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Q9HMH9 (PYRC_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase

Short name=DHOase
EC=3.5.2.3
Gene names
Name:pyrC
Ordered Locus Names:VNG_2533G
OrganismHalobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00220_A

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00220_A

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00220_A

Subunit structure

Homodimer By similarity. HAMAP MF_00220_A

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiondihydroorotase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Dihydroorotase HAMAP MF_00220_A
PRO_0000147268

Sites

Metal binding531Zinc 1 By similarity
Metal binding551Zinc 1 By similarity
Metal binding1721Zinc 2 By similarity
Metal binding2231Zinc 2 By similarity
Metal binding2911Zinc 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HMH9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C055ADECC6E34125

FASTA42244,817
        10         20         30         40         50         60 
MRVIRDAVLA DGRVRDIRLD GERIDAVGTA LDGELFVDAN ADYRVLPGMI DAHVHFRQPG 

        70         80         90        100        110        120 
FEHKETWASG SRSAAAGGVT TVVDQPNTAP PTVTGDAVDE KAAHAAADSV VDWGVNGGVT 

       130        140        150        160        170        180 
GEWDPASLFD RSLFALGEVF LADSTGDMGI DAALFRDACQ RAASEDVVVT VHAEDADRFD 

       190        200        210        220        230        240 
TAAKSRSDAD AWSAYRTPEA EAAAVERAVE VGTEAGATIH IAHTSTPEGV DAAAAGGATC 

       250        260        270        280        290        300 
EATPHHLFLS RDDLDDLGTF GRMNPPLRSD PRREALFERL ADGRIDVVAT DHAPHTRAEK 

       310        320        330        340        350        360 
AADIWDAPSG VPGVETALPL LLGAAHRGEL SYERVRDVTA ANPADVFGLE RKGHIAAGRD 

       370        380        390        400        410        420 
ADLVLVDPDD AREIHGDDLH SNCEWTPFEG HVGVFPAMTL VRGTTVWDGD TVSAFDGRNV 


RQ 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG20592.1.
PIRD84403.
RefSeqNP_281112.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HMH9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1448897.
GenomeReviewsGene locus VNG_2533G in contig AE004437_GR.
KEGGhal:VNG2533G.
NMPDRfig|64091.1.peg.2139.

Phylogenomic databases

HOGENOMHBG724623.
OMAGKFNPPL.
PhylomeDBQ9HMH9.
ProtClustDBPRK02382.

Enzyme and pathway databases

BioCycHSP64091:VNG2533G-MONOMER.

Family and domain databases

HAMAPMF_00220_A. PyrC_type2_A.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00857. PyrC_multi. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRC_HALSA
AccessionPrimary (citable) accession number: Q9HMH9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 1, 2001
Last modified: December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families