Q9HNQ0 (PDAD_HALSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvoyl-dependent arginine decarboxylase
Short name=PvlArgDC
EC=4.1.1.19

Cleaved into the following 2 chains:

1. Pyruvoyl-dependent arginine decarboxylase subunit beta
2. Pyruvoyl-dependent arginine decarboxylase subunit alpha

Gene names

Name:	pdaD
Ordered Locus Names:	VNG_1999H

Organism

Halobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)

Taxonomic identifier

64091 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity. HAMAP MF_01404
Sequence similarities	Belongs to the pdaD family.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 38	38	Pyruvoyl-dependent arginine decarboxylase subunit beta By similarity		PRO_0000023308
	Chain	39 – 160	122	Pyruvoyl-dependent arginine decarboxylase subunit alpha By similarity		PRO_0000023309
Sites
	Site	38 – 39	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	39	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HNQ0 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: B77749F3A1E97BCD	FASTA	160	16,364
	10 20 30 40 50 60 MPRIRIAWGS GVAPTEMAAY DAALADANVH NYNLIRVSSV IPADATVSPV DTAPDLGPAG 70 80 90 100 110 120 NTLTVVEARG QTAGPGQASA GLAWAPRDGA PGLFYEAADE TTPDDVADRV TTGITAGMDV 130 140 150 160 RDWDGVEPSV RTETVTADAG EHAAAVVIAA YGDSDPVFDQ

References

[1]

"Genome sequence of Halobacterium species NRC-1." Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S. Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed: 11016950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700922 / JCM 11081 / NRC-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004437 Genomic DNA. Translation: AAG20170.1.
PIR	F84350.
RefSeq	NP_280690.1. NC_002607.1.
3D structure databases
ProteinModelPortal	Q9HNQ0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1448473.
GenomeReviews	Gene locus VNG_1999H in contig AE004437_GR.
KEGG	hal:VNG1999H.
NMPDR	fig|64091.1.peg.1715.
Phylogenomic databases
HOGENOM	HBG497357.
OMA	GPGLFYE.
ProtClustDB	CLSK511582.
Enzyme and pathway databases
BioCyc	HSP64091:VNG1999H-MONOMER.
Family and domain databases
HAMAP	MF_01404. PvlArgDC. [Tree]
InterPro	IPR016104. Pyr-dep_his/arg-deCO2ase. IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
KO	K02626.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56271. His_carbxylase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD_HALSA

Accession

Primary (citable) accession number: Q9HNQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	March 1, 2001
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program