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Q9HLV2

- PCKG_THEAC

UniProt

Q9HLV2 - PCKG_THEAC

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (26 Sep 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei75 – 751SubstrateUniRule annotation
    Binding sitei209 – 2091Substrate; via amide nitrogenUniRule annotation
    Metal bindingi216 – 2161ManganeseUniRule annotation
    Binding sitei216 – 2161SubstrateUniRule annotation
    Metal bindingi236 – 2361Manganese; via tele nitrogenUniRule annotation
    Binding sitei258 – 2581SubstrateUniRule annotation
    Active sitei260 – 2601UniRule annotation
    Metal bindingi287 – 2871ManganeseUniRule annotation
    Binding sitei376 – 3761GTPUniRule annotation
    Binding sitei407 – 4071GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi259 – 2646GTPUniRule annotation
    Nucleotide bindingi500 – 5034GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:Ta0123
    OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
    Taxonomic identifieri273075 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001024: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 588588Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103624Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273075.Ta0123.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HLV2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni374 – 3763Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiWDNPAGV.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HLV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAIDESELN QHAMKWIEGI KKFTEAEDVV VCDGTPEEFK QISNELIKSG    50
    EFIKLNENRY PNSFLYRSDR TDVARSEERT FIAAPDASMA GSLNNHMTLQ 100
    QVSEVWNKFF RGAYRGKTMF VIPYALGPLN SRFTDYGIEI TDSRYVVLNL 150
    HYITRMGKQV IGSMPEKFVK GVHATGTLDP GNKFIIHIPW DKPEGVDADI 200
    LSVNTNYGGN ALLSKKCHAL RIASVRARKE GWLAEHMLLL EVEDPHGRKV 250
    YITGAFPSAS GKTNLAMINP PKQYAEAGWK TRLLSDDIAW MKMKDGMLYA 300
    TNPENGFFAV VPGTNYRTNK NAMITLSRNT IFTNTGMTKT GEPWWEGLDP 350
    LQEELYDWKG VLRKPDGEPI AHPNSRFTSP LSNYPFLSDR SEDPEGVPVS 400
    AILFGGRRAS LVPLVYEAFN WNHGVFMGAT MGVEKTAASE GKVGELRRDP 450
    MAMRPFCGYN ISDYFRHWIE MGRKLSRRPK IFYVNWFRRR QDGSFIWPGF 500
    SENFRVIEWI LYRLDHNDNA IETPIGYIPE NINTDGLNLT KQDMEELFRI 550
    DRDGWREEMK SIGDYFSQIG NIPEDLLIEF EMEKRRIS 588
    Length:588
    Mass (Da):67,308
    Last modified:September 26, 2001 - v2
    Checksum:i30E963E7E62D78C1
    GO

    Sequence cautioni

    The sequence CAC11270.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445063 Genomic DNA. Translation: CAC11270.1. Different initiation.
    RefSeqiNP_393601.1. NC_002578.1.

    Genome annotation databases

    EnsemblBacteriaiCAC11270; CAC11270; CAC11270.
    GeneIDi1455774.
    KEGGitac:Ta0123.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445063 Genomic DNA. Translation: CAC11270.1 . Different initiation.
    RefSeqi NP_393601.1. NC_002578.1.

    3D structure databases

    ProteinModelPortali Q9HLV2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273075.Ta0123.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC11270 ; CAC11270 ; CAC11270 .
    GeneIDi 1455774.
    KEGGi tac:Ta0123.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi WDNPAGV.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
      Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
      Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

    Entry informationi

    Entry nameiPCKG_THEAC
    AccessioniPrimary (citable) accession number: Q9HLV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: September 26, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3