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Q9HNI2

- GLNA_HALSA

UniProt

Q9HNI2 - GLNA_HALSA

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Protein

Glutamine synthetase

Gene

glnA

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:VNG_2093G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Glutamine synthetasePRO_0000153202Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei383 – 3831O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9HNI2.
PRIDEiQ9HNI2.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2093G.

Structurei

3D structure databases

ProteinModelPortaliQ9HNI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
InParanoidiQ9HNI2.
KOiK01915.
OMAiWSGPNRS.
PhylomeDBiQ9HNI2.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HNI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNGDSSSSA LTDNERAVLD DIEAQGIDFL RLQFTDILGT VKNVSIPAHQ
60 70 80 90 100
AEKAFTEGIY FDGSSIEGFV RIQESDMRLD PDPETFAVLP WRSNGDGGSA
110 120 130 140 150
RLICDVVDRE GNAFAGGPRQ VLKNVLARAD DMGYSVSIGP EPEFFLFEKD
160 170 180 190 200
DDGNATTTAH DQGGYFDLAP KDLASDIRRE IIFTLEAMGF EIEASHHEVA
210 220 230 240 250
RGQHEINFKY DDALTTADNI ATFRAVVRAV AEQHDVHATF MPKPIGEING
260 270 280 290 300
SGMHSHISLF DEDGENVFAD NDDEFNLSET AYQFMGGVLE HAPAFTAVTN
310 320 330 340 350
PTVNSYKRLV PGYEAPVYIA WSGVNRSALI RVPDAAGVSA RFEIRSPDPS
360 370 380 390 400
CNPYLALAAV IAAGLDGIDT DADPGDAVRE DIYEFDEDKR DAYGIDTLPG
410 420 430 440 450
HLGDAVTALE SDPVMQDALG EHVCEKFAEA KRHEYAEYKA SVSEWETDRY

LEKF
Length:454
Mass (Da):49,757
Last modified:March 1, 2001 - v1
Checksum:i09C12E8D0B91D538
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20238.1.
PIRiB84359.
RefSeqiNP_280758.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20238; AAG20238; VNG_2093G.
GeneIDi1448542.
KEGGihal:VNG2093G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20238.1 .
PIRi B84359.
RefSeqi NP_280758.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HNI2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG2093G.

Proteomic databases

PaxDbi Q9HNI2.
PRIDEi Q9HNI2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG20238 ; AAG20238 ; VNG_2093G .
GeneIDi 1448542.
KEGGi hal:VNG2093G.

Phylogenomic databases

eggNOGi COG0174.
InParanoidi Q9HNI2.
KOi K01915.
OMAi WSGPNRS.
PhylomeDBi Q9HNI2.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiGLNA_HALSA
AccessioniPrimary (citable) accession number: Q9HNI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3