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Q9HN83

- SYW1_HALSA

UniProt

Q9HN83 - SYW1_HALSA

Protein

Tryptophan--tRNA ligase 1

Gene

trpS1

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase 1UniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetase 1UniRule annotation
    Short name:
    TrpRS 1UniRule annotation
    Gene namesi
    Name:trpS1UniRule annotation
    Ordered Locus Names:VNG_2208G
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Tryptophan--tRNA ligase 1PRO_0000136720Add
    BLAST

    Proteomic databases

    PaxDbiQ9HN83.

    Interactioni

    Protein-protein interaction databases

    STRINGi64091.VNG2208G.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HN83.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi86 – 949"HIGH" region
    Motifi393 – 3975"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    KOiK01867.
    OMAiSIYHRFM.
    PhylomeDBiQ9HN83.

    Family and domain databases

    Gene3Di3.40.50.620. 2 hits.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 2 hits.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.

    Sequencei

    Sequence statusi: Complete.

    Q9HN83-1 [UniParc]FASTAAdd to Basket

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    MTSDDTDDTA GADDVALDPW GSATISDYRA LFDEFGIEAF EDVLDGVPTP    50
    HSLMRRAIIF GHRDYRRVAA AMRNDEPFAA LSGFMPTGDP HIGHKMVFDE 100
    LIWHQQQGGD AYALIADLEA HSARGLDWAE IDEHAEDYLL SLLALGFDAD 150
    EGELYRQSTN RELQDLAFEL GIEANTSEFE AIYGFGGDTD VSHMQSVVTQ 200
    MADILYPQLD APKPTVIPVG PDQDPHVRFA RDLAERTRYF KVTEAFASVA 250
    FDDDERPLVR AAYDARSQYA ADTDQPRCTE AADWLAAEPA AADGVDAATA 300
    ESVVQKLENA GMEPLRPRVR FFDRQATDEA FTALIDEIAG EKRVFEGHVD 350
    AFELSAETAR DLALAVEVDH GGYGFVPPSS VYHRFMTGLT GGKMSSSEPA 400
    SHISLLDDPE TGADKVAAAT TGGRDTAAEQ RERGGEPDDC PVYELYAYLL 450
    AGDDDALAEE VYAECANGDR LCGGCKEQAA DLMAQFLETH QENREAARDV 500
    LAELDIDLDS ARV 513
    Length:513
    Mass (Da):56,055
    Last modified:March 1, 2001 - v1
    Checksum:i56C06025F3EE502B
    GO

    Sequence cautioni

    The sequence AAG20338.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG20338.1. Different initiation.
    PIRiF84371.
    RefSeqiNP_280858.1. NC_002607.1.
    WP_010903639.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG20338; AAG20338; VNG_2208G.
    GeneIDi1448640.
    KEGGihal:VNG2208G.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG20338.1 . Different initiation.
    PIRi F84371.
    RefSeqi NP_280858.1. NC_002607.1.
    WP_010903639.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali Q9HN83.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG2208G.

    Proteomic databases

    PaxDbi Q9HN83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG20338 ; AAG20338 ; VNG_2208G .
    GeneIDi 1448640.
    KEGGi hal:VNG2208G.

    Phylogenomic databases

    eggNOGi COG0180.
    KOi K01867.
    OMAi SIYHRFM.
    PhylomeDBi Q9HN83.

    Family and domain databases

    Gene3Di 3.40.50.620. 2 hits.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 2 hits.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.

    Entry informationi

    Entry nameiSYW1_HALSA
    AccessioniPrimary (citable) accession number: Q9HN83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3