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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei574ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:VNG_2223G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521291 – 885Leucine--tRNA ligaseAdd BLAST885

Proteomic databases

PaxDbiQ9HN72

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2223G

Structurei

3D structure databases

ProteinModelPortaliQ9HN72
SMRiQ9HN72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi571 – 575"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
InParanoidiQ9HN72
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG093Z008W
PhylomeDBiQ9HN72

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HN72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEQATYDHH AIEQHWQREW DDADVFRVPD DADDPEYVLA MFPYTSGQLH
60 70 80 90 100
MGHVRNYAIT DAFARYRRMD GEDVLHPMGW DSFGLPAENA ANERDTNPRE
110 120 130 140 150
WTERCIDQMR DQFEALGFGY DWEREITTCD PDYYKWNQWL FTEFRDAGLV
160 170 180 190 200
DRRAATVNWC PSCETVLADE QVEGDDELCW RCDTPVTERD LDQWFFETTA
210 220 230 240 250
YADELLDGLD ELDGWPSNVR DMQRNWVGRT DGVEVPFTVH TPDGDEDVVA
260 270 280 290 300
FTTRVDTIHG ATYFALAPDH PLAEAAADRD DDVAHFVEEV ADPDGDEPQG
310 320 330 340 350
VETEFTATNP ATGAEIPVVV ADFVLSDVGT GALMAVPAHD DRDHEFAQAH
360 370 380 390 400
DLPVRQVVAP AGDEDADVEA AAYTADGVLV NAGDYTGLDS ETAREELTAD
410 420 430 440 450
IDGAASAVQY QLRDWGVSRQ RYWGTPIPIV HCESCGPVSV PDDDLPVELP
460 470 480 490 500
EFVHTTGNPL DAAEDWKQTT CPDCGAPAVR ETDTMDTFLD SSWYFLRFAS
510 520 530 540 550
PAFDDAPFDT QRANDWLPVD EYVGGDEHAV MHLLYSRFVT KAFADLDMLE
560 570 580 590 600
HREPFAGLTT QGMVLGEDGT KMSKSKDNGV APERIVDEYG ADTARLFTLR
610 620 630 640 650
AARPSKAFPW SEEGVRSSHT FLERLLSMAR AVNADATADG DLDPAAEYVA
660 670 680 690 700
RETAATVQAA TTHFDDMEFN RAVQAVDELV SLLVRYRDRD DAAPAVVARG
710 720 730 740 750
VTAAVKLLAP IAPHVAEECW TALGGDGFVA EAAWPTPDRD VSDHDRATSL
760 770 780 790 800
IEQTREDVRD IVDTAGIENP TGVDVVTAPE WMYDVLARAK AADGNVVGSV
810 820 830 840 850
MSDQSLQQHG EDAADYAKDL AAQAPAFPDV LGPDGERDAL GRAVWLLEAE
860 870 880
FDAPVRVLAA EDAADSVANK AEPGRPAIHV DEADD
Length:885
Mass (Da):97,527
Last modified:March 1, 2001 - v1
Checksum:iCA697263BE4D58F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG20349.1
PIRiA84373
RefSeqiWP_010903650.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG20349; AAG20349; VNG_2223G
GeneIDi5954103
KEGGihal:VNG_2223G
PATRICifig|64091.14.peg.1709

Similar proteinsi

Entry informationi

Entry nameiSYL_HALSA
AccessioniPrimary (citable) accession number: Q9HN72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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