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Q9HMQ2

- ASSY_HALSA

UniProt

Q9HMQ2 - ASSY_HALSA

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Protein
Argininosuccinate synthase
Gene
argG, VNG_2437G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861Citrulline By similarity
Binding sitei116 – 1161ATP; via amide nitrogen By similarity
Binding sitei118 – 1181Aspartate By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei122 – 1221Citrulline By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei172 – 1721Citrulline By similarity
Binding sitei181 – 1811Citrulline By similarity
Binding sitei254 – 2541Citrulline By similarity
Binding sitei266 – 2661Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 179ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:VNG_2437G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Argininosuccinate synthaseUniRule annotation
PRO_0000148673Add
BLAST

Proteomic databases

PaxDbiQ9HMQ2.
PRIDEiQ9HMQ2.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi64091.VNG2437G.

Structurei

3D structure databases

ProteinModelPortaliQ9HMQ2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
KOiK01940.
OMAiRFESTIR.
PhylomeDBiQ9HMQ2.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HMQ2-1 [UniParc]FASTAAdd to Basket

« Hide

MPSGTVALAF SGGLDTTVCV PLLKEEYGYD DVIGVTVDVG QPDAEFAAAR    50
ETAAALGVEH HVVDATAEFA ALCFDAVRAN ATYQGYPLGT ALARPVIADA 100
ILSVAEAEGC AALAHGCTGK GNDQLRFEAV WRASDHDVCA PVRELGLTRE 150
WEIEYAAERD LPVEAGNEGE WSIDTNLWSR SVEGGHLEEP DYQPPADIYA 200
WTDAPSGETG TVDITFEAGV PVAVDGTAME PVALIEALND RAGSYGVGRT 250
DMLEDRMLGL KVRENYEHPA ATTLLAAHKA LEGLVLTKAE RDFTAAVSQQ 300
WAQKAYEGVV EHPLMDALNG YLDETQSAVS GTVTIAFEGG RARPIARESE 350
HAVYSADAAS FNTETVAGIE QADATGVAKY HGFQSRLANA AFDGNK 396
Length:396
Mass (Da):41,994
Last modified:March 1, 2001 - v1
Checksum:i8DA8C2DCAD94D092
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20519.1.
PIRiC84394.
RefSeqiNP_281039.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20519; AAG20519; VNG_2437G.
GeneIDi1448820.
KEGGihal:VNG2437G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20519.1 .
PIRi C84394.
RefSeqi NP_281039.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HMQ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG2437G.

Proteomic databases

PaxDbi Q9HMQ2.
PRIDEi Q9HMQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG20519 ; AAG20519 ; VNG_2437G .
GeneIDi 1448820.
KEGGi hal:VNG2437G.

Phylogenomic databases

eggNOGi COG0137.
KOi K01940.
OMAi RFESTIR.
PhylomeDBi Q9HMQ2.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiASSY_HALSA
AccessioniPrimary (citable) accession number: Q9HMQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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