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Q9HP81

- HTR2_HALSA

UniProt

Q9HP81 - HTR2_HALSA

Protein

Sensory rhodopsin II transducer

Gene

htr2

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Transduces signals from the phototaxis receptor sensory rhodopsin II (SR-II) to the flagellar motor. Responds to light changes through the variation of the level of methylation. Also acts as a chemotransducer.1 Publication

    GO - Molecular functioni

    1. photoreceptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW
    2. protein-chromophore linkage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Photoreceptor protein, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis, Sensory transduction

    Keywords - Ligandi

    Chromophore

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sensory rhodopsin II transducer
    Alternative name(s):
    HTR-II
    Methyl-accepting phototaxis protein II
    Short name:
    MPP-II
    Gene namesi
    Name:htr2
    Synonyms:htrII
    Ordered Locus Names:VNG_1765G
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 764763Sensory rhodopsin II transducerPRO_0000110549Add
    BLAST

    Post-translational modificationi

    Methylated by CheR.By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiQ9HP81.
    PRIDEiQ9HP81.

    Interactioni

    Protein-protein interaction databases

    STRINGi64091.VNG1765G.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HP81.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1615CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini38 – 278241ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 764466CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29820HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini303 – 35553HAMP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini397 – 45054HAMP 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini469 – 705237Methyl-accepting transducerPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 HAMP domains.PROSITE-ProRule annotation
    Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0840.
    OMAiIVEQTNM.
    PhylomeDBiQ9HP81.

    Family and domain databases

    InterProiIPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    [Graphical view]
    PfamiPF00672. HAMP. 1 hit.
    PF00015. MCPsignal. 1 hit.
    [Graphical view]
    SMARTiSM00304. HAMP. 2 hits.
    SM00283. MA. 1 hit.
    [Graphical view]
    PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HP81-1 [UniParc]FASTAAdd to Basket

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    MGSGLVARIR GSYGTKLTLA LVVVVVLSVG VGTFVYQQTT TQLETDVRAD    50
    LTGSADARAD HLDAWLSNAR GQTQLASRHP VLASGNDTAI TRYLEGLAAS 100
    DERPDGVVAA HVYNTSTTTI EASSADAFTG VNPREQGAPF ATDPPSFATT 150
    SDVVVAAPFT VPAADFPVLS VLSPIPGTTD KALIYMVNVN TLTDDFGQNV 200
    AGSTTTVVSA DGTYVSHPDQ DRVLTGHDGP SRLLNQSRTQ PAYIDANGTV 250
    TAAAPVDGAP WSVLVRAPHD RAFALGDFVA SSLVGLVLIT IVSLSLIGVT 300
    VGSTTVTALR QFSRRADEMA AGDLDTDIDT SRNDEFGTLA ESFRSMRDSL 350
    SESLTDAERA TARAEDARED AEQQRADAEA AREDAEAARK DAQETARALE 400
    SAAADYEEAL TAVADGDLTR RVDASRDHDA MARIGHALND MLDDIETSVA 450
    AATAFSDHVS DAAQRVEADA GDAIDAGTDV STAVDEISDG ATEQTDRLHE 500
    VAGEVDDLSA SAEEVAETVA SLADTAGQAA SAVDDGRQAT EDAVETMDDV 550
    ADDAEAAADA MDALDSEMAD IGEIVDVIAD IADQTNMLAL NASIEAARTG 600
    ADGDGFAVVA DEVKTLAEES RDAAEDIESR LLALQGQVSD VADEMRATSD 650
    TVSDGRATVG DAATALDDVV SFVADTDTAA GEIRAATDRQ AHAASRVASA 700
    VDEVAGISQE TAAQATAVAD SAATQTDTLS SVDDAAADLA DRAAALDDLL 750
    AEFDAHDDTE PEDY 764
    Length:764
    Mass (Da):79,042
    Last modified:January 23, 2007 - v2
    Checksum:iD5EB26F706576996
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti107 – 1104VVAA → RWFAG in AAC44369. (PubMed:8710852)Curated
    Sequence conflicti682 – 6821E → Q in AAC44369. (PubMed:8710852)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62676 Genomic DNA. Translation: AAC44369.1.
    AE004437 Genomic DNA. Translation: AAG19989.1.
    PIRiA84328.
    T44946.
    RefSeqiNP_280509.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG19989; AAG19989; VNG_1765G.
    GeneIDi1448291.
    KEGGihal:VNG1765G.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62676 Genomic DNA. Translation: AAC44369.1 .
    AE004437 Genomic DNA. Translation: AAG19989.1 .
    PIRi A84328.
    T44946.
    RefSeqi NP_280509.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali Q9HP81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG1765G.

    Proteomic databases

    PaxDbi Q9HP81.
    PRIDEi Q9HP81.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG19989 ; AAG19989 ; VNG_1765G .
    GeneIDi 1448291.
    KEGGi hal:VNG1765G.

    Phylogenomic databases

    eggNOGi COG0840.
    OMAi IVEQTNM.
    PhylomeDBi Q9HP81.

    Family and domain databases

    InterProi IPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    [Graphical view ]
    Pfami PF00672. HAMP. 1 hit.
    PF00015. MCPsignal. 1 hit.
    [Graphical view ]
    SMARTi SM00304. HAMP. 2 hits.
    SM00283. MA. 1 hit.
    [Graphical view ]
    PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The primary structures of the Archaeon Halobacterium salinarium blue light receptor sensory rhodopsin II and its transducer, a methyl-accepting protein."
      Zhang W., Brooun A., Mueller M.M., Alam M.
      Proc. Natl. Acad. Sci. U.S.A. 93:8230-8235(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Flx15.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.
    3. "Sensory rhodopsin II transducer HtrII is also responsible for serine chemotaxis in the archaeon Halobacterium salinarum."
      Hou S., Brooun A., Yu H.S., Freitas T., Alam M.
      J. Bacteriol. 180:1600-1602(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiHTR2_HALSA
    AccessioniPrimary (citable) accession number: Q9HP81
    Secondary accession number(s): P71410
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3