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Q9HMY8

- GSA_HALSA

UniProt

Q9HMY8 - GSA_HALSA

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
    Short name:
    GSA
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase
    Short name:
    GSA-AT
    Gene namesi
    Name:hemL
    Ordered Locus Names:VNG_2326G
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000120480Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PaxDbiQ9HMY8.

    Interactioni

    Protein-protein interaction databases

    STRINGi64091.VNG2326G.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HMY8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0001.
    KOiK01845.
    OMAiHYPSIDM.
    PhylomeDBiQ9HMY8.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 2 hits.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HMY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRETSRELY DRSLDVLVGG VNSTVRAAPQ PYPTFVQSGD GGHVIDADGN    50
    RYIDWVMGLG PLLLGHDLPQ PVTAAIQRRA SDGPLFGTPT EIEVEHAEFV 100
    ARHVPSVELL RFVNSGTEAT VSAVRLARGY TGRNKIVVMQ GGYHGAQEST 150
    LVEGDADHRG PSSAGIPPAF AQHTIPVPFN DADAVTEVFE THGDDIAAVL 200
    VEPILANKGI VEPVAGYHET LRDLTHDHGA LLIWDEVITG FRVGGLGCAQ 250
    SEFDITPDVT TFGKIIGGGF PVGAIGGRTD VMEEFTPTGD VFQAGTFSGH 300
    PVTMAAGLET LQYAAENDVY EHVNRLGGRL REGLAAVVAE HAPAYTVVGR 350
    DSMFKVVFTR DGDAQSGACT DGCRQDPDCE RHAACPKTGA DVGDAAVQRW 400
    NRVFRPQLLD AGVLLSQNQF ESQFVSYGHT EADVDETIEA YRSAL 445
    Length:445
    Mass (Da):47,619
    Last modified:March 1, 2001 - v1
    Checksum:iC6065E6A729C9C7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG20433.1.
    PIRiE84383.
    RefSeqiNP_280953.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG20433; AAG20433; VNG_2326G.
    GeneIDi1448735.
    KEGGihal:VNG2326G.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG20433.1 .
    PIRi E84383.
    RefSeqi NP_280953.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali Q9HMY8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG2326G.

    Proteomic databases

    PaxDbi Q9HMY8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG20433 ; AAG20433 ; VNG_2326G .
    GeneIDi 1448735.
    KEGGi hal:VNG2326G.

    Phylogenomic databases

    eggNOGi COG0001.
    KOi K01845.
    OMAi HYPSIDM.
    PhylomeDBi Q9HMY8.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 2 hits.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.

    Entry informationi

    Entry nameiGSA_HALSA
    AccessioniPrimary (citable) accession number: Q9HMY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3