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Q9HMV8 (MDH_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Synonyms:mdhA
Ordered Locus Names:VNG_2367G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00487.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentCytoplasm
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Malate dehydrogenase HAMAP-Rule MF_00487
PRO_0000113482

Regions

Nucleotide binding8 – 147NAD By similarity
Nucleotide binding119 – 1213NAD By similarity

Sites

Active site1761Proton acceptor By similarity
Binding site341NAD By similarity
Binding site831Substrate By similarity
Binding site891Substrate By similarity
Binding site961NAD By similarity
Binding site1211Substrate By similarity
Binding site1521Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HMV8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C357C0A9520CC649

FASTA30432,252
        10         20         30         40         50         60 
MTKVSIVGAA GTVGAAAGYN LALRDVVDEL VFVDIPDKEE ETIGQAADAN HGVAYDANTD 

        70         80         90        100        110        120 
VVQGDYADTA GSDVVVITAG IPRQPGQSRT DLAGDNAPIM EDIGSSLAEH NDDFVTVTTS 

       130        140        150        160        170        180 
NPVDLLNRHL YESGDRDRHS VVGFGGRLDS ARFRYVLGQR FDVPVQNVDA TILGEHGDAQ 

       190        200        210        220        230        240 
VPVFSKVRVN GTDPAFSADE REEILADLQE SAMNVIEKKG ATQWGPATGV AHMVEAILND 

       250        260        270        280        290        300 
TGEVLPGSMV LDGEYGLDDV GLGVPVKLGS DGVEEVVEWE LTADERDLLD EAAEKLSAQY 


DEIA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG20463.1.
PIRC84387.
RefSeqNP_280983.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HMV8.
SMRQ9HMV8. Positions 2-304.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG2367G.

Proteomic databases

PaxDbQ9HMV8.
PRIDEQ9HMV8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG20463; AAG20463; VNG_2367G.
GeneID1448764.
KEGGhal:VNG2367G.

Phylogenomic databases

eggNOGCOG0039.
KOK00024.
OMACTADESK.
PhylomeDBQ9HMV8.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_HALSA
AccessionPrimary (citable) accession number: Q9HMV8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families