Q9HP81 (HTR2_HALSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sensory rhodopsin II transducer

Alternative name(s):
HTR-II
Methyl-accepting phototaxis protein II
Short name=MPP-II

Gene names

Name:	htr2
Synonyms:	htrII
Ordered Locus Names:	VNG_1765G

Organism

Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]

Taxonomic identifier

64091 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium › Halobacterium salinarum

Protein attributes

Sequence length	764 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transduces signals from the phototaxis receptor sensory rhodopsin II (SR-II) to the flagellar motor. Responds to light changes through the variation of the level of methylation. Also acts as a chemotransducer. Ref.3
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Contains 2 HAMP domains. Contains 1 methyl-accepting transducer domain.

Ontologies

Keywords
Biological process	Chemotaxis Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Chromophore
Molecular function	Photoreceptor protein Receptor Transducer
PTM	Methylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW protein-chromophore linkage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	photoreceptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 764	763	Sensory rhodopsin II transducer		PRO_0000110549
Regions
	Topological domain	2 – 16	15	Cytoplasmic Potential
	Transmembrane	17 – 37	21	Helical; Potential
	Topological domain	38 – 278	241	Extracellular Potential
	Transmembrane	279 – 298	20	Helical; Potential
	Topological domain	299 – 764	466	Cytoplasmic Potential
	Domain	303 – 355	53	HAMP 1
	Domain	397 – 450	54	HAMP 2
	Domain	469 – 705	237	Methyl-accepting transducer
Experimental info
	Sequence conflict	107 – 110	4	VVAA → RWFAG in AAC44369. Ref.1
	Sequence conflict	682	1	E → Q in AAC44369. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9HP81 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: D5EB26F706576996	FASTA	764	79,042
	10 20 30 40 50 60 MGSGLVARIR GSYGTKLTLA LVVVVVLSVG VGTFVYQQTT TQLETDVRAD LTGSADARAD 70 80 90 100 110 120 HLDAWLSNAR GQTQLASRHP VLASGNDTAI TRYLEGLAAS DERPDGVVAA HVYNTSTTTI 130 140 150 160 170 180 EASSADAFTG VNPREQGAPF ATDPPSFATT SDVVVAAPFT VPAADFPVLS VLSPIPGTTD 190 200 210 220 230 240 KALIYMVNVN TLTDDFGQNV AGSTTTVVSA DGTYVSHPDQ DRVLTGHDGP SRLLNQSRTQ 250 260 270 280 290 300 PAYIDANGTV TAAAPVDGAP WSVLVRAPHD RAFALGDFVA SSLVGLVLIT IVSLSLIGVT 310 320 330 340 350 360 VGSTTVTALR QFSRRADEMA AGDLDTDIDT SRNDEFGTLA ESFRSMRDSL SESLTDAERA 370 380 390 400 410 420 TARAEDARED AEQQRADAEA AREDAEAARK DAQETARALE SAAADYEEAL TAVADGDLTR 430 440 450 460 470 480 RVDASRDHDA MARIGHALND MLDDIETSVA AATAFSDHVS DAAQRVEADA GDAIDAGTDV 490 500 510 520 530 540 STAVDEISDG ATEQTDRLHE VAGEVDDLSA SAEEVAETVA SLADTAGQAA SAVDDGRQAT 550 560 570 580 590 600 EDAVETMDDV ADDAEAAADA MDALDSEMAD IGEIVDVIAD IADQTNMLAL NASIEAARTG 610 620 630 640 650 660 ADGDGFAVVA DEVKTLAEES RDAAEDIESR LLALQGQVSD VADEMRATSD TVSDGRATVG 670 680 690 700 710 720 DAATALDDVV SFVADTDTAA GEIRAATDRQ AHAASRVASA VDEVAGISQE TAAQATAVAD 730 740 750 760 SAATQTDTLS SVDDAAADLA DRAAALDDLL AEFDAHDDTE PEDY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The primary structures of the Archaeon Halobacterium salinarium blue light receptor sensory rhodopsin II and its transducer, a methyl-accepting protein." Zhang W., Brooun A., Mueller M.M., Alam M. Proc. Natl. Acad. Sci. U.S.A. 93:8230-8235(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Flx15.
[2]	"Genome sequence of Halobacterium species NRC-1." Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S. Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700922 / JCM 11081 / NRC-1.
[3]	"Sensory rhodopsin II transducer HtrII is also responsible for serine chemotaxis in the archaeon Halobacterium salinarum." Hou S., Brooun A., Yu H.S., Freitas T., Alam M. J. Bacteriol. 180:1600-1602(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U62676 Genomic DNA. Translation: AAC44369.1. AE004437 Genomic DNA. Translation: AAG19989.1.
PIR	A84328. T44946.
RefSeq	NP_280509.1. NC_002607.1.
3D structure databases
ProteinModelPortal	Q9HP81.
ModBase	Search...
Protein-protein interaction databases
STRING	64091.VNG1765G.
Proteomic databases
PaxDb	Q9HP81.
PRIDE	Q9HP81.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAG19989; AAG19989; VNG_1765G.
GeneID	1448291.
KEGG	hal:VNG1765G.
Phylogenomic databases
eggNOG	COG0840.
OMA	LETIVEY.
ProtClustDB	CLSK242625.
Family and domain databases
InterPro	IPR003660. HAMP_linker_domain. IPR004089. MCPsignal_dom. [Graphical view]
Pfam	PF00672. HAMP. 1 hit. PF00015. MCPsignal. 1 hit. [Graphical view]
SMART	SM00304. HAMP. 2 hits. SM00283. MA. 1 hit. [Graphical view]
PROSITE	PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit. PS50885. HAMP. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HTR2_HALSA

Accession

Primary (citable) accession number: Q9HP81
Secondary accession number(s): P71410

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program