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Q9HNI2

- GLNA_HALSA

UniProt

Q9HNI2 - GLNA_HALSA

Protein

Glutamine synthetase

Gene

glnA

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Short name:
    GS
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:VNG_2093G
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 454454Glutamine synthetasePRO_0000153202Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei383 – 3831O-AMP-tyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9HNI2.
    PRIDEiQ9HNI2.

    Interactioni

    Protein-protein interaction databases

    STRINGi64091.VNG2093G.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HNI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    KOiK01915.
    OMAiWSGPNRS.
    PhylomeDBiQ9HNI2.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HNI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNGDSSSSA LTDNERAVLD DIEAQGIDFL RLQFTDILGT VKNVSIPAHQ    50
    AEKAFTEGIY FDGSSIEGFV RIQESDMRLD PDPETFAVLP WRSNGDGGSA 100
    RLICDVVDRE GNAFAGGPRQ VLKNVLARAD DMGYSVSIGP EPEFFLFEKD 150
    DDGNATTTAH DQGGYFDLAP KDLASDIRRE IIFTLEAMGF EIEASHHEVA 200
    RGQHEINFKY DDALTTADNI ATFRAVVRAV AEQHDVHATF MPKPIGEING 250
    SGMHSHISLF DEDGENVFAD NDDEFNLSET AYQFMGGVLE HAPAFTAVTN 300
    PTVNSYKRLV PGYEAPVYIA WSGVNRSALI RVPDAAGVSA RFEIRSPDPS 350
    CNPYLALAAV IAAGLDGIDT DADPGDAVRE DIYEFDEDKR DAYGIDTLPG 400
    HLGDAVTALE SDPVMQDALG EHVCEKFAEA KRHEYAEYKA SVSEWETDRY 450
    LEKF 454
    Length:454
    Mass (Da):49,757
    Last modified:March 1, 2001 - v1
    Checksum:i09C12E8D0B91D538
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG20238.1.
    PIRiB84359.
    RefSeqiNP_280758.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG20238; AAG20238; VNG_2093G.
    GeneIDi1448542.
    KEGGihal:VNG2093G.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG20238.1 .
    PIRi B84359.
    RefSeqi NP_280758.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali Q9HNI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG2093G.

    Proteomic databases

    PaxDbi Q9HNI2.
    PRIDEi Q9HNI2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG20238 ; AAG20238 ; VNG_2093G .
    GeneIDi 1448542.
    KEGGi hal:VNG2093G.

    Phylogenomic databases

    eggNOGi COG0174.
    KOi K01915.
    OMAi WSGPNRS.
    PhylomeDBi Q9HNI2.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.

    Entry informationi

    Entry nameiGLNA_HALSA
    AccessioniPrimary (citable) accession number: Q9HNI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3