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Protein

ATP-dependent DNA helicase Ta0057

Gene

Ta0057

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Cofactori

[4Fe-4S] clusterNote: Binds 1 [4Fe-4S] cluster.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi74Iron-sulfur (4Fe-4S)1
Metal bindingi95Iron-sulfur (4Fe-4S)1
Metal bindingi110Iron-sulfur (4Fe-4S)1
Metal bindingi146Iron-sulfur (4Fe-4S)1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

4Fe-4S, ATP-binding, DNA-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent DNA helicase Ta0057 (EC:3.6.4.12)
Gene namesi
Ordered Locus Names:Ta0057
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003523101 – 602ATP-dependent DNA helicase Ta0057Add BLAST602

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0057m.

Structurei

Secondary structure

1602
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 10Combined sources7
Beta strandi13 – 16Combined sources4
Helixi17 – 32Combined sources16
Beta strandi35 – 42Combined sources8
Helixi43 – 59Combined sources17
Beta strandi64 – 66Combined sources3
Helixi70 – 73Combined sources4
Helixi77 – 80Combined sources4
Helixi88 – 103Combined sources16
Helixi107 – 109Combined sources3
Helixi115 – 118Combined sources4
Helixi120 – 129Combined sources10
Helixi133 – 142Combined sources10
Helixi147 – 154Combined sources8
Helixi155 – 157Combined sources3
Beta strandi159 – 164Combined sources6
Helixi165 – 168Combined sources4
Helixi171 – 181Combined sources11
Helixi185 – 187Combined sources3
Beta strandi188 – 192Combined sources5
Helixi195 – 197Combined sources3
Helixi198 – 206Combined sources9
Beta strandi208 – 211Combined sources4
Helixi212 – 224Combined sources13
Beta strandi229 – 231Combined sources3
Helixi236 – 254Combined sources19
Beta strandi256 – 258Combined sources3
Beta strandi260 – 262Combined sources3
Helixi265 – 275Combined sources11
Helixi279 – 302Combined sources24
Helixi310 – 322Combined sources13
Turni326 – 328Combined sources3
Beta strandi329 – 334Combined sources6
Helixi336 – 338Combined sources3
Beta strandi340 – 345Combined sources6
Helixi349 – 352Combined sources4
Helixi353 – 357Combined sources5
Beta strandi358 – 366Combined sources9
Helixi370 – 377Combined sources8
Beta strandi383 – 385Combined sources3
Helixi392 – 394Combined sources3
Beta strandi395 – 400Combined sources6
Helixi407 – 409Combined sources3
Helixi412 – 429Combined sources18
Beta strandi433 – 438Combined sources6
Helixi440 – 446Combined sources7
Helixi464 – 473Combined sources10
Beta strandi479 – 483Combined sources5
Beta strandi489 – 491Combined sources3
Helixi496 – 498Combined sources3
Beta strandi501 – 506Combined sources6
Helixi514 – 527Combined sources14
Helixi530 – 534Combined sources5
Helixi536 – 548Combined sources13
Beta strandi553 – 555Combined sources3
Beta strandi558 – 563Combined sources6
Helixi565 – 573Combined sources9
Beta strandi578 – 581Combined sources4
Helixi583 – 595Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VSFX-ray2.90A1-602[»]
4A15X-ray2.20A2-602[»]
5H8WX-ray2.20A1-597[»]
SMRiQ9HM14.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HM14.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 247Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST247
Domaini421 – 602Helicase C-terminalPROSITE-ProRule annotationAdd BLAST182

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi193 – 196DEAH box4

Sequence similaritiesi

Belongs to the helicase family. RAD3/XPD subfamily.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG00770. Archaea.
COG1199. LUCA.
KOiK10844.
OMAiRENYLTI.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR010643. HBB.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF06777. HBB. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiPS51193. HELICASE_ATP_BIND_2. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HM14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKSYGVALE SPTGSGKTIM ALKSALQYSS ERKLKVLYLV RTNSQEEQVI
60 70 80 90 100
KELRSLSSTM KIRAIPMQGR VNMCILYRMV DDLHEINAES LAKFCNMKKR
110 120 130 140 150
EVMAGNEAAC PYFNFKIRSD ETKRFLFDEL PTAEEFYDYG ERNNVCPYES
160 170 180 190 200
MKAALPDADI VIAPYAYFLN RSVAEKFLSH WGVSRNQIVI ILDEAHNLPD
210 220 230 240 250
IGRSIGSFRI SVESLNRADR EAQAYGDPEL SQKIHVSDLI EMIRSALQSM
260 270 280 290 300
VSERCGKGDV RIRFQEFMEY MRIMNKRSER EIRSLLNYLY LFGEYVENEK
310 320 330 340 350
EKVGKVPFSY CSSVASRIIA FSDQDEEKYA AILSPEDGGY MQAACLDPSG
360 370 380 390 400
ILEVLKESKT IHMSGTLDPF DFYSDITGFE IPFKKIGEIF PPENRYIAYY
410 420 430 440 450
DGVSSKYDTL DEKELDRMAT VIEDIILKVK KNTIVYFPSY SLMDRVENRV
460 470 480 490 500
SFEHMKEYRG IDQKELYSML KKFRRDHGTI FAVSGGRLSE GINFPGNELE
510 520 530 540 550
MIILAGLPFP RPDAINRSLF DYYERKYGKG WEYSVVYPTA IKIRQEIGRL
560 570 580 590 600
IRSAEDTGAC VILDKRAGQF RKFIPDMKKT SDPASDIYNF FISAQAREKY

GA
Length:602
Mass (Da):69,169
Last modified:March 1, 2001 - v1
Checksum:iCE13FA7D1F3A0DD8
GO

Sequence cautioni

The sequence CAC11205 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445063 Genomic DNA. Translation: CAC11205.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiCAC11205; CAC11205; CAC11205.
KEGGitac:Ta0057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445063 Genomic DNA. Translation: CAC11205.1. Different initiation.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VSFX-ray2.90A1-602[»]
4A15X-ray2.20A2-602[»]
5H8WX-ray2.20A1-597[»]
SMRiQ9HM14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta0057m.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC11205; CAC11205; CAC11205.
KEGGitac:Ta0057.

Phylogenomic databases

eggNOGiarCOG00770. Archaea.
COG1199. LUCA.
KOiK10844.
OMAiRENYLTI.

Miscellaneous databases

EvolutionaryTraceiQ9HM14.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR010643. HBB.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF06777. HBB. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiPS51193. HELICASE_ATP_BIND_2. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXPD_THEAC
AccessioniPrimary (citable) accession number: Q9HM14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.