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Protein

IMP cyclohydrolase

Gene

purO

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.UniRule annotation

Catalytic activityi

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. IMP cyclohydrolase (purO)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purOUniRule annotation
Ordered Locus Names:VNG_2371C
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001457941 – 194IMP cyclohydrolaseAdd BLAST194

Proteomic databases

PaxDbiQ9HMV4

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2371C

Structurei

3D structure databases

ProteinModelPortaliQ9HMV4
SMRiQ9HMV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal IMP cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04727 Archaea
COG3363 LUCA
InParanoidiQ9HMV4
KOiK11176
OMAiSHVDPIA
OrthoDBiPOG093Z0CY5
PhylomeDBiQ9HMV4

Family and domain databases

Gene3Di3.60.20.20, 1 hit
HAMAPiMF_00705 IMP_cyclohydrol, 1 hit
InterProiView protein in InterPro
IPR010191 IMP_cyclohydrolase
IPR020600 IMP_cyclohydrolase-like
IPR036795 IMP_cyclohydrolase-like_sf
PfamiView protein in Pfam
PF07826 IMP_cyclohyd, 1 hit
PIRSFiPIRSF004866 IMP_cclhdr_arch, 1 hit
SUPFAMiSSF75569 SSF75569, 1 hit
TIGRFAMsiTIGR01922 purO_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HMV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIGRFVVVG PSVAAYRVSS RSFPNRKLIE RPAGLTVVPT ADAEETTNPY
60 70 80 90 100
VSYNCVRTAG GHAVVGNGSH VDPITEKVER GYPPRDALTE ALLAMDYEKD
110 120 130 140 150
DYDTPRIAGV LAPDGTAYVG IVRADAVLVR AVEEPTLVAT YEKDAPEAIG
160 170 180 190
FDAATAADAA REAYSAAFEH AVCAAGVSRR GVGDGYDTAV VNDP
Length:194
Mass (Da):20,480
Last modified:March 1, 2001 - v1
Checksum:iEDFD07EC29BBB328
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG20467.1
PIRiG84387
RefSeqiWP_010903769.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG20467; AAG20467; VNG_2371C
GeneIDi5954394
KEGGihal:VNG_2371C
PATRICifig|64091.14.peg.1835

Similar proteinsi

Entry informationi

Entry nameiPURO_HALSA
AccessioniPrimary (citable) accession number: Q9HMV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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