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Q9HLX5 (SYH_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase
EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:Ta0099
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP MF_00127

Subcellular location

Cytoplasm HAMAP MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Histidine--tRNA ligase HAMAP MF_00127
PRO_0000136328

Secondary structure

1 ................................................................... 426
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9HLX5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 45610EC7EE055B96

FASTA42648,229
        10         20         30         40         50         60 
MYRLQIEKIR GFRDFYPEDM DVEKFIFKTA EEAAEAFGFR RIDFPSLEYL DLYRIKSGEE 

        70         80         90        100        110        120 
LLQQTYSFVD KGGREVTLIP EATPSTVRMV TSRKDLQRPL RWYSFPKVWR YEEPQAGRYR 

       130        140        150        160        170        180 
EHYQFNADIF GSDSPEADAE VIALASSILD RLGLQDIYEI RINSRKIMEE IIGGMTSSDP 

       190        200        210        220        230        240 
FSVFSIIDRY HKISREEFVD QLRSAGIGED GVSMIADLCS GTRGIDEMAR ITGKSSEEIA 

       250        260        270        280        290        300 
RMAAVEDLLA SYGVKNVRYD FSIVRGLSYY TGIVFEAYDR SGQFRAILGG GRYDNLASLM 

       310        320        330        340        350        360 
SGESVPAVGF GMGDAVISLL LKRENVQIPR EKKSVYICRV GKINSSIMNE YSRKLRERGM 

       370        380        390        400        410        420 
NVTVEIMERG LSAQLKYASA IGADFAVIFG ERDLERGVVT IRNMYTGSQE NVGLDSVVEH 


LISQAT

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References

[1]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed: 11029001] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL445063 Genomic DNA. Translation: CAC11247.1.
RefSeqNP_393577.1. NC_002578.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WU7X-ray2.40A/B1-426[»]
ProteinModelPortalQ9HLX5.
SMRQ9HLX5. Positions 3-426.
ModBaseSearch...

Proteomic databases

PRIDEQ9HLX5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1455755.
GenomeReviewsGene locus Ta0099 in contig AL139299_GR.
KEGGtac:Ta0099.
NMPDRfig|273075.1.peg.99.

Phylogenomic databases

HOGENOMHBG616575.
OMAFAYGFDR.
PhylomeDBQ9HLX5.
ProtClustDBPRK00037.

Enzyme and pathway databases

BioCycTACI273075:TA0099-MONOMER.

Family and domain databases

HAMAPMF_00127. His_tRNA_synth.
[Tree]
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-synth_IIa_subgr.
IPR004516. His-tRNA_synth_IIA.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
KOK01892.
PANTHERPTHR11476. His-tRNA_synth. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. Anticodon_bd. 1 hit.
TIGRFAMsTIGR00442. HisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_THEAC
AccessionPrimary (citable) accession number: Q9HLX5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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