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Protein

Malate dehydrogenase

Gene

mdh

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADBy similarity1
Binding sitei83SubstrateBy similarity1
Binding sitei89SubstrateBy similarity1
Binding sitei96NADBy similarity1
Binding sitei121SubstrateBy similarity1
Binding sitei152SubstrateBy similarity1
Active sitei176Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 14NADBy similarity7
Nucleotide bindingi119 – 121NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseBy similarity (EC:1.1.1.37By similarity)
Gene namesi
Name:mdh
Synonyms:mdhA
Ordered Locus Names:VNG_2367G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134821 – 304Malate dehydrogenaseAdd BLAST304

Proteomic databases

PaxDbiQ9HMV8

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2367G

Structurei

3D structure databases

ProteinModelPortaliQ9HMV8
SMRiQ9HMV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiarCOG00246 Archaea
COG0039 LUCA
InParanoidiQ9HMV8
KOiK00024
OMAiRQPGQTR
OrthoDBiPOG093Z062E
PhylomeDBiQ9HMV8

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HMV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVSIVGAA GTVGAAAGYN LALRDVVDEL VFVDIPDKEE ETIGQAADAN
60 70 80 90 100
HGVAYDANTD VVQGDYADTA GSDVVVITAG IPRQPGQSRT DLAGDNAPIM
110 120 130 140 150
EDIGSSLAEH NDDFVTVTTS NPVDLLNRHL YESGDRDRHS VVGFGGRLDS
160 170 180 190 200
ARFRYVLGQR FDVPVQNVDA TILGEHGDAQ VPVFSKVRVN GTDPAFSADE
210 220 230 240 250
REEILADLQE SAMNVIEKKG ATQWGPATGV AHMVEAILND TGEVLPGSMV
260 270 280 290 300
LDGEYGLDDV GLGVPVKLGS DGVEEVVEWE LTADERDLLD EAAEKLSAQY

DEIA
Length:304
Mass (Da):32,252
Last modified:March 1, 2001 - v1
Checksum:iC357C0A9520CC649
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG20463.1
PIRiC84387
RefSeqiWP_010903765.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG20463; AAG20463; VNG_2367G
GeneIDi5953357
KEGGihal:VNG_2367G
PATRICifig|64091.14.peg.1831

Similar proteinsi

Entry informationi

Entry nameiMDH_HALSA
AccessioniPrimary (citable) accession number: Q9HMV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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