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Q9HN66

- SYW2_HALSA

UniProt

Q9HN66 - SYW2_HALSA

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Protein
Tryptophan--tRNA ligase 2
Gene
trpS2, trpS, VNG_2232G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase 2 (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase 2
Short name:
TrpRS 2
Gene namesi
Name:trpS2
Synonyms:trpS
Ordered Locus Names:VNG_2232G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Tryptophan--tRNA ligase 2UniRule annotation
PRO_0000136721Add
BLAST

Proteomic databases

PaxDbiQ9HN66.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2232G.

Structurei

3D structure databases

ProteinModelPortaliQ9HN66.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi74 – 829"HIGH" regionUniRule annotation
Motifi249 – 2535"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
KOiK01867.
OMAiFYFAKYL.
PhylomeDBiQ9HN66.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HN66-1 [UniParc]FASTAAdd to Basket

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MTADGNDVTP YAVESDDLDY EKLLARFGAD ELTDDQRARF PDHPLVNRGL    50
FYAGRDVDDF LTAGEQSIVT GVGPSGPMHL GHAMVFYFAR RLQDEFGARV 100
YVPLSDDEKY WFKDQTPAET GDYLRANLRD LLAVGFDPEL TRIVVDTRDA 150
DVLYPLATAF AGDVRHATLQ NVYGEPDNVG QAFYPAVQTA HLLLPQLVHG 200
EHETLVPIAV DQDPHVRVSR DVAAKARYPV GKPGALLMQF LPSLAGPGKM 250
SSSAGVSIRL TDSPDTVREK VRTHAYTGGR ASVEEHRAKG GVPAEDVPFQ 300
YLSAFFEPDD AELARIEREY RAGDLLSGEL KDLAADRITE FLAAHQRRRA 350
ALGDVTEALD AFRLTDDERQ RARDAVGFGY 380
Length:380
Mass (Da):41,937
Last modified:March 1, 2001 - v1
Checksum:i0F7B2B955386404F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20355.1.
PIRiG84373.
RefSeqiNP_280875.1. NC_002607.1.
WP_010903656.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20355; AAG20355; VNG_2232G.
GeneIDi1448657.
KEGGihal:VNG2232G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20355.1 .
PIRi G84373.
RefSeqi NP_280875.1. NC_002607.1.
WP_010903656.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HN66.
ModBasei Search...

Protein-protein interaction databases

STRINGi 64091.VNG2232G.

Proteomic databases

PaxDbi Q9HN66.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG20355 ; AAG20355 ; VNG_2232G .
GeneIDi 1448657.
KEGGi hal:VNG2232G.

Phylogenomic databases

eggNOGi COG0180.
KOi K01867.
OMAi FYFAKYL.
PhylomeDBi Q9HN66.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiSYW2_HALSA
AccessioniPrimary (citable) accession number: Q9HN66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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