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Q9HN72 (SYL_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:VNG_2223G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length885 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 885885Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152129

Regions

Motif43 – 5311"HIGH" region HAMAP-Rule MF_00049
Motif571 – 5755"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5741ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HN72 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: CA697263BE4D58F7

FASTA88597,527
        10         20         30         40         50         60 
MGEQATYDHH AIEQHWQREW DDADVFRVPD DADDPEYVLA MFPYTSGQLH MGHVRNYAIT 

        70         80         90        100        110        120 
DAFARYRRMD GEDVLHPMGW DSFGLPAENA ANERDTNPRE WTERCIDQMR DQFEALGFGY 

       130        140        150        160        170        180 
DWEREITTCD PDYYKWNQWL FTEFRDAGLV DRRAATVNWC PSCETVLADE QVEGDDELCW 

       190        200        210        220        230        240 
RCDTPVTERD LDQWFFETTA YADELLDGLD ELDGWPSNVR DMQRNWVGRT DGVEVPFTVH 

       250        260        270        280        290        300 
TPDGDEDVVA FTTRVDTIHG ATYFALAPDH PLAEAAADRD DDVAHFVEEV ADPDGDEPQG 

       310        320        330        340        350        360 
VETEFTATNP ATGAEIPVVV ADFVLSDVGT GALMAVPAHD DRDHEFAQAH DLPVRQVVAP 

       370        380        390        400        410        420 
AGDEDADVEA AAYTADGVLV NAGDYTGLDS ETAREELTAD IDGAASAVQY QLRDWGVSRQ 

       430        440        450        460        470        480 
RYWGTPIPIV HCESCGPVSV PDDDLPVELP EFVHTTGNPL DAAEDWKQTT CPDCGAPAVR 

       490        500        510        520        530        540 
ETDTMDTFLD SSWYFLRFAS PAFDDAPFDT QRANDWLPVD EYVGGDEHAV MHLLYSRFVT 

       550        560        570        580        590        600 
KAFADLDMLE HREPFAGLTT QGMVLGEDGT KMSKSKDNGV APERIVDEYG ADTARLFTLR 

       610        620        630        640        650        660 
AARPSKAFPW SEEGVRSSHT FLERLLSMAR AVNADATADG DLDPAAEYVA RETAATVQAA 

       670        680        690        700        710        720 
TTHFDDMEFN RAVQAVDELV SLLVRYRDRD DAAPAVVARG VTAAVKLLAP IAPHVAEECW 

       730        740        750        760        770        780 
TALGGDGFVA EAAWPTPDRD VSDHDRATSL IEQTREDVRD IVDTAGIENP TGVDVVTAPE 

       790        800        810        820        830        840 
WMYDVLARAK AADGNVVGSV MSDQSLQQHG EDAADYAKDL AAQAPAFPDV LGPDGERDAL 

       850        860        870        880 
GRAVWLLEAE FDAPVRVLAA EDAADSVANK AEPGRPAIHV DEADD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG20349.1.
PIRA84373.
RefSeqNP_280869.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HN72.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG2223G.

Proteomic databases

PaxDbQ9HN72.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG20349; AAG20349; VNG_2223G.
GeneID1448651.
KEGGhal:VNG2223G.

Phylogenomic databases

eggNOGCOG0495.
KOK01869.
OMAVNIVTND.
PhylomeDBQ9HN72.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_HALSA
AccessionPrimary (citable) accession number: Q9HN72
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries