Q9HNQ6 (G6PI_HALSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	VNG_1992G

Organism

Halobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)

Taxonomic identifier

64091 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 426	426	Probable glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180779
Sites
	Active site	272	1	Proton donor By similarity
	Active site	293	1	By similarity
	Active site	404	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HNQ6 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 00D4A2C5187D8672	FASTA	426	44,202
	10 20 30 40 50 60 MRIDIGAALD ATATPGVPPD ALDRLDDRVA HAHDRITAGM DGDEFGYAAL NLPRTVDVDA 70 80 90 100 110 120 ITAAADAVAD ADTLVTVGIG GSALGAATLV DALGDDDLDY HALDNVDPAH VTRLLDRIDL 130 140 150 160 170 180 STSAVHVVSR SGTTAETLAN FLVVRDAMDD AGVDWTARTL VTTGDDGPLR ALADTHDLPV 190 200 210 220 230 240 LDAPRGVPGR FAALSTVALP AAAIAGVDVG ELVAGAADGR AALAGSLEDC SAYAYGATAY 250 260 270 280 290 300 ALDQRGAGVN AMLPYAERLE TFAEWFAQLW AESLGKDGVG QTPARALGAT DQHSQLQLYR 310 320 330 340 350 360 AGPRDKLVTM LRPASRPDCA IPEAELADID YLTGGDLGAL LDAEFEATAA SLAASGVPTV 370 380 390 400 410 420 RVEVPAVDAR SVGRLLFDFE AACVLAGELY GVETFTQPAV EWGKNAAREL LRGEDPLPET ETHIVE

References

[1]

"Genome sequence of Halobacterium species NRC-1." Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S. Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed: 11016950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700922 / JCM 11081 / NRC-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004437 Genomic DNA. Translation: AAG20164.1.
PIR	H84349.
RefSeq	NP_280684.1. NC_002607.1.
3D structure databases
ProteinModelPortal	Q9HNQ6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1448467.
GenomeReviews	Gene locus VNG_1992G in contig AE004437_GR.
KEGG	hal:VNG1992G.
NMPDR	fig|64091.1.peg.1709.
Phylogenomic databases
HOGENOM	HBG615843.
OMA	DNLDGLN.
ProtClustDB	CLSK511579.
Enzyme and pathway databases
BioCyc	HSP64091:VNG1992G-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. False negative. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_HALSA

Accession

Primary (citable) accession number: Q9HNQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	March 1, 2001
Last modified:	November 16, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program