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Q9HN21

- GMSS_HALSA

UniProt

Q9HN21 - GMSS_HALSA

Protein

Glutamate mutase sigma subunit

Gene

glmS

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).UniRule annotation

    Catalytic activityi

    L-threo-3-methylaspartate = L-glutamate.UniRule annotation

    Cofactori

    Adenosylcobalamin.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi18 – 181Cobalt (cobalamin axial ligand)UniRule annotation

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. methylaspartate mutase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. anaerobic glutamate catabolic process Source: UniProtKB-HAMAP
    2. glutamate catabolic process via L-citramalate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Cobalamin, Cobalt, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00561; UER00617.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate mutase sigma subunitUniRule annotation (EC:5.4.99.1UniRule annotation)
    Alternative name(s):
    Glutamate mutase S chainUniRule annotation
    Glutamate mutase small subunitUniRule annotation
    Methylaspartate mutaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Synonyms:mamA
    Ordered Locus Names:VNG_2286G
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 149149Glutamate mutase sigma subunitPRO_0000216449Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi64091.VNG2286G.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HN21.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 138134B12-bindingUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 195Adenosylcobalamin bindingUniRule annotation
    Regioni63 – 653Adenosylcobalamin bindingUniRule annotation
    Regioni94 – 985Adenosylcobalamin bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the methylaspartate mutase GlmS subunit family.UniRule annotation
    Contains 1 B12-binding domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2185.
    KOiK01846.
    OMAiLNGHAYE.
    PhylomeDBiQ9HN21.

    Family and domain databases

    Gene3Di3.40.50.280. 1 hit.
    HAMAPiMF_00526. Me_Asp_mutase_S.
    InterProiIPR006158. Cobalamin-bd.
    IPR006394. Me_Asp_mutase.
    [Graphical view]
    PfamiPF02310. B12-binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF52242. SSF52242. 1 hit.
    TIGRFAMsiTIGR01501. MthylAspMutase. 1 hit.
    PROSITEiPS51332. B12_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HN21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSATDPTVVL GTIGSDAHAV GITLLDHALR EAGFTVHNLG AQTAKTEFAT    50
    AAADHDADAV LVSSLYGHAQ QDCAGLHDQL AAAGVDATTV VGGNLAVGQT 100
    DFETVKQRFE EMGFDRVFSA QTGFEAVVDA VKTELDVDER SPTTTTLGA 149
    Length:149
    Mass (Da):15,390
    Last modified:March 1, 2001 - v1
    Checksum:i25A631D386055E29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG20400.1.
    PIRiD84379.
    RefSeqiNP_280920.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG20400; AAG20400; VNG_2286G.
    GeneIDi1448702.
    KEGGihal:VNG2286G.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG20400.1 .
    PIRi D84379.
    RefSeqi NP_280920.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali Q9HN21.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG2286G.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG20400 ; AAG20400 ; VNG_2286G .
    GeneIDi 1448702.
    KEGGi hal:VNG2286G.

    Phylogenomic databases

    eggNOGi COG2185.
    KOi K01846.
    OMAi LNGHAYE.
    PhylomeDBi Q9HN21.

    Enzyme and pathway databases

    UniPathwayi UPA00561 ; UER00617 .

    Family and domain databases

    Gene3Di 3.40.50.280. 1 hit.
    HAMAPi MF_00526. Me_Asp_mutase_S.
    InterProi IPR006158. Cobalamin-bd.
    IPR006394. Me_Asp_mutase.
    [Graphical view ]
    Pfami PF02310. B12-binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52242. SSF52242. 1 hit.
    TIGRFAMsi TIGR01501. MthylAspMutase. 1 hit.
    PROSITEi PS51332. B12_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.

    Entry informationi

    Entry nameiGMSS_HALSA
    AccessioniPrimary (citable) accession number: Q9HN21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3