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Q9HM55

- OGG1_THEAC

UniProt

Q9HM55 - OGG1_THEAC

Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (10 Oct 2002)
      Previous versions | rss
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    • Comment

    Functioni

    Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

    Catalytic activityi

    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291UniRule annotation

    GO - Molecular functioni

    1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
    2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase, Lyase

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-glycosylase/DNA lyaseUniRule annotation
    Including the following 2 domains:
    8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
    DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
    Short name:
    AP lyaseUniRule annotation
    Gene namesi
    Name:oggUniRule annotation
    Ordered Locus Names:Ta0014
    OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
    Taxonomic identifieri273075 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001024: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Probable N-glycosylase/DNA lyasePRO_0000159568Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273075.Ta0014m.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HM55.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type-2 OGG1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1059.
    KOiK03653.
    OMAiLDLYLWY.

    Family and domain databases

    HAMAPiMF_00241. Ogg.
    InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view]
    PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
    SMARTiSM00478. ENDO3c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HM55-1 [UniParc]FASTAAdd to Basket

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    MDSLISIPFL NDESVRSTIY RKVEEFRSIG KSSKEVLFKE LVFCILAANT    50
    SASMSLRMQE SIGDGFLYLS RDDLRKALKE NKYRFYNVRS DFIVKSRNII 100
    DDLPALVASP DHEGSRDYLV ENVYGIGYKE ASHFLRNVGI FDFAILDKHI 150
    MKWMAQYYPV KKNTSRKNYL YNEEIFRNIS AGFGIEPGIL DLFIWYEETG 200
    TVIK 204
    Length:204
    Mass (Da):23,690
    Last modified:October 10, 2002 - v2
    Checksum:iB66235138976AE20
    GO

    Sequence cautioni

    The sequence CAC11163.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445063 Genomic DNA. Translation: CAC11163.1. Different initiation.
    RefSeqiNP_393492.1. NC_002578.1.

    Genome annotation databases

    EnsemblBacteriaiCAC11163; CAC11163; CAC11163.
    GeneIDi1456957.
    KEGGitac:Ta0014m.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445063 Genomic DNA. Translation: CAC11163.1 . Different initiation.
    RefSeqi NP_393492.1. NC_002578.1.

    3D structure databases

    ProteinModelPortali Q9HM55.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273075.Ta0014m.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC11163 ; CAC11163 ; CAC11163 .
    GeneIDi 1456957.
    KEGGi tac:Ta0014m.

    Phylogenomic databases

    eggNOGi COG1059.
    KOi K03653.
    OMAi LDLYLWY.

    Family and domain databases

    HAMAPi MF_00241. Ogg.
    InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view ]
    PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
    SMARTi SM00478. ENDO3c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
      Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
      Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

    Entry informationi

    Entry nameiOGG1_THEAC
    AccessioniPrimary (citable) accession number: Q9HM55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: October 10, 2002
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3