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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactori

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:VNG_2326G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000120480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ9HMY8.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2326G.

Structurei

3D structure databases

ProteinModelPortaliQ9HMY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
InParanoidiQ9HMY8.
KOiK01845.
OMAiCTRENIL.
PhylomeDBiQ9HMY8.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 2 hits.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HMY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRETSRELY DRSLDVLVGG VNSTVRAAPQ PYPTFVQSGD GGHVIDADGN
60 70 80 90 100
RYIDWVMGLG PLLLGHDLPQ PVTAAIQRRA SDGPLFGTPT EIEVEHAEFV
110 120 130 140 150
ARHVPSVELL RFVNSGTEAT VSAVRLARGY TGRNKIVVMQ GGYHGAQEST
160 170 180 190 200
LVEGDADHRG PSSAGIPPAF AQHTIPVPFN DADAVTEVFE THGDDIAAVL
210 220 230 240 250
VEPILANKGI VEPVAGYHET LRDLTHDHGA LLIWDEVITG FRVGGLGCAQ
260 270 280 290 300
SEFDITPDVT TFGKIIGGGF PVGAIGGRTD VMEEFTPTGD VFQAGTFSGH
310 320 330 340 350
PVTMAAGLET LQYAAENDVY EHVNRLGGRL REGLAAVVAE HAPAYTVVGR
360 370 380 390 400
DSMFKVVFTR DGDAQSGACT DGCRQDPDCE RHAACPKTGA DVGDAAVQRW
410 420 430 440
NRVFRPQLLD AGVLLSQNQF ESQFVSYGHT EADVDETIEA YRSAL
Length:445
Mass (Da):47,619
Last modified:March 1, 2001 - v1
Checksum:iC6065E6A729C9C7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20433.1.
PIRiE84383.
RefSeqiNP_280953.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20433; AAG20433; VNG_2326G.
GeneIDi1448735.
KEGGihal:VNG2326G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20433.1.
PIRiE84383.
RefSeqiNP_280953.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HMY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG2326G.

Proteomic databases

PaxDbiQ9HMY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG20433; AAG20433; VNG_2326G.
GeneIDi1448735.
KEGGihal:VNG2326G.

Phylogenomic databases

eggNOGiCOG0001.
InParanoidiQ9HMY8.
KOiK01845.
OMAiCTRENIL.
PhylomeDBiQ9HMY8.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 2 hits.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiGSA_HALSA
AccessioniPrimary (citable) accession number: Q9HMY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.