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Q9HN14 (HIS4_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

EC=5.3.1.16
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene names
Name:hisA
Ordered Locus Names:VNG_2294G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_01014

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP-Rule MF_01014

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01014.

Sequence similarities

Belongs to the HisA/HisF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2422421-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP-Rule MF_01014
PRO_0000142090

Sites

Active site131Proton acceptor By similarity
Active site1331Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HN14 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: F51938766AE5FFC1

FASTA24224,649
        10         20         30         40         50         60 
MTFESFTVLP AVDMQDGQVV QLVQGERGTE RTYGDPVDAA TDWVAAGAEA LHLVDLDGAF 

        70         80         90        100        110        120 
EGARANATAV EDILDATDVS VQVGGGIRSA EDATALLDRG VDRVILGTAA IETPDIVGEI 

       130        140        150        160        170        180 
AAAYSDGVLV SLDAKDGEVV VEGWTEGTGM DPVAAAQRYA DLGAAGILFT DVDVEGKQEG 

       190        200        210        220        230        240 
VRTDPVRDLV DSVDIPVIAS GGVATVDDVR ALEAAGAAGA VVGTALYEGN FTLADAQAAV 


ED 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG20407.1.
PIRC84380.
RefSeqNP_280927.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HN14.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG2294G.

Proteomic databases

PaxDbQ9HN14.
PRIDEQ9HN14.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG20407; AAG20407; VNG_2294G.
GeneID1448709.
KEGGhal:VNG2294G.

Phylogenomic databases

eggNOGCOG0106.
KOK01814.
OMAYEIGVEN.
PhylomeDBQ9HN14.

Enzyme and pathway databases

UniPathwayUPA00031; UER00009.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01014. HisA.
InterProIPR013785. Aldolase_TIM.
IPR001295. Dihydroorotate_DH_CS.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR00007. TIGR00007. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHIS4_HALSA
AccessionPrimary (citable) accession number: Q9HN14
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways