Reviewed,
UniProtKB/Swiss-Prot Q9HMH9 (PYRC_HALSA)
Last modified
June 16, 2009.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Dihydroorotase Short name=DHOase EC=3.5.2.3 | ||||
| Gene names |
| ||||
| Organism | Halobacterium salinarium (Halobacterium halobium) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 2242 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium |
Protein attributes
| Sequence length | 422 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00220 |
| Cofactor | Binds 2 zinc ions per subunit By similarity. |
| Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 3/6. HAMAP MF_00220 |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the DHOase family. Type 2 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Molecular function | dihydroorotase activity Inferred from electronic annotation. Source: HAMAP zinc ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 422 | 422 | Dihydroorotase HAMAP MF_00220 | PRO_0000147268 | |||||
Sites | |||||||||
| Metal binding | 53 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 55 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 172 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 223 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 291 | 1 | Zinc 1 By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of Halobacterium species NRC-1." Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. DasSarma S.Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed: 11016950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700922 / JCM 11081 / NRC-1. |
Cross-references
Sequence databases | |
|---|---|
| AE004437 Genomic DNA. Translation: AAG20592.1. | |
| PIR | D84403. |
| RefSeq | NP_281112.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GKR based on UniProtKB P81006. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1448897. |
| GenomeReviews | Gene locus VNG_2533G in contig AE004437_GR. |
| KEGG | hal:VNG2533G. |
| NMPDR | fig|64091.1.peg.2139. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q9HMH9. |
| OMA | Q9HMH9. HSKAGWT. |
Enzyme and pathway databases | |
| BioCyc | HSP64091:VNG2533G-MON. |
| BRENDA | 3.5.2.3. 141893. |
Family and domain databases | |
| HAMAP | MF_00220. [Tree] |
| InterPro | IPR006680. Amidohydro_1. IPR004722. DHOmult. IPR002195. Dihydroorotase_CS. [Graphical view] |
| Pfam | PF01979. Amidohydro_1. 1 hit. [Graphical view] |
| ProDom | PD000518. DHOase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00857. pyrC_multi. 1 hit. |
| PROSITE | PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRC_HALSA | ||||||||
| Accession | Primary (citable) accession number: Q9HMH9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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