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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciTACI273075:G1GT7-15-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyaseUniRule annotation
Including the following 2 domains:
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Name:oggUniRule annotation
Ordered Locus Names:Ta0014
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595681 – 204Probable N-glycosylase/DNA lyaseAdd BLAST204

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0014m

Structurei

3D structure databases

ProteinModelPortaliQ9HM55
SMRiQ9HM55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04357 Archaea
COG1059 LUCA
KOiK03653
OMAiGYKEASH
OrthoDBiPOG093Z0AOL

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
Gene3Di1.10.1670.10, 2 hits
HAMAPiMF_00241 Ogg, 1 hit
InterProiView protein in InterPro
IPR012092 DNA_glyclase/DNA_lyase_thermo
IPR011257 DNA_glycosylase
IPR003265 HhH-GPD_domain
IPR023170 HTH_base_excis_C
PIRSFiPIRSF005954 Thrmst_ogg, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HM55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSLISIPFL NDESVRSTIY RKVEEFRSIG KSSKEVLFKE LVFCILAANT
60 70 80 90 100
SASMSLRMQE SIGDGFLYLS RDDLRKALKE NKYRFYNVRS DFIVKSRNII
110 120 130 140 150
DDLPALVASP DHEGSRDYLV ENVYGIGYKE ASHFLRNVGI FDFAILDKHI
160 170 180 190 200
MKWMAQYYPV KKNTSRKNYL YNEEIFRNIS AGFGIEPGIL DLFIWYEETG

TVIK
Length:204
Mass (Da):23,690
Last modified:October 10, 2002 - v2
Checksum:iB66235138976AE20
GO

Sequence cautioni

The sequence CAC11163 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445063 Genomic DNA Translation: CAC11163.1 Different initiation.
RefSeqiWP_010900441.1, NC_002578.1

Genome annotation databases

EnsemblBacteriaiCAC11163; CAC11163; CAC11163
GeneIDi1456957
KEGGitac:Ta0014

Similar proteinsi

Entry informationi

Entry nameiOGG1_THEAC
AccessioniPrimary (citable) accession number: Q9HM55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: May 23, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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