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Q9HN23 (HIS3_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19
Gene names
Name:hisI
Synonyms:hisJ
Ordered Locus Names:VNG_2284G
OrganismHalobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021

Subcellular location

Cytoplasm By similarity HAMAP MF_01021.

Sequence similarities

Belongs to the PRA-CH family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionphosphoribosyl-AMP cyclohydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 129129Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021
PRO_0000136505

Sequences

Sequence LengthMass (Da)Tools
Q9HN23 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 8FFC60D17FFF8AB8

FASTA12913,909
        10         20         30         40         50         60 
MEEFDVDLDF GGAGHTDDGD GLVAVIAQDA DSRDVLMLAY ATREAVARTA TTGRAHYYSR 

        70         80         90        100        110        120 
SRDELWEKGA TSGNTQSVDE IRVDCDGDAL LYLVAQTGGA CHTGHESCFH RTLDGDTVGD 


QVFDPDDAY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004437 Genomic DNA. Translation: AAG20398.1.
PIRB84379.
RefSeqNP_280918.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HN23.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1448700.
GenomeReviewsGene locus VNG_2284G in contig AE004437_GR.
KEGGhal:VNG2284G.
NMPDRfig|64091.1.peg.1944.

Phylogenomic databases

HOGENOMHBG294308.
OMAGACHVGY.
PhylomeDBQ9HN23.
ProtClustDBPRK00051.

Enzyme and pathway databases

BioCycHSP64091:VNG2284G-MONOMER.

Family and domain databases

HAMAPMF_01021. HisI.
[Tree]
InterProIPR002496. PRib_AMP_CycHydrolase.
[Graphical view]
KOK01496.
PfamPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameHIS3_HALSA
AccessionPrimary (citable) accession number: Q9HN23
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2001
Last modified: December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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