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Q9HMF3

- DUT_HALSA

UniProt

Q9HMF3 - DUT_HALSA

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Protein
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
dut, VNG_2570G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:dut
Ordered Locus Names:VNG_2570G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation
PRO_0000153636Add
BLAST

Proteomic databases

PaxDbiQ9HMF3.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2570G.

Structurei

3D structure databases

ProteinModelPortaliQ9HMF3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0717.
KOiK01520.
OMAiWDAGYEG.
PhylomeDBiQ9HMF3.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00635. dUTPase_arch.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HMF3-1 [UniParc]FASTAAdd to Basket

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MYERGAFVAD HVEPVADDQI QPNGVDLTVD AVLEQTEPGR IDTDGKTIGD    50
RSPVTPTADE DSTDTTVTIQ PGTYILQYAE TITIPENHVG FVYPRSSLMR 100
NSCMLHSAVW DAGYTGRGEG LFEVHHEITI ARGARVAQLV LATGDHENTY 150
DGSYQHERTD TRPGE 165
Length:165
Mass (Da):18,118
Last modified:March 1, 2001 - v1
Checksum:iAA5039B5964D4F77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20618.1.
PIRiF84406.
RefSeqiNP_281138.1. NC_002607.1.
WP_010903920.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20618; AAG20618; VNG_2570G.
GeneIDi1448925.
KEGGihal:VNG2570G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG20618.1 .
PIRi F84406.
RefSeqi NP_281138.1. NC_002607.1.
WP_010903920.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HMF3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 64091.VNG2570G.

Proteomic databases

PaxDbi Q9HMF3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG20618 ; AAG20618 ; VNG_2570G .
GeneIDi 1448925.
KEGGi hal:VNG2570G.

Phylogenomic databases

eggNOGi COG0717.
KOi K01520.
OMAi WDAGYEG.
PhylomeDBi Q9HMF3.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00635. dUTPase_arch.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiDUT_HALSA
AccessioniPrimary (citable) accession number: Q9HMF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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