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Protein

Tryptophan--tRNA ligase 1

Gene

trpS1

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase 1UniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetase 1UniRule annotation
Short name:
TrpRS 1UniRule annotation
Gene namesi
Name:trpS1UniRule annotation
Ordered Locus Names:VNG_2208G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367201 – 513Tryptophan--tRNA ligase 1Add BLAST513

Proteomic databases

PaxDbiQ9HN83
PRIDEiQ9HN83

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2208G

Structurei

3D structure databases

ProteinModelPortaliQ9HN83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi86 – 94"HIGH" region9
Motifi393 – 397"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
InParanoidiQ9HN83
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z044X
PhylomeDBiQ9HN83

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 2 hits
PRINTSiPR01039 TRNASYNTHTRP

Sequencei

Sequence statusi: Complete.

Q9HN83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSDDTDDTA GADDVALDPW GSATISDYRA LFDEFGIEAF EDVLDGVPTP
60 70 80 90 100
HSLMRRAIIF GHRDYRRVAA AMRNDEPFAA LSGFMPTGDP HIGHKMVFDE
110 120 130 140 150
LIWHQQQGGD AYALIADLEA HSARGLDWAE IDEHAEDYLL SLLALGFDAD
160 170 180 190 200
EGELYRQSTN RELQDLAFEL GIEANTSEFE AIYGFGGDTD VSHMQSVVTQ
210 220 230 240 250
MADILYPQLD APKPTVIPVG PDQDPHVRFA RDLAERTRYF KVTEAFASVA
260 270 280 290 300
FDDDERPLVR AAYDARSQYA ADTDQPRCTE AADWLAAEPA AADGVDAATA
310 320 330 340 350
ESVVQKLENA GMEPLRPRVR FFDRQATDEA FTALIDEIAG EKRVFEGHVD
360 370 380 390 400
AFELSAETAR DLALAVEVDH GGYGFVPPSS VYHRFMTGLT GGKMSSSEPA
410 420 430 440 450
SHISLLDDPE TGADKVAAAT TGGRDTAAEQ RERGGEPDDC PVYELYAYLL
460 470 480 490 500
AGDDDALAEE VYAECANGDR LCGGCKEQAA DLMAQFLETH QENREAARDV
510
LAELDIDLDS ARV
Length:513
Mass (Da):56,055
Last modified:March 1, 2001 - v1
Checksum:i56C06025F3EE502B
GO

Sequence cautioni

The sequence AAG20338 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG20338.1 Different initiation.
PIRiF84371
RefSeqiWP_010903639.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG20338; AAG20338; VNG_2208G
GeneIDi5953293
KEGGihal:VNG_2208G
PATRICifig|64091.14.peg.1698

Similar proteinsi

Entry informationi

Entry nameiSYW1_HALSA
AccessioniPrimary (citable) accession number: Q9HN83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health