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Q9HN66 (SYW2_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase 2

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase 2
Short name=TrpRS 2
Gene names
Name:trpS2
Synonyms:trpS
Ordered Locus Names:VNG_2232G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Tryptophan--tRNA ligase 2 HAMAP-Rule MF_00140
PRO_0000136721

Regions

Motif74 – 829"HIGH" region HAMAP-Rule MF_00140
Motif249 – 2535"KMSKS" region HAMAP-Rule MF_00140

Sequences

Sequence LengthMass (Da)Tools
Q9HN66 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 0F7B2B955386404F

FASTA38041,937
        10         20         30         40         50         60 
MTADGNDVTP YAVESDDLDY EKLLARFGAD ELTDDQRARF PDHPLVNRGL FYAGRDVDDF 

        70         80         90        100        110        120 
LTAGEQSIVT GVGPSGPMHL GHAMVFYFAR RLQDEFGARV YVPLSDDEKY WFKDQTPAET 

       130        140        150        160        170        180 
GDYLRANLRD LLAVGFDPEL TRIVVDTRDA DVLYPLATAF AGDVRHATLQ NVYGEPDNVG 

       190        200        210        220        230        240 
QAFYPAVQTA HLLLPQLVHG EHETLVPIAV DQDPHVRVSR DVAAKARYPV GKPGALLMQF 

       250        260        270        280        290        300 
LPSLAGPGKM SSSAGVSIRL TDSPDTVREK VRTHAYTGGR ASVEEHRAKG GVPAEDVPFQ 

       310        320        330        340        350        360 
YLSAFFEPDD AELARIEREY RAGDLLSGEL KDLAADRITE FLAAHQRRRA ALGDVTEALD 

       370        380 
AFRLTDDERQ RARDAVGFGY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG20355.1.
PIRG84373.
RefSeqNP_280875.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HN66.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG2232G.

Proteomic databases

PaxDbQ9HN66.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG20355; AAG20355; VNG_2232G.
GeneID1448657.
KEGGhal:VNG2232G.

Phylogenomic databases

eggNOGCOG0180.
KOK01867.
OMAFYFAKYL.
PhylomeDBQ9HN66.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_A. Trp_tRNA_synth_A.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW2_HALSA
AccessionPrimary (citable) accession number: Q9HN66
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries