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Q9HMY8

- GSA_HALSA

UniProt

Q9HMY8 - GSA_HALSA

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, VNG_2326G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:VNG_2326G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000120480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PaxDbiQ9HMY8.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2326G.

Structurei

3D structure databases

ProteinModelPortaliQ9HMY8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
KOiK01845.
OMAiHYPSIDM.
PhylomeDBiQ9HMY8.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 2 hits.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HMY8-1 [UniParc]FASTAAdd to Basket

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MNRETSRELY DRSLDVLVGG VNSTVRAAPQ PYPTFVQSGD GGHVIDADGN    50
RYIDWVMGLG PLLLGHDLPQ PVTAAIQRRA SDGPLFGTPT EIEVEHAEFV 100
ARHVPSVELL RFVNSGTEAT VSAVRLARGY TGRNKIVVMQ GGYHGAQEST 150
LVEGDADHRG PSSAGIPPAF AQHTIPVPFN DADAVTEVFE THGDDIAAVL 200
VEPILANKGI VEPVAGYHET LRDLTHDHGA LLIWDEVITG FRVGGLGCAQ 250
SEFDITPDVT TFGKIIGGGF PVGAIGGRTD VMEEFTPTGD VFQAGTFSGH 300
PVTMAAGLET LQYAAENDVY EHVNRLGGRL REGLAAVVAE HAPAYTVVGR 350
DSMFKVVFTR DGDAQSGACT DGCRQDPDCE RHAACPKTGA DVGDAAVQRW 400
NRVFRPQLLD AGVLLSQNQF ESQFVSYGHT EADVDETIEA YRSAL 445
Length:445
Mass (Da):47,619
Last modified:March 1, 2001 - v1
Checksum:iC6065E6A729C9C7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20433.1.
PIRiE84383.
RefSeqiNP_280953.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20433; AAG20433; VNG_2326G.
GeneIDi1448735.
KEGGihal:VNG2326G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20433.1 .
PIRi E84383.
RefSeqi NP_280953.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HMY8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG2326G.

Proteomic databases

PaxDbi Q9HMY8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG20433 ; AAG20433 ; VNG_2326G .
GeneIDi 1448735.
KEGGi hal:VNG2326G.

Phylogenomic databases

eggNOGi COG0001.
KOi K01845.
OMAi HYPSIDM.
PhylomeDBi Q9HMY8.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 2 hits.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiGSA_HALSA
AccessioniPrimary (citable) accession number: Q9HMY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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