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Protein

Pyruvoyl-dependent arginine decarboxylase

Gene

pdaD

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

pyruvateBy similarityNote: Binds 1 pyruvoyl group covalently per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyruvate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvoyl-dependent arginine decarboxylase (EC:4.1.1.19)
Short name:
PvlArgDC
Cleaved into the following 2 chains:
Gene namesi
Name:pdaD
Ordered Locus Names:VNG_1999H
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000233081 – 38Pyruvoyl-dependent arginine decarboxylase subunit betaBy similarityAdd BLAST38
ChainiPRO_000002330939 – 160Pyruvoyl-dependent arginine decarboxylase subunit alphaBy similarityAdd BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39Pyruvic acid (Ser)By similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei38 – 39Cleavage (non-hydrolytic)By similarity2

Proteomic databases

PaxDbiQ9HNQ0.
PRIDEiQ9HNQ0.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1999H.

Structurei

3D structure databases

ProteinModelPortaliQ9HNQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdaD family.Curated

Phylogenomic databases

eggNOGiarCOG04490. Archaea.
COG1945. LUCA.
InParanoidiQ9HNQ0.
KOiK02626.
OMAiTIRVVWG.

Family and domain databases

Gene3Di3.50.20.10. 1 hit.
InterProiIPR016104. Pyr-dep_his/arg-deCO2ase.
IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
IPR002724. Pyruvoyl-dep_arg_deCO2ase.
[Graphical view]
PfamiPF01862. PvlArgDC. 1 hit.
[Graphical view]
PIRSFiPIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDomiPD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56271. SSF56271. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HNQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRIRIAWGS GVAPTEMAAY DAALADANVH NYNLIRVSSV IPADATVSPV
60 70 80 90 100
DTAPDLGPAG NTLTVVEARG QTAGPGQASA GLAWAPRDGA PGLFYEAADE
110 120 130 140 150
TTPDDVADRV TTGITAGMDV RDWDGVEPSV RTETVTADAG EHAAAVVIAA
160
YGDSDPVFDQ
Length:160
Mass (Da):16,364
Last modified:March 1, 2001 - v1
Checksum:iB77749F3A1E97BCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20170.1.
PIRiF84350.
RefSeqiWP_010903471.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20170; AAG20170; VNG_1999H.
GeneIDi5953199.
KEGGihal:VNG_1999H.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20170.1.
PIRiF84350.
RefSeqiWP_010903471.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HNQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG1999H.

Proteomic databases

PaxDbiQ9HNQ0.
PRIDEiQ9HNQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG20170; AAG20170; VNG_1999H.
GeneIDi5953199.
KEGGihal:VNG_1999H.

Phylogenomic databases

eggNOGiarCOG04490. Archaea.
COG1945. LUCA.
InParanoidiQ9HNQ0.
KOiK02626.
OMAiTIRVVWG.

Family and domain databases

Gene3Di3.50.20.10. 1 hit.
InterProiIPR016104. Pyr-dep_his/arg-deCO2ase.
IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
IPR002724. Pyruvoyl-dep_arg_deCO2ase.
[Graphical view]
PfamiPF01862. PvlArgDC. 1 hit.
[Graphical view]
PIRSFiPIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDomiPD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56271. SSF56271. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDAD_HALSA
AccessioniPrimary (citable) accession number: Q9HNQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.