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Q9HN83

- SYW1_HALSA

UniProt

Q9HN83 - SYW1_HALSA

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Protein

Tryptophan--tRNA ligase 1

Gene
trpS1, VNG_2208G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase 1 (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase 1
Short name:
TrpRS 1
Gene namesi
Name:trpS1
Ordered Locus Names:VNG_2208G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Tryptophan--tRNA ligase 1UniRule annotationPRO_0000136720Add
BLAST

Proteomic databases

PaxDbiQ9HN83.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2208G.

Structurei

3D structure databases

ProteinModelPortaliQ9HN83.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi86 – 949"HIGH" regionUniRule annotation
Motifi393 – 3975"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
KOiK01867.
OMAiSIYHRFM.
PhylomeDBiQ9HN83.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.

Sequencei

Sequence statusi: Complete.

Q9HN83-1 [UniParc]FASTAAdd to Basket

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MTSDDTDDTA GADDVALDPW GSATISDYRA LFDEFGIEAF EDVLDGVPTP    50
HSLMRRAIIF GHRDYRRVAA AMRNDEPFAA LSGFMPTGDP HIGHKMVFDE 100
LIWHQQQGGD AYALIADLEA HSARGLDWAE IDEHAEDYLL SLLALGFDAD 150
EGELYRQSTN RELQDLAFEL GIEANTSEFE AIYGFGGDTD VSHMQSVVTQ 200
MADILYPQLD APKPTVIPVG PDQDPHVRFA RDLAERTRYF KVTEAFASVA 250
FDDDERPLVR AAYDARSQYA ADTDQPRCTE AADWLAAEPA AADGVDAATA 300
ESVVQKLENA GMEPLRPRVR FFDRQATDEA FTALIDEIAG EKRVFEGHVD 350
AFELSAETAR DLALAVEVDH GGYGFVPPSS VYHRFMTGLT GGKMSSSEPA 400
SHISLLDDPE TGADKVAAAT TGGRDTAAEQ RERGGEPDDC PVYELYAYLL 450
AGDDDALAEE VYAECANGDR LCGGCKEQAA DLMAQFLETH QENREAARDV 500
LAELDIDLDS ARV 513
Length:513
Mass (Da):56,055
Last modified:March 1, 2001 - v1
Checksum:i56C06025F3EE502B
GO

Sequence cautioni

The sequence AAG20338.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20338.1. Different initiation.
PIRiF84371.
RefSeqiNP_280858.1. NC_002607.1.
WP_010903639.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20338; AAG20338; VNG_2208G.
GeneIDi1448640.
KEGGihal:VNG2208G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20338.1 . Different initiation.
PIRi F84371.
RefSeqi NP_280858.1. NC_002607.1.
WP_010903639.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HN83.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG2208G.

Proteomic databases

PaxDbi Q9HN83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG20338 ; AAG20338 ; VNG_2208G .
GeneIDi 1448640.
KEGGi hal:VNG2208G.

Phylogenomic databases

eggNOGi COG0180.
KOi K01867.
OMAi SIYHRFM.
PhylomeDBi Q9HN83.

Family and domain databases

Gene3Di 3.40.50.620. 2 hits.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 2 hits.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiSYW1_HALSA
AccessioniPrimary (citable) accession number: Q9HN83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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