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Protein

Sensory rhodopsin II transducer

Gene

htr2

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transduces signals from the phototaxis receptor sensory rhodopsin II (SR-II) to the flagellar motor. Responds to light changes through the variation of the level of methylation. Also acts as a chemotransducer.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Photoreceptor protein, Receptor, Transducer

Keywords - Biological processi

Chemotaxis, Sensory transduction

Keywords - Ligandi

Chromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Sensory rhodopsin II transducer
Alternative name(s):
HTR-II
Methyl-accepting phototaxis protein II
Short name:
MPP-II
Gene namesi
Name:htr2
Synonyms:htrII
Ordered Locus Names:VNG_1765G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 16CytoplasmicSequence analysisAdd BLAST15
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 278ExtracellularSequence analysisAdd BLAST241
Transmembranei279 – 298HelicalSequence analysisAdd BLAST20
Topological domaini299 – 764CytoplasmicSequence analysisAdd BLAST466

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001105492 – 764Sensory rhodopsin II transducerAdd BLAST763

Post-translational modificationi

Methylated by CheR.By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9HP81.
PRIDEiQ9HP81.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1765G.

Structurei

3D structure databases

ProteinModelPortaliQ9HP81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini303 – 355HAMP 1PROSITE-ProRule annotationAdd BLAST53
Domaini397 – 450HAMP 2PROSITE-ProRule annotationAdd BLAST54
Domaini469 – 705Methyl-accepting transducerPROSITE-ProRule annotationAdd BLAST237

Sequence similaritiesi

Contains 2 HAMP domains.PROSITE-ProRule annotation
Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4102TSC. Archaea.
ENOG410XNRY. LUCA.
InParanoidiQ9HP81.
OMAiTIVEYTE.
PhylomeDBiQ9HP81.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
SMARTiSM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HP81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGLVARIR GSYGTKLTLA LVVVVVLSVG VGTFVYQQTT TQLETDVRAD
60 70 80 90 100
LTGSADARAD HLDAWLSNAR GQTQLASRHP VLASGNDTAI TRYLEGLAAS
110 120 130 140 150
DERPDGVVAA HVYNTSTTTI EASSADAFTG VNPREQGAPF ATDPPSFATT
160 170 180 190 200
SDVVVAAPFT VPAADFPVLS VLSPIPGTTD KALIYMVNVN TLTDDFGQNV
210 220 230 240 250
AGSTTTVVSA DGTYVSHPDQ DRVLTGHDGP SRLLNQSRTQ PAYIDANGTV
260 270 280 290 300
TAAAPVDGAP WSVLVRAPHD RAFALGDFVA SSLVGLVLIT IVSLSLIGVT
310 320 330 340 350
VGSTTVTALR QFSRRADEMA AGDLDTDIDT SRNDEFGTLA ESFRSMRDSL
360 370 380 390 400
SESLTDAERA TARAEDARED AEQQRADAEA AREDAEAARK DAQETARALE
410 420 430 440 450
SAAADYEEAL TAVADGDLTR RVDASRDHDA MARIGHALND MLDDIETSVA
460 470 480 490 500
AATAFSDHVS DAAQRVEADA GDAIDAGTDV STAVDEISDG ATEQTDRLHE
510 520 530 540 550
VAGEVDDLSA SAEEVAETVA SLADTAGQAA SAVDDGRQAT EDAVETMDDV
560 570 580 590 600
ADDAEAAADA MDALDSEMAD IGEIVDVIAD IADQTNMLAL NASIEAARTG
610 620 630 640 650
ADGDGFAVVA DEVKTLAEES RDAAEDIESR LLALQGQVSD VADEMRATSD
660 670 680 690 700
TVSDGRATVG DAATALDDVV SFVADTDTAA GEIRAATDRQ AHAASRVASA
710 720 730 740 750
VDEVAGISQE TAAQATAVAD SAATQTDTLS SVDDAAADLA DRAAALDDLL
760
AEFDAHDDTE PEDY
Length:764
Mass (Da):79,042
Last modified:January 23, 2007 - v2
Checksum:iD5EB26F706576996
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107 – 110VVAA → RWFAG in AAC44369 (PubMed:8710852).Curated4
Sequence conflicti682E → Q in AAC44369 (PubMed:8710852).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62676 Genomic DNA. Translation: AAC44369.1.
AE004437 Genomic DNA. Translation: AAG19989.1.
PIRiA84328.
T44946.
RefSeqiWP_010903287.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19989; AAG19989; VNG_1765G.
GeneIDi5954313.
KEGGihal:VNG_1765G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62676 Genomic DNA. Translation: AAC44369.1.
AE004437 Genomic DNA. Translation: AAG19989.1.
PIRiA84328.
T44946.
RefSeqiWP_010903287.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HP81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG1765G.

Proteomic databases

PaxDbiQ9HP81.
PRIDEiQ9HP81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG19989; AAG19989; VNG_1765G.
GeneIDi5954313.
KEGGihal:VNG_1765G.

Phylogenomic databases

eggNOGiENOG4102TSC. Archaea.
ENOG410XNRY. LUCA.
InParanoidiQ9HP81.
OMAiTIVEYTE.
PhylomeDBiQ9HP81.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
SMARTiSM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHTR2_HALSA
AccessioniPrimary (citable) accession number: Q9HP81
Secondary accession number(s): P71410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.