAGDI ERRITEVQSQ TTATVAEARA AEESMDAGID AVEEVVDAFT AVSDHADETD 

       730        740        750        760        770        780 
TGVQEISDTT DDQAASTEEA VSMTEEVADL SDSTAGEAQS VSAAAEEQAA SMSEISDSVE 

       790        800        810 
SLSGQAEQLK ALLSEFEVDA DRDVTPTQTD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X95589 Genomic DNA. Translation: CAA64841.1.
AE004437 Genomic DNA. Translation: AAG19986.1.
PIRF84327.
T46810.
RefSeqNP_280506.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HP84.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG1760G.

Proteomic databases

PaxDbQ9HP84.
PRIDEQ9HP84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG19986; AAG19986; VNG_1760G.
GeneID1448288.
KEGGhal:VNG1760G.

Phylogenomic databases

eggNOGCOG0840.
OMASEINDSI.
PhylomeDBQ9HP84.

Family and domain databases

InterProIPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
SMARTSM00304. HAMP. 3 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOST_HALSA
AccessionPrimary (citable) accession number: Q9HP84
Secondary accession number(s): Q48317
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families