Q9HM61 (VATI_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type ATP synthase subunit I

Alternative name(s):
V-ATPase subunit I

Gene names

Name:	atpI
Ordered Locus Names:	Ta0008

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the V-ATPase 116 kDa subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting two-sector ATPase complex, proton-transporting domain Inferred from electronic annotation. Source: InterPro
Molecular function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 637	637	V-type ATP synthase subunit I		PRO_0000119236
Regions
	Transmembrane	342 – 362	21	Helical; Potential
	Transmembrane	403 – 423	21	Helical; Potential
	Transmembrane	436 – 456	21	Helical; Potential
	Transmembrane	471 – 491	21	Helical; Potential
	Transmembrane	498 – 518	21	Helical; Potential
	Transmembrane	541 – 561	21	Helical; Potential
	Transmembrane	568 – 588	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9HM61 [UniParc]. Last modified January 24, 2001. Version 1. Checksum: 4B48B1DD7D82486A	FASTA	637	71,573
	10 20 30 40 50 60 MEKIRIIAPY SYRDPVISAL HDLGVMQIEE MREDVDRLLS PAKASEQAKT VMDYLQKFRG 70 80 90 100 110 120 YENILPKRPV RTRAKFTSLA DILNEASKIN IDDDIRIAVN RENDIAAAMK DIDSRLSALE 130 140 150 160 170 180 YMKGYDFDVS IFNGKHFESY IIPDKNVDIK AFSSLNAEIV PLKNAFIITV AEDRTQDLSR 190 200 210 220 230 240 IANSIGARLI HIPDLKGKPD DVIAMLNDER AKLDQAMQEI RKHLGDLSDK YYEKIAQIRE 250 260 270 280 290 300 ALEIEAKKID VEDKLKGTEY TFAVEGWIPS DSFGRVSDAI NRVTGNSCII STVKTNEMPP 310 320 330 340 350 360 TLLRNPRRIS LFEFFIKFYS LPEGTEYDPT LIFALVFPVF FGLMVGDWGY GLAILLISLF 370 380 390 400 410 420 IIHRVDHPPA KSHIPRVISR FVLMIMSPQS LKTLAKALIP SSIVAIIAGL LFNEFFGFAI 430 440 450 460 470 480 LPFTVFHVYA VLPKLMLIAG YIGLGMVVFG FILGFIEDLW MKDVKGAMDR LGWLFFAVGI 490 500 510 520 530 540 ATIGLNLIHH DLTFSVSTGI SNLIAVALIV IGIPLIAIKE KSQGFIEMPS IISHILSYLR 550 560 570 580 590 600 LVGILIASVV IAEIIDLVFM KSIVSHSIGL AIAGVVILIF GQMFNLILAV FEPGIQGARL 610 620 630 IYVEFFSKFY HGNGRMFRPF RSQRKYTEDG LDFDKAR

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445063 Genomic DNA. Translation: CAC11157.1.
RefSeq	NP_393486.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HM61.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1455679.
GenomeReviews	Gene locus Ta0008 in contig AL139299_GR.
KEGG	tac:Ta0008.
NMPDR	fig|273075.1.peg.8.
Phylogenomic databases
HOGENOM	HBG245400.
OMA	FINLQDE.
ProtClustDB	PRK05771.
Enzyme and pathway databases
BioCyc	TACI273075:TA0008-MONOMER.
Family and domain databases
InterPro	IPR002490. ATPase_V0/A0-cplx_116kDa_su. [Graphical view]
KO	K02123.
Pfam	PF01496. V_ATPase_I. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VATI_THEAC

Accession

Primary (citable) accession number: Q9HM61

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	January 24, 2001
Last modified:	November 16, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program