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Q9HP81 (HTR2_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sensory rhodopsin II transducer
Alternative name(s):
HTR-II
Methyl-accepting phototaxis protein II
Short name=MPP-II
Gene names
Name:htr2
Synonyms:htrII
Ordered Locus Names:VNG_1765G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length764 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transduces signals from the phototaxis receptor sensory rhodopsin II (SR-II) to the flagellar motor. Responds to light changes through the variation of the level of methylation. Also acts as a chemotransducer. Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Contains 2 HAMP domains.

Contains 1 methyl-accepting transducer domain.

Ontologies

Keywords
   Biological processChemotaxis
Sensory transduction
   Cellular componentCell membrane
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandChromophore
   Molecular functionPhotoreceptor protein
Receptor
Transducer
   PTMMethylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

protein-chromophore linkage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphotoreceptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 764763Sensory rhodopsin II transducer
PRO_0000110549

Regions

Topological domain2 – 1615Cytoplasmic Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 278241Extracellular Potential
Transmembrane279 – 29820Helical; Potential
Topological domain299 – 764466Cytoplasmic Potential
Domain303 – 35553HAMP 1
Domain397 – 45054HAMP 2
Domain469 – 705237Methyl-accepting transducer

Experimental info

Sequence conflict107 – 1104VVAA → RWFAG in AAC44369. Ref.1
Sequence conflict6821E → Q in AAC44369. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9HP81 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: D5EB26F706576996

FASTA76479,042
        10         20         30         40         50         60 
MGSGLVARIR GSYGTKLTLA LVVVVVLSVG VGTFVYQQTT TQLETDVRAD LTGSADARAD 

        70         80         90        100        110        120 
HLDAWLSNAR GQTQLASRHP VLASGNDTAI TRYLEGLAAS DERPDGVVAA HVYNTSTTTI 

       130        140        150        160        170        180 
EASSADAFTG VNPREQGAPF ATDPPSFATT SDVVVAAPFT VPAADFPVLS VLSPIPGTTD 

       190        200        210        220        230        240 
KALIYMVNVN TLTDDFGQNV AGSTTTVVSA DGTYVSHPDQ DRVLTGHDGP SRLLNQSRTQ 

       250        260        270        280        290        300 
PAYIDANGTV TAAAPVDGAP WSVLVRAPHD RAFALGDFVA SSLVGLVLIT IVSLSLIGVT 

       310        320        330        340        350        360 
VGSTTVTALR QFSRRADEMA AGDLDTDIDT SRNDEFGTLA ESFRSMRDSL SESLTDAERA 

       370        380        390        400        410        420 
TARAEDARED AEQQRADAEA AREDAEAARK DAQETARALE SAAADYEEAL TAVADGDLTR 

       430        440        450        460        470        480 
RVDASRDHDA MARIGHALND MLDDIETSVA AATAFSDHVS DAAQRVEADA GDAIDAGTDV 

       490        500        510        520        530        540 
STAVDEISDG ATEQTDRLHE VAGEVDDLSA SAEEVAETVA SLADTAGQAA SAVDDGRQAT 

       550        560        570        580        590        600 
EDAVETMDDV ADDAEAAADA MDALDSEMAD IGEIVDVIAD IADQTNMLAL NASIEAARTG 

       610        620        630        640        650        660 
ADGDGFAVVA DEVKTLAEES RDAAEDIESR LLALQGQVSD VADEMRATSD TVSDGRATVG 

       670        680        690        700        710        720 
DAATALDDVV SFVADTDTAA GEIRAATDRQ AHAASRVASA VDEVAGISQE TAAQATAVAD 

       730        740        750        760 
SAATQTDTLS SVDDAAADLA DRAAALDDLL AEFDAHDDTE PEDY 

« Hide

References

« Hide 'large scale' references
[1]"The primary structures of the Archaeon Halobacterium salinarium blue light receptor sensory rhodopsin II and its transducer, a methyl-accepting protein."
Zhang W., Brooun A., Mueller M.M., Alam M.
Proc. Natl. Acad. Sci. U.S.A. 93:8230-8235(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Flx15.
[2]"Genome sequence of Halobacterium species NRC-1."
Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. expand/collapse author list , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S.
Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700922 / JCM 11081 / NRC-1.
[3]"Sensory rhodopsin II transducer HtrII is also responsible for serine chemotaxis in the archaeon Halobacterium salinarum."
Hou S., Brooun A., Yu H.S., Freitas T., Alam M.
J. Bacteriol. 180:1600-1602(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U62676 Genomic DNA. Translation: AAC44369.1.
AE004437 Genomic DNA. Translation: AAG19989.1.
PIRA84328.
T44946.
RefSeqNP_280509.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HP81.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG1765G.

Proteomic databases

PaxDbQ9HP81.
PRIDEQ9HP81.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG19989; AAG19989; VNG_1765G.
GeneID1448291.
KEGGhal:VNG1765G.

Phylogenomic databases

eggNOGCOG0840.
OMAVETMEST.
PhylomeDBQ9HP81.
ProtClustDBCLSK242625.

Family and domain databases

InterProIPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
SMARTSM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHTR2_HALSA
AccessionPrimary (citable) accession number: Q9HP81
Secondary accession number(s): P71410
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families