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Protein

Probable glucose-6-phosphate isomerase

Gene

pgi

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei272 – 2721Proton donorBy similarity
Active sitei293 – 2931By similarity
Active sitei404 – 4041By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:VNG_1992G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Probable glucose-6-phosphate isomerasePRO_0000180779Add
BLAST

Proteomic databases

PaxDbiQ9HNQ6.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1992G.

Structurei

3D structure databases

ProteinModelPortaliQ9HNQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
InParanoidiQ9HNQ6.
KOiK01810.
OMAiKYNMFKL.
PhylomeDBiQ9HNQ6.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HNQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIDIGAALD ATATPGVPPD ALDRLDDRVA HAHDRITAGM DGDEFGYAAL
60 70 80 90 100
NLPRTVDVDA ITAAADAVAD ADTLVTVGIG GSALGAATLV DALGDDDLDY
110 120 130 140 150
HALDNVDPAH VTRLLDRIDL STSAVHVVSR SGTTAETLAN FLVVRDAMDD
160 170 180 190 200
AGVDWTARTL VTTGDDGPLR ALADTHDLPV LDAPRGVPGR FAALSTVALP
210 220 230 240 250
AAAIAGVDVG ELVAGAADGR AALAGSLEDC SAYAYGATAY ALDQRGAGVN
260 270 280 290 300
AMLPYAERLE TFAEWFAQLW AESLGKDGVG QTPARALGAT DQHSQLQLYR
310 320 330 340 350
AGPRDKLVTM LRPASRPDCA IPEAELADID YLTGGDLGAL LDAEFEATAA
360 370 380 390 400
SLAASGVPTV RVEVPAVDAR SVGRLLFDFE AACVLAGELY GVETFTQPAV
410 420
EWGKNAAREL LRGEDPLPET ETHIVE
Length:426
Mass (Da):44,202
Last modified:March 1, 2001 - v1
Checksum:i00D4A2C5187D8672
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20164.1.
PIRiH84349.
RefSeqiNP_280684.1. NC_002607.1.
WP_010903465.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20164; AAG20164; VNG_1992G.
GeneIDi1448467.
KEGGihal:VNG1992G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20164.1.
PIRiH84349.
RefSeqiNP_280684.1. NC_002607.1.
WP_010903465.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HNQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG1992G.

Proteomic databases

PaxDbiQ9HNQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG20164; AAG20164; VNG_1992G.
GeneIDi1448467.
KEGGihal:VNG1992G.

Phylogenomic databases

eggNOGiCOG0166.
InParanoidiQ9HNQ6.
KOiK01810.
OMAiKYNMFKL.
PhylomeDBiQ9HNQ6.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiG6PI_HALSA
AccessioniPrimary (citable) accession number: Q9HNQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.