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Q9HN72

- SYL_HALSA

UniProt

Q9HN72 - SYL_HALSA

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Protein
Leucine--tRNA ligase
Gene
leuS, VNG_2223G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei574 – 5741ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:VNG_2223G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 885885Leucine--tRNA ligaseUniRule annotation
PRO_0000152129Add
BLAST

Proteomic databases

PaxDbiQ9HN72.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2223G.

Structurei

3D structure databases

ProteinModelPortaliQ9HN72.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi571 – 5755"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiVNIVTND.
PhylomeDBiQ9HN72.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HN72-1 [UniParc]FASTAAdd to Basket

« Hide

MGEQATYDHH AIEQHWQREW DDADVFRVPD DADDPEYVLA MFPYTSGQLH    50
MGHVRNYAIT DAFARYRRMD GEDVLHPMGW DSFGLPAENA ANERDTNPRE 100
WTERCIDQMR DQFEALGFGY DWEREITTCD PDYYKWNQWL FTEFRDAGLV 150
DRRAATVNWC PSCETVLADE QVEGDDELCW RCDTPVTERD LDQWFFETTA 200
YADELLDGLD ELDGWPSNVR DMQRNWVGRT DGVEVPFTVH TPDGDEDVVA 250
FTTRVDTIHG ATYFALAPDH PLAEAAADRD DDVAHFVEEV ADPDGDEPQG 300
VETEFTATNP ATGAEIPVVV ADFVLSDVGT GALMAVPAHD DRDHEFAQAH 350
DLPVRQVVAP AGDEDADVEA AAYTADGVLV NAGDYTGLDS ETAREELTAD 400
IDGAASAVQY QLRDWGVSRQ RYWGTPIPIV HCESCGPVSV PDDDLPVELP 450
EFVHTTGNPL DAAEDWKQTT CPDCGAPAVR ETDTMDTFLD SSWYFLRFAS 500
PAFDDAPFDT QRANDWLPVD EYVGGDEHAV MHLLYSRFVT KAFADLDMLE 550
HREPFAGLTT QGMVLGEDGT KMSKSKDNGV APERIVDEYG ADTARLFTLR 600
AARPSKAFPW SEEGVRSSHT FLERLLSMAR AVNADATADG DLDPAAEYVA 650
RETAATVQAA TTHFDDMEFN RAVQAVDELV SLLVRYRDRD DAAPAVVARG 700
VTAAVKLLAP IAPHVAEECW TALGGDGFVA EAAWPTPDRD VSDHDRATSL 750
IEQTREDVRD IVDTAGIENP TGVDVVTAPE WMYDVLARAK AADGNVVGSV 800
MSDQSLQQHG EDAADYAKDL AAQAPAFPDV LGPDGERDAL GRAVWLLEAE 850
FDAPVRVLAA EDAADSVANK AEPGRPAIHV DEADD 885
Length:885
Mass (Da):97,527
Last modified:March 1, 2001 - v1
Checksum:iCA697263BE4D58F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20349.1.
PIRiA84373.
RefSeqiNP_280869.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20349; AAG20349; VNG_2223G.
GeneIDi1448651.
KEGGihal:VNG2223G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20349.1 .
PIRi A84373.
RefSeqi NP_280869.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HN72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG2223G.

Proteomic databases

PaxDbi Q9HN72.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG20349 ; AAG20349 ; VNG_2223G .
GeneIDi 1448651.
KEGGi hal:VNG2223G.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi VNIVTND.
PhylomeDBi Q9HN72.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiSYL_HALSA
AccessioniPrimary (citable) accession number: Q9HN72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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