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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:VNG_2259C
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Phosphoenolpyruvate carboxylasePRO_0000309599Add
BLAST

Proteomic databases

PaxDbiQ9HN43.
PRIDEiQ9HN43.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi64091.VNG2259C.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1892.
InParanoidiQ9HN43.
KOiK01595.
OMAiQSSFKYD.
PhylomeDBiQ9HN43.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HN43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDVPRLMST QHPDNATLPF FTAGDVIEGE DEIQEAYYVY SHLGCDEQMW
60 70 80 90 100
DFEGKEGDEY AVKKLLSRYD EFFADHQLGT DVRLTVRGPN PDVEGSEAKI
110 120 130 140 150
LLEILESIPR SFDAARRFAG EYGLETTAPI FEVIVPMVTD ADQLNAVHEY
160 170 180 190 200
YERFVTGKAD EAVWDGRTVE EWVGEFDPAS ITVIPLIEER EAMLAADDIV
210 220 230 240 250
REYATAHDQD AVRVFLARSD PALNYGCLAA DLINKVALQR LYEMSEATGV
260 270 280 290 300
DVHPILGAGS APFRGNLTPE RAAATADAYS EVETFTVQSA FKYDYPVETV
310 320 330 340 350
RDGVATLRDA DLGAPPFPID EARALAVIDR TADAYADQVD AIAGTVNRLS
360 370 380 390 400
SYVPDRRARK LHVGLFGYAR EVGENALPRA IGYTASLYAV GCPPTLLGAH
410 420 430 440 450
ALTDDDAAFV REAFPAYFDH LADAARYFNP RCTDVLDLDD DTLAAAVERV
460 470 480 490
DVTPNSEHRA ATDDAIDALQ RGDDDALRSA IRRGARERQF LG
Length:492
Mass (Da):54,179
Last modified:March 1, 2001 - v1
Checksum:i12FBE025EF21C6D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20378.1.
PIRiF84376.
RefSeqiNP_280898.1. NC_002607.1.
WP_010903679.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20378; AAG20378; VNG_2259C.
GeneIDi1448680.
KEGGihal:VNG2259C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20378.1.
PIRiF84376.
RefSeqiNP_280898.1. NC_002607.1.
WP_010903679.1. NC_002607.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG2259C.

Proteomic databases

PaxDbiQ9HN43.
PRIDEiQ9HN43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG20378; AAG20378; VNG_2259C.
GeneIDi1448680.
KEGGihal:VNG2259C.

Phylogenomic databases

eggNOGiCOG1892.
InParanoidiQ9HN43.
KOiK01595.
OMAiQSSFKYD.
PhylomeDBiQ9HN43.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiCAPPA_HALSA
AccessioniPrimary (citable) accession number: Q9HN43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2001
Last modified: April 29, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.