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Protein

IMP cyclohydrolase

Gene

purO

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.UniRule annotation

Catalytic activityi

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. IMP cyclohydrolase (purO)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purOUniRule annotation
Ordered Locus Names:VNG_2371C
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001457941 – 194IMP cyclohydrolaseAdd BLAST194

Proteomic databases

PaxDbiQ9HMV4.
PRIDEiQ9HMV4.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2371C.

Structurei

3D structure databases

ProteinModelPortaliQ9HMV4.
SMRiQ9HMV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal IMP cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04727. Archaea.
COG3363. LUCA.
InParanoidiQ9HMV4.
KOiK11176.
OMAiYNTPRIA.
OrthoDBiPOG093Z0CY5.
PhylomeDBiQ9HMV4.

Family and domain databases

Gene3Di3.60.20.20. 1 hit.
HAMAPiMF_00705. IMP_cyclohydrol. 1 hit.
InterProiView protein in InterPro
IPR010191. IMP_cyclohydrolase.
IPR020600. IMP_cyclohydrolase-like.
IPR036795. IMP_cyclohydrolase-like_sf.
PfamiView protein in Pfam
PF07826. IMP_cyclohyd. 1 hit.
PIRSFiPIRSF004866. IMP_cclhdr_arch. 1 hit.
SUPFAMiSSF75569. SSF75569. 1 hit.
TIGRFAMsiTIGR01922. purO_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HMV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIGRFVVVG PSVAAYRVSS RSFPNRKLIE RPAGLTVVPT ADAEETTNPY
60 70 80 90 100
VSYNCVRTAG GHAVVGNGSH VDPITEKVER GYPPRDALTE ALLAMDYEKD
110 120 130 140 150
DYDTPRIAGV LAPDGTAYVG IVRADAVLVR AVEEPTLVAT YEKDAPEAIG
160 170 180 190
FDAATAADAA REAYSAAFEH AVCAAGVSRR GVGDGYDTAV VNDP
Length:194
Mass (Da):20,480
Last modified:March 1, 2001 - v1
Checksum:iEDFD07EC29BBB328
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG20467.1.
PIRiG84387.
RefSeqiWP_010903769.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20467; AAG20467; VNG_2371C.
GeneIDi5954394.
KEGGihal:VNG_2371C.
PATRICifig|64091.14.peg.1835.

Similar proteinsi

Entry informationi

Entry nameiPURO_HALSA
AccessioniPrimary (citable) accession number: Q9HMV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families