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Q9HN83 (SYW1_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase 1

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase 1
Short name=TrpRS 1
Gene names
Name:trpS1
Ordered Locus Names:VNG_2208G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence AAG20338.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Tryptophan--tRNA ligase 1 HAMAP-Rule MF_00140
PRO_0000136720

Regions

Motif86 – 949"HIGH" region HAMAP-Rule MF_00140
Motif393 – 3975"KMSKS" region HAMAP-Rule MF_00140

Sequences

Sequence LengthMass (Da)Tools
Q9HN83 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 56C06025F3EE502B

FASTA51356,055
        10         20         30         40         50         60 
MTSDDTDDTA GADDVALDPW GSATISDYRA LFDEFGIEAF EDVLDGVPTP HSLMRRAIIF 

        70         80         90        100        110        120 
GHRDYRRVAA AMRNDEPFAA LSGFMPTGDP HIGHKMVFDE LIWHQQQGGD AYALIADLEA 

       130        140        150        160        170        180 
HSARGLDWAE IDEHAEDYLL SLLALGFDAD EGELYRQSTN RELQDLAFEL GIEANTSEFE 

       190        200        210        220        230        240 
AIYGFGGDTD VSHMQSVVTQ MADILYPQLD APKPTVIPVG PDQDPHVRFA RDLAERTRYF 

       250        260        270        280        290        300 
KVTEAFASVA FDDDERPLVR AAYDARSQYA ADTDQPRCTE AADWLAAEPA AADGVDAATA 

       310        320        330        340        350        360 
ESVVQKLENA GMEPLRPRVR FFDRQATDEA FTALIDEIAG EKRVFEGHVD AFELSAETAR 

       370        380        390        400        410        420 
DLALAVEVDH GGYGFVPPSS VYHRFMTGLT GGKMSSSEPA SHISLLDDPE TGADKVAAAT 

       430        440        450        460        470        480 
TGGRDTAAEQ RERGGEPDDC PVYELYAYLL AGDDDALAEE VYAECANGDR LCGGCKEQAA 

       490        500        510 
DLMAQFLETH QENREAARDV LAELDIDLDS ARV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG20338.1. Different initiation.
PIRF84371.
RefSeqNP_280858.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HN83.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG2208G.

Proteomic databases

PaxDbQ9HN83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG20338; AAG20338; VNG_2208G.
GeneID1448640.
KEGGhal:VNG2208G.

Phylogenomic databases

eggNOGCOG0180.
KOK01867.
OMASIYHRFM.
PhylomeDBQ9HN83.

Family and domain databases

Gene3D3.40.50.620. 2 hits.
HAMAPMF_00140_A. Trp_tRNA_synth_A.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
ProtoNetSearch...

Entry information

Entry nameSYW1_HALSA
AccessionPrimary (citable) accession number: Q9HN83
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries