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Protein

Malate dehydrogenase

Gene

mdh

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADBy similarity1
Binding sitei83SubstrateBy similarity1
Binding sitei89SubstrateBy similarity1
Binding sitei96NADBy similarity1
Binding sitei121SubstrateBy similarity1
Binding sitei152SubstrateBy similarity1
Active sitei176Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 14NADBy similarity7
Nucleotide bindingi119 – 121NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseBy similarity (EC:1.1.1.37By similarity)
Gene namesi
Name:mdh
Synonyms:mdhA
Ordered Locus Names:VNG_2367G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134821 – 304Malate dehydrogenaseAdd BLAST304

Proteomic databases

PaxDbiQ9HMV8.
PRIDEiQ9HMV8.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2367G.

Structurei

3D structure databases

ProteinModelPortaliQ9HMV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiarCOG00246. Archaea.
COG0039. LUCA.
InParanoidiQ9HMV8.
KOiK00024.
OMAiNNEHRVL.
PhylomeDBiQ9HMV8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HMV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVSIVGAA GTVGAAAGYN LALRDVVDEL VFVDIPDKEE ETIGQAADAN
60 70 80 90 100
HGVAYDANTD VVQGDYADTA GSDVVVITAG IPRQPGQSRT DLAGDNAPIM
110 120 130 140 150
EDIGSSLAEH NDDFVTVTTS NPVDLLNRHL YESGDRDRHS VVGFGGRLDS
160 170 180 190 200
ARFRYVLGQR FDVPVQNVDA TILGEHGDAQ VPVFSKVRVN GTDPAFSADE
210 220 230 240 250
REEILADLQE SAMNVIEKKG ATQWGPATGV AHMVEAILND TGEVLPGSMV
260 270 280 290 300
LDGEYGLDDV GLGVPVKLGS DGVEEVVEWE LTADERDLLD EAAEKLSAQY

DEIA
Length:304
Mass (Da):32,252
Last modified:March 1, 2001 - v1
Checksum:iC357C0A9520CC649
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20463.1.
PIRiC84387.
RefSeqiWP_010903765.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20463; AAG20463; VNG_2367G.
GeneIDi5953357.
KEGGihal:VNG_2367G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20463.1.
PIRiC84387.
RefSeqiWP_010903765.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HMV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG2367G.

Proteomic databases

PaxDbiQ9HMV8.
PRIDEiQ9HMV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG20463; AAG20463; VNG_2367G.
GeneIDi5953357.
KEGGihal:VNG_2367G.

Phylogenomic databases

eggNOGiarCOG00246. Archaea.
COG0039. LUCA.
InParanoidiQ9HMV8.
KOiK00024.
OMAiNNEHRVL.
PhylomeDBiQ9HMV8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_HALSA
AccessioniPrimary (citable) accession number: Q9HMV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.