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Q9HMV8

- MDH_HALSA

UniProt

Q9HMV8 - MDH_HALSA

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADBy similarity
Binding sitei83 – 831SubstrateBy similarity
Binding sitei89 – 891SubstrateBy similarity
Binding sitei96 – 961NADBy similarity
Binding sitei121 – 1211SubstrateBy similarity
Binding sitei152 – 1521SubstrateBy similarity
Active sitei176 – 1761Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 147NADBy similarity
Nucleotide bindingi119 – 1213NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Synonyms:mdhA
Ordered Locus Names:VNG_2367G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Malate dehydrogenasePRO_0000113482Add
BLAST

Proteomic databases

PaxDbiQ9HMV8.
PRIDEiQ9HMV8.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2367G.

Structurei

3D structure databases

ProteinModelPortaliQ9HMV8.
SMRiQ9HMV8. Positions 2-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.Curated

Phylogenomic databases

eggNOGiCOG0039.
InParanoidiQ9HMV8.
KOiK00024.
OMAiCTADESK.
PhylomeDBiQ9HMV8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HMV8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKVSIVGAA GTVGAAAGYN LALRDVVDEL VFVDIPDKEE ETIGQAADAN
60 70 80 90 100
HGVAYDANTD VVQGDYADTA GSDVVVITAG IPRQPGQSRT DLAGDNAPIM
110 120 130 140 150
EDIGSSLAEH NDDFVTVTTS NPVDLLNRHL YESGDRDRHS VVGFGGRLDS
160 170 180 190 200
ARFRYVLGQR FDVPVQNVDA TILGEHGDAQ VPVFSKVRVN GTDPAFSADE
210 220 230 240 250
REEILADLQE SAMNVIEKKG ATQWGPATGV AHMVEAILND TGEVLPGSMV
260 270 280 290 300
LDGEYGLDDV GLGVPVKLGS DGVEEVVEWE LTADERDLLD EAAEKLSAQY

DEIA
Length:304
Mass (Da):32,252
Last modified:March 1, 2001 - v1
Checksum:iC357C0A9520CC649
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20463.1.
PIRiC84387.
RefSeqiNP_280983.1. NC_002607.1.
WP_010903765.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20463; AAG20463; VNG_2367G.
GeneIDi1448764.
KEGGihal:VNG2367G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20463.1 .
PIRi C84387.
RefSeqi NP_280983.1. NC_002607.1.
WP_010903765.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HMV8.
SMRi Q9HMV8. Positions 2-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG2367G.

Proteomic databases

PaxDbi Q9HMV8.
PRIDEi Q9HMV8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG20463 ; AAG20463 ; VNG_2367G .
GeneIDi 1448764.
KEGGi hal:VNG2367G.

Phylogenomic databases

eggNOGi COG0039.
InParanoidi Q9HMV8.
KOi K00024.
OMAi CTADESK.
PhylomeDBi Q9HMV8.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiMDH_HALSA
AccessioniPrimary (citable) accession number: Q9HMV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3