Q9HLY3 (PUR5_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	Ta0090

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_A
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_A
Subcellular location	Cytoplasm By similarity HAMAP MF_00741_A.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_A		PRO_0000148291

Sequences

	Sequence		Length	Mass (Da)
	Q9HLY3 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: D921C013CDFD97C2	FASTA	338	36,992
	10 20 30 40 50 60 MSEVEGGIIN RKLQGEFVNT FIRQLKFHRE DFKNIGYIGG FTSIIDMGNF GITFNNDGVG 70 80 90 100 110 120 TKAMIAEAVN KYDTLGIDCV AMNVNDAITV GSEPIAMVDY LAVNKMDEEM AKQLGTGFNV 130 140 150 160 170 180 GAQMANISIV GGETAVLPDV VKHIDISGAV IGIVQKNQII TGSNIKEGDV IIGLGSSGLH 190 200 210 220 230 240 SNGFTTVRKI IADNNLDLQD TFPGDSKKTY EVLLEPTRIY VREILDIMGI ITIKGMANIT 250 260 270 280 290 300 GGGFKNITRM KDMKYVIDDP FEPQNVFIRL MEMGNLNYAQ MFEIFNMGTG FVLVIDEDEK 310 320 330 VDIMNALKGK VPVKVMGHVE NGSGVEIPKY EVSLKGYY

References

[1]	"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445063 Genomic DNA. Translation: CAC11238.1.
RefSeq	NP_393568.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HLY3.
ModBase	Search...
Proteomic databases
PRIDE	Q9HLY3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1455747.
GenomeReviews	Gene locus Ta0090 in contig AL139299_GR.
KEGG	tac:Ta0090.
NMPDR	fig|273075.1.peg.90.
Phylogenomic databases
HOGENOM	HBG531222.
OMA	GIDMIAM.
PhylomeDB	Q9HLY3.
ProtClustDB	PRK05385.
Enzyme and pathway databases
BioCyc	TACI273075:TA0090-MONOMER.
Family and domain databases
HAMAP	MF_00741_A. AIRS_A. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_THEAC

Accession

Primary (citable) accession number: Q9HLY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program