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Q9HP81

- HTR2_HALSA

UniProt

Q9HP81 - HTR2_HALSA

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Protein
Sensory rhodopsin II transducer
Gene
htr2, htrII, VNG_1765G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Transduces signals from the phototaxis receptor sensory rhodopsin II (SR-II) to the flagellar motor. Responds to light changes through the variation of the level of methylation. Also acts as a chemotransducer.1 Publication

GO - Molecular functioni

  1. photoreceptor activity Source: UniProtKB-KW

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
  2. protein-chromophore linkage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Photoreceptor protein, Receptor, Transducer

Keywords - Biological processi

Chemotaxis, Sensory transduction

Keywords - Ligandi

Chromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Sensory rhodopsin II transducer
Alternative name(s):
HTR-II
Methyl-accepting phototaxis protein II
Short name:
MPP-II
Gene namesi
Name:htr2
Synonyms:htrII
Ordered Locus Names:VNG_1765G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1615Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Topological domaini38 – 278241Extracellular Reviewed prediction
Add
BLAST
Transmembranei279 – 29820Helical; Reviewed prediction
Add
BLAST
Topological domaini299 – 764466Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 764763Sensory rhodopsin II transducer
PRO_0000110549Add
BLAST

Post-translational modificationi

Methylated by CheR By similarity.

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9HP81.
PRIDEiQ9HP81.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1765G.

Structurei

3D structure databases

ProteinModelPortaliQ9HP81.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini303 – 35553HAMP 1
Add
BLAST
Domaini397 – 45054HAMP 2
Add
BLAST
Domaini469 – 705237Methyl-accepting transducer
Add
BLAST

Sequence similaritiesi

Contains 2 HAMP domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0840.
OMAiIVEQTNM.
PhylomeDBiQ9HP81.

Family and domain databases

InterProiIPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
SMARTiSM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HP81-1 [UniParc]FASTAAdd to Basket

« Hide

MGSGLVARIR GSYGTKLTLA LVVVVVLSVG VGTFVYQQTT TQLETDVRAD    50
LTGSADARAD HLDAWLSNAR GQTQLASRHP VLASGNDTAI TRYLEGLAAS 100
DERPDGVVAA HVYNTSTTTI EASSADAFTG VNPREQGAPF ATDPPSFATT 150
SDVVVAAPFT VPAADFPVLS VLSPIPGTTD KALIYMVNVN TLTDDFGQNV 200
AGSTTTVVSA DGTYVSHPDQ DRVLTGHDGP SRLLNQSRTQ PAYIDANGTV 250
TAAAPVDGAP WSVLVRAPHD RAFALGDFVA SSLVGLVLIT IVSLSLIGVT 300
VGSTTVTALR QFSRRADEMA AGDLDTDIDT SRNDEFGTLA ESFRSMRDSL 350
SESLTDAERA TARAEDARED AEQQRADAEA AREDAEAARK DAQETARALE 400
SAAADYEEAL TAVADGDLTR RVDASRDHDA MARIGHALND MLDDIETSVA 450
AATAFSDHVS DAAQRVEADA GDAIDAGTDV STAVDEISDG ATEQTDRLHE 500
VAGEVDDLSA SAEEVAETVA SLADTAGQAA SAVDDGRQAT EDAVETMDDV 550
ADDAEAAADA MDALDSEMAD IGEIVDVIAD IADQTNMLAL NASIEAARTG 600
ADGDGFAVVA DEVKTLAEES RDAAEDIESR LLALQGQVSD VADEMRATSD 650
TVSDGRATVG DAATALDDVV SFVADTDTAA GEIRAATDRQ AHAASRVASA 700
VDEVAGISQE TAAQATAVAD SAATQTDTLS SVDDAAADLA DRAAALDDLL 750
AEFDAHDDTE PEDY 764
Length:764
Mass (Da):79,042
Last modified:January 23, 2007 - v2
Checksum:iD5EB26F706576996
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1104VVAA → RWFAG in AAC44369. 1 Publication
Sequence conflicti682 – 6821E → Q in AAC44369. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62676 Genomic DNA. Translation: AAC44369.1.
AE004437 Genomic DNA. Translation: AAG19989.1.
PIRiA84328.
T44946.
RefSeqiNP_280509.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19989; AAG19989; VNG_1765G.
GeneIDi1448291.
KEGGihal:VNG1765G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62676 Genomic DNA. Translation: AAC44369.1 .
AE004437 Genomic DNA. Translation: AAG19989.1 .
PIRi A84328.
T44946.
RefSeqi NP_280509.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HP81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG1765G.

Proteomic databases

PaxDbi Q9HP81.
PRIDEi Q9HP81.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG19989 ; AAG19989 ; VNG_1765G .
GeneIDi 1448291.
KEGGi hal:VNG1765G.

Phylogenomic databases

eggNOGi COG0840.
OMAi IVEQTNM.
PhylomeDBi Q9HP81.

Family and domain databases

InterProi IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view ]
Pfami PF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view ]
SMARTi SM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
[Graphical view ]
PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structures of the Archaeon Halobacterium salinarium blue light receptor sensory rhodopsin II and its transducer, a methyl-accepting protein."
    Zhang W., Brooun A., Mueller M.M., Alam M.
    Proc. Natl. Acad. Sci. U.S.A. 93:8230-8235(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Flx15.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.
  3. "Sensory rhodopsin II transducer HtrII is also responsible for serine chemotaxis in the archaeon Halobacterium salinarum."
    Hou S., Brooun A., Yu H.S., Freitas T., Alam M.
    J. Bacteriol. 180:1600-1602(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHTR2_HALSA
AccessioniPrimary (citable) accession number: Q9HP81
Secondary accession number(s): P71410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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