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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Gene

uppS

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33UniRule annotation1
Metal bindingi33MagnesiumUniRule annotation1
Active sitei81Proton acceptorUniRule annotation1
Binding sitei82SubstrateUniRule annotation1
Binding sitei84SubstrateUniRule annotation1
Binding sitei203SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)UniRule annotation (EC:2.5.1.89UniRule annotation)
Alternative name(s):
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:VNG_1779C
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001237291 – 302Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)Add BLAST302

Proteomic databases

PaxDbiQ9HP68.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi64091.VNG1779C.

Structurei

3D structure databases

ProteinModelPortaliQ9HP68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingUniRule annotation4
Regioni78 – 80Substrate bindingUniRule annotation3
Regioni209 – 211Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
InParanoidiQ9HP68.
KOiK15888.
OMAiWAKLKNK.
PhylomeDBiQ9HP68.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HP68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTRLWDAAS AVYERLLTRE IDGAPAHVAV IQDGNRRYAR EHGDDPTDGY
60 70 80 90 100
QSGARTTERV LEWCSDLGVE ELTLYAFSTE NFERPPDQQQ HLFDLLESKL
110 120 130 140 150
REFADADRVH ADRVRIRAIG DTGRLPQRVR DAITYAESRT AGYDGFTLNV
160 170 180 190 200
ALAYGGRDEL LTAARGVADA VAAGDLDPAD IDAQAIESRL HTSPVRDVDL
210 220 230 240 250
IIRTGGDERT SNFLPWHANG SEAAVFFCTP YWPEFSKVDL LRAIRTYESR
260 270 280 290 300
AASWRQTRAK RALALVRALG SEVGEARRVL DRFKGALPDP PEDVEAETQS

AD
Length:302
Mass (Da):33,675
Last modified:March 1, 2001 - v1
Checksum:iE7B2D1DEB2F42684
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20002.1.
PIRiF84329.
RefSeqiWP_010903300.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20002; AAG20002; VNG_1779C.
GeneIDi5953101.
KEGGihal:VNG_1779C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20002.1.
PIRiF84329.
RefSeqiWP_010903300.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HP68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG1779C.

Proteomic databases

PaxDbiQ9HP68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG20002; AAG20002; VNG_1779C.
GeneIDi5953101.
KEGGihal:VNG_1779C.

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
InParanoidiQ9HP68.
KOiK15888.
OMAiWAKLKNK.
PhylomeDBiQ9HP68.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPPS_HALSA
AccessioniPrimary (citable) accession number: Q9HP68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.