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Protein

Tryptophan--tRNA ligase 1

Gene

trpS1

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase 1UniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetase 1UniRule annotation
Short name:
TrpRS 1UniRule annotation
Gene namesi
Name:trpS1UniRule annotation
Ordered Locus Names:VNG_2208G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Tryptophan--tRNA ligase 1PRO_0000136720Add
BLAST

Proteomic databases

PaxDbiQ9HN83.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2208G.

Structurei

3D structure databases

ProteinModelPortaliQ9HN83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi86 – 949"HIGH" region
Motifi393 – 3975"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
InParanoidiQ9HN83.
KOiK01867.
OMAiSIYHRFM.
PhylomeDBiQ9HN83.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.

Sequencei

Sequence statusi: Complete.

Q9HN83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSDDTDDTA GADDVALDPW GSATISDYRA LFDEFGIEAF EDVLDGVPTP
60 70 80 90 100
HSLMRRAIIF GHRDYRRVAA AMRNDEPFAA LSGFMPTGDP HIGHKMVFDE
110 120 130 140 150
LIWHQQQGGD AYALIADLEA HSARGLDWAE IDEHAEDYLL SLLALGFDAD
160 170 180 190 200
EGELYRQSTN RELQDLAFEL GIEANTSEFE AIYGFGGDTD VSHMQSVVTQ
210 220 230 240 250
MADILYPQLD APKPTVIPVG PDQDPHVRFA RDLAERTRYF KVTEAFASVA
260 270 280 290 300
FDDDERPLVR AAYDARSQYA ADTDQPRCTE AADWLAAEPA AADGVDAATA
310 320 330 340 350
ESVVQKLENA GMEPLRPRVR FFDRQATDEA FTALIDEIAG EKRVFEGHVD
360 370 380 390 400
AFELSAETAR DLALAVEVDH GGYGFVPPSS VYHRFMTGLT GGKMSSSEPA
410 420 430 440 450
SHISLLDDPE TGADKVAAAT TGGRDTAAEQ RERGGEPDDC PVYELYAYLL
460 470 480 490 500
AGDDDALAEE VYAECANGDR LCGGCKEQAA DLMAQFLETH QENREAARDV
510
LAELDIDLDS ARV
Length:513
Mass (Da):56,055
Last modified:March 1, 2001 - v1
Checksum:i56C06025F3EE502B
GO

Sequence cautioni

The sequence AAG20338.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20338.1. Different initiation.
PIRiF84371.
RefSeqiNP_280858.1. NC_002607.1.
WP_010903639.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20338; AAG20338; VNG_2208G.
GeneIDi1448640.
KEGGihal:VNG2208G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20338.1. Different initiation.
PIRiF84371.
RefSeqiNP_280858.1. NC_002607.1.
WP_010903639.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HN83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG2208G.

Proteomic databases

PaxDbiQ9HN83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG20338; AAG20338; VNG_2208G.
GeneIDi1448640.
KEGGihal:VNG2208G.

Phylogenomic databases

eggNOGiCOG0180.
InParanoidiQ9HN83.
KOiK01867.
OMAiSIYHRFM.
PhylomeDBiQ9HN83.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiSYW1_HALSA
AccessioniPrimary (citable) accession number: Q9HN83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.