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Q9HNX7

- NADK_HALSA

UniProt

Q9HNX7 - NADK_HALSA

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Protein

NAD kinase

Gene

nadK

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton acceptorUniRule annotation
Binding sitei151 – 1511NADUniRule annotation
Binding sitei170 – 1701NADUniRule annotation
Binding sitei172 – 1721NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 682NADUniRule annotation
Nucleotide bindingi140 – 1412NADUniRule annotation
Nucleotide bindingi183 – 1886NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:VNG_1900C
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282NAD kinasePRO_0000120698Add
BLAST

Proteomic databases

PaxDbiQ9HNX7.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1900C.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
InParanoidiQ9HNX7.
KOiK00858.
OMAiNLSERGP.
PhylomeDBiQ9HNX7.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HNX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHVGIVAQRG NERATSLAGE IREQLRALEV TVWVDTATAE ALACAGECGR
60 70 80 90 100
DTTAFTDCDL VVSIGGDGTF LFAARGAGAT PILGVNLGEV GFLNAVAPAD
110 120 130 140 150
AVEAVREEVN RYRETGAVRC REVPRVVAAG DGWASTPALN EVAIQGEQRG
160 170 180 190 200
HGHGVAVDVR VDGSQYEATR ADGVLVATPT GSTAYNLSEG GPLVQPSVDA
210 220 230 240 250
LVVTEMCGAD ALPPLVTGLD SEIRIRVETL DDGGEGRVVV ASDGGRLTRV
260 270 280
DPPVEMTVTA ADEPARVAGP AADFFEALSK LE
Length:282
Mass (Da):29,121
Last modified:March 1, 2001 - v1
Checksum:i5DA1AF25147D7500
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20093.1.
PIRiA84341.
RefSeqiNP_280613.1. NC_002607.1.
WP_010903393.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20093; AAG20093; VNG_1900C.
GeneIDi1448394.
KEGGihal:VNG1900C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20093.1 .
PIRi A84341.
RefSeqi NP_280613.1. NC_002607.1.
WP_010903393.1. NC_002607.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG1900C.

Proteomic databases

PaxDbi Q9HNX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG20093 ; AAG20093 ; VNG_1900C .
GeneIDi 1448394.
KEGGi hal:VNG1900C.

Phylogenomic databases

eggNOGi COG0061.
InParanoidi Q9HNX7.
KOi K00858.
OMAi NLSERGP.
PhylomeDBi Q9HNX7.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiNADK_HALSA
AccessioniPrimary (citable) accession number: Q9HNX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3