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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:hisS
Ordered Locus Names:Ta0099
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Histidine--tRNA ligasePRO_0000136328Add
BLAST

Proteomic databases

PRIDEiQ9HLX5.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0099.

Structurei

Secondary structure

1
426
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 3620Combined sources
Beta strandi46 – 494Combined sources
Helixi51 – 544Combined sources
Helixi61 – 644Combined sources
Beta strandi67 – 693Combined sources
Beta strandi75 – 784Combined sources
Helixi83 – 908Combined sources
Beta strandi98 – 1047Combined sources
Beta strandi107 – 1093Combined sources
Beta strandi120 – 13112Combined sources
Helixi135 – 15117Combined sources
Turni152 – 1565Combined sources
Beta strandi157 – 1648Combined sources
Helixi165 – 1739Combined sources
Helixi180 – 1889Combined sources
Turni189 – 1924Combined sources
Helixi195 – 20410Combined sources
Helixi209 – 22012Combined sources
Helixi225 – 2317Combined sources
Helixi237 – 25115Combined sources
Turni265 – 2695Combined sources
Beta strandi271 – 2799Combined sources
Beta strandi287 – 2926Combined sources
Helixi296 – 3016Combined sources
Beta strandi307 – 3137Combined sources
Helixi314 – 32310Combined sources
Beta strandi334 – 3429Combined sources
Helixi345 – 35612Combined sources
Turni357 – 3593Combined sources
Beta strandi361 – 3644Combined sources
Helixi371 – 38010Combined sources
Beta strandi384 – 3907Combined sources
Helixi391 – 3955Combined sources
Beta strandi398 – 4036Combined sources
Turni404 – 4063Combined sources
Beta strandi409 – 4135Combined sources
Helixi414 – 4163Combined sources
Helixi417 – 4237Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WU7X-ray2.40A/B1-426[»]
ProteinModelPortaliQ9HLX5.
SMRiQ9HLX5. Positions 3-426.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HLX5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00404. Archaea.
COG0124. LUCA.
HOGENOMiHOG000018073.
KOiK01892.
OMAiCGGGNFK.

Family and domain databases

CDDicd00859. HisRS_anticodon. 1 hit.
Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth. 1 hit.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR033656. HisRS_anticodon.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HLX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRLQIEKIR GFRDFYPEDM DVEKFIFKTA EEAAEAFGFR RIDFPSLEYL
60 70 80 90 100
DLYRIKSGEE LLQQTYSFVD KGGREVTLIP EATPSTVRMV TSRKDLQRPL
110 120 130 140 150
RWYSFPKVWR YEEPQAGRYR EHYQFNADIF GSDSPEADAE VIALASSILD
160 170 180 190 200
RLGLQDIYEI RINSRKIMEE IIGGMTSSDP FSVFSIIDRY HKISREEFVD
210 220 230 240 250
QLRSAGIGED GVSMIADLCS GTRGIDEMAR ITGKSSEEIA RMAAVEDLLA
260 270 280 290 300
SYGVKNVRYD FSIVRGLSYY TGIVFEAYDR SGQFRAILGG GRYDNLASLM
310 320 330 340 350
SGESVPAVGF GMGDAVISLL LKRENVQIPR EKKSVYICRV GKINSSIMNE
360 370 380 390 400
YSRKLRERGM NVTVEIMERG LSAQLKYASA IGADFAVIFG ERDLERGVVT
410 420
IRNMYTGSQE NVGLDSVVEH LISQAT
Length:426
Mass (Da):48,229
Last modified:March 1, 2001 - v1
Checksum:i45610EC7EE055B96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445063 Genomic DNA. Translation: CAC11247.1.
RefSeqiWP_010900526.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11247; CAC11247; CAC11247.
GeneIDi1455755.
KEGGitac:Ta0099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445063 Genomic DNA. Translation: CAC11247.1.
RefSeqiWP_010900526.1. NC_002578.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WU7X-ray2.40A/B1-426[»]
ProteinModelPortaliQ9HLX5.
SMRiQ9HLX5. Positions 3-426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta0099.

Proteomic databases

PRIDEiQ9HLX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC11247; CAC11247; CAC11247.
GeneIDi1455755.
KEGGitac:Ta0099.

Phylogenomic databases

eggNOGiarCOG00404. Archaea.
COG0124. LUCA.
HOGENOMiHOG000018073.
KOiK01892.
OMAiCGGGNFK.

Miscellaneous databases

EvolutionaryTraceiQ9HLX5.

Family and domain databases

CDDicd00859. HisRS_anticodon. 1 hit.
Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth. 1 hit.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR033656. HisRS_anticodon.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYH_THEAC
AccessioniPrimary (citable) accession number: Q9HLX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.