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Q9HNI2 (GLNA_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

Short name=GS
EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase
Gene names
Name:glnA
Ordered Locus Names:VNG_2093G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulation

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the glutamine synthetase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

nitrogen fixation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454Glutamine synthetase
PRO_0000153202

Amino acid modifications

Modified residue3831O-AMP-tyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HNI2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 09C12E8D0B91D538

FASTA45449,757
        10         20         30         40         50         60 
MTNGDSSSSA LTDNERAVLD DIEAQGIDFL RLQFTDILGT VKNVSIPAHQ AEKAFTEGIY 

        70         80         90        100        110        120 
FDGSSIEGFV RIQESDMRLD PDPETFAVLP WRSNGDGGSA RLICDVVDRE GNAFAGGPRQ 

       130        140        150        160        170        180 
VLKNVLARAD DMGYSVSIGP EPEFFLFEKD DDGNATTTAH DQGGYFDLAP KDLASDIRRE 

       190        200        210        220        230        240 
IIFTLEAMGF EIEASHHEVA RGQHEINFKY DDALTTADNI ATFRAVVRAV AEQHDVHATF 

       250        260        270        280        290        300 
MPKPIGEING SGMHSHISLF DEDGENVFAD NDDEFNLSET AYQFMGGVLE HAPAFTAVTN 

       310        320        330        340        350        360 
PTVNSYKRLV PGYEAPVYIA WSGVNRSALI RVPDAAGVSA RFEIRSPDPS CNPYLALAAV 

       370        380        390        400        410        420 
IAAGLDGIDT DADPGDAVRE DIYEFDEDKR DAYGIDTLPG HLGDAVTALE SDPVMQDALG 

       430        440        450 
EHVCEKFAEA KRHEYAEYKA SVSEWETDRY LEKF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG20238.1.
PIRB84359.
RefSeqNP_280758.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HNI2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG2093G.

Proteomic databases

PaxDbQ9HNI2.
PRIDEQ9HNI2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG20238; AAG20238; VNG_2093G.
GeneID1448542.
KEGGhal:VNG2093G.

Phylogenomic databases

eggNOGCOG0174.
KOK01915.
OMAGEENAFH.
PhylomeDBQ9HNI2.
ProtClustDBCLSK511606.

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
TIGRFAMsTIGR00653. GlnA. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA_HALSA
AccessionPrimary (citable) accession number: Q9HNI2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families