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Q9HN66

- SYW2_HALSA

UniProt

Q9HN66 - SYW2_HALSA

Protein

Tryptophan--tRNA ligase 2

Gene

trpS2

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase 2UniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetase 2UniRule annotation
    Short name:
    TrpRS 2UniRule annotation
    Gene namesi
    Name:trpS2UniRule annotation
    Synonyms:trpS
    Ordered Locus Names:VNG_2232G
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Tryptophan--tRNA ligase 2PRO_0000136721Add
    BLAST

    Proteomic databases

    PaxDbiQ9HN66.

    Interactioni

    Protein-protein interaction databases

    STRINGi64091.VNG2232G.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HN66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi74 – 829"HIGH" region
    Motifi249 – 2535"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    KOiK01867.
    OMAiFYFAKYL.
    PhylomeDBiQ9HN66.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HN66-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTADGNDVTP YAVESDDLDY EKLLARFGAD ELTDDQRARF PDHPLVNRGL    50
    FYAGRDVDDF LTAGEQSIVT GVGPSGPMHL GHAMVFYFAR RLQDEFGARV 100
    YVPLSDDEKY WFKDQTPAET GDYLRANLRD LLAVGFDPEL TRIVVDTRDA 150
    DVLYPLATAF AGDVRHATLQ NVYGEPDNVG QAFYPAVQTA HLLLPQLVHG 200
    EHETLVPIAV DQDPHVRVSR DVAAKARYPV GKPGALLMQF LPSLAGPGKM 250
    SSSAGVSIRL TDSPDTVREK VRTHAYTGGR ASVEEHRAKG GVPAEDVPFQ 300
    YLSAFFEPDD AELARIEREY RAGDLLSGEL KDLAADRITE FLAAHQRRRA 350
    ALGDVTEALD AFRLTDDERQ RARDAVGFGY 380
    Length:380
    Mass (Da):41,937
    Last modified:March 1, 2001 - v1
    Checksum:i0F7B2B955386404F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG20355.1.
    PIRiG84373.
    RefSeqiNP_280875.1. NC_002607.1.
    WP_010903656.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG20355; AAG20355; VNG_2232G.
    GeneIDi1448657.
    KEGGihal:VNG2232G.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG20355.1 .
    PIRi G84373.
    RefSeqi NP_280875.1. NC_002607.1.
    WP_010903656.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali Q9HN66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG2232G.

    Proteomic databases

    PaxDbi Q9HN66.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG20355 ; AAG20355 ; VNG_2232G .
    GeneIDi 1448657.
    KEGGi hal:VNG2232G.

    Phylogenomic databases

    eggNOGi COG0180.
    KOi K01867.
    OMAi FYFAKYL.
    PhylomeDBi Q9HN66.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.

    Entry informationi

    Entry nameiSYW2_HALSA
    AccessioniPrimary (citable) accession number: Q9HN66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3