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Q9HNU2 (PURQ_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 1

EC=6.3.5.3
Alternative name(s):
Phosphoribosylformylglycinamidine synthase I
Short name=FGAM synthase I
Gene names
Name:purQ
Ordered Locus Names:VNG_1945G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00421

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00421

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00421.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   DomainGlutamine amidotransferase
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

glutamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224Phosphoribosylformylglycinamidine synthase 1 HAMAP-Rule MF_00421
PRO_0000100606

Regions

Domain2 – 224223Glutamine amidotransferase type-1

Sites

Active site851Nucleophile By similarity
Active site2021 By similarity
Active site2041 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HNU2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: E13165BD3136330A

FASTA22422,980
        10         20         30         40         50         60 
MTVAVVRFGG SNCDRDAVRA LAHLGVDAAV AWHDDGLPAD TDGVVVPGGF SYGDYLRAGA 

        70         80         90        100        110        120 
MAAQSPVVAE VRALAADGVP VLGVCNGAQI GCEAGLAPGA FTTNASARFQ CERVHLRVEN 

       130        140        150        160        170        180 
ATTPWTAAYS EGDVLEIPIA HGEGRFEIDD DAYADLVADD RVLFRYCNAD GEVTEAANPN 

       190        200        210        220 
GSTGAVAGVT GDRDHVAVMM PHPERATLPA LGATDGQGIL GAFA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG20128.1.
PIRD84345.
RefSeqNP_280648.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HNU2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG1945G.

Proteomic databases

PaxDbQ9HNU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG20128; AAG20128; VNG_1945G.
GeneID1448430.
KEGGhal:VNG1945G.

Phylogenomic databases

eggNOGCOG0047.
KOK01952.
OMADGLGFFT.
PhylomeDBQ9HNU2.
ProtClustDBPRK03619.

Enzyme and pathway databases

UniPathwayUPA00074; UER00128.

Family and domain databases

HAMAPMF_00421. PurQ.
InterProIPR017926. GATASE.
IPR010075. PRibForGlyAmidine_synth_I.
[Graphical view]
PIRSFPIRSF001586. FGAM_synth_I. 1 hit.
TIGRFAMsTIGR01737. FGAM_synth_I. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePURQ_HALSA
AccessionPrimary (citable) accession number: Q9HNU2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways