Q9HLK8 (Q9HLK8_THEAC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Inosine-5'-monophosphate dehydrogenase RuleBase RU003928
EC=1.1.1.205 RuleBase RU003928

Gene names

Ordered Locus Names:

Ta0219

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH. RuleBase RU003928
Pathway	Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. RuleBase RU003928
Sequence similarities	Belongs to the IMPDH/GMPR family. RuleBase RU003927

Ontologies

Keywords
Biological process	GMP biosynthesis RuleBase RU003928 Purine biosynthesis
Ligand	Metal-binding RuleBase RU003928 NAD RuleBase RU003928 Potassium RuleBase RU003928
Molecular function	Oxidoreductase RuleBase RU003927
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	GMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	IMP dehydrogenase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	302	1	Thioimidate intermediate By similarity PIRSR PIRSR000130-1

Sequences

	Sequence		Length	Mass (Da)
	Q9HLK8 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 4450C3DC8FA68673	FASTA	485	52,225
	10 20 30 40 50 60 MYREKFTKIT EGFTFDDVLL IPMRTAVEPK NVVVSSRISR HIQVKVPIVS SPMDTVTEDA 70 80 90 100 110 120 MAIAMARYGA IGVIHRNQPR EKEVEMVKRV KREETIIIRD VYTISPETPI EVARTLMATR 130 140 150 160 170 180 NIAGLPVVKD DKLVGIVTKR DLEFVKKGSS VSDVMVRDVI TAPENVDIDE AIEILHKNRI 190 200 210 220 230 240 EKLPLVDSSG HLVGLITAKD IITRQKFPDA SRDSEGQLMV GAAVGPFDLD RAVEVEKAGA 250 260 270 280 290 300 DFIVVDTAHA DNENVLSSLK KMRKQISVDI VAGNIATAQA AEDLISCDVD GLRVGIGPGS 310 320 330 340 350 360 ICTTRIVAGV GVPQLTAISD VAEAAKDSGI PVIADGGIRY SGDIVKAIAA GADAVMLGSM 370 380 390 400 410 420 LAGTEESPGQ EMIINGRKYK AYRGMGSIGA LTTGLSDRYS KLGNGFIAEG VEGAVPYRGR 430 440 450 460 470 480 VDEVLFQLVG GLRTGMGYVG AATIEDLKRN GKFVRITNNG LRESHPHDIR LISEPPNYQI SNISP

References

[1]	"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445063 Genomic DNA. Translation: CAC11365.1.
RefSeq	NP_393697.1. NC_002578.1.
3D structure databases
HSSP	HSSP built from PDB template 1EEP based on UniProtKB P49058.
ProteinModelPortal	Q9HLK8.
SMR	Q9HLK8. Positions 199-477.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1455855.
GenomeReviews	Gene locus Ta0219 in contig AL139299_GR.
KEGG	tac:Ta0219.
NMPDR	fig|273075.1.peg.219.
Phylogenomic databases
HOGENOM	HBG298985.
OMA	DCAHAHN.
PhylomeDB	Q9HLK8.
ProtClustDB	PRK05567.
Enzyme and pathway databases
BioCyc	TACI273075:TA0219-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR000644. Cysta_beta_synth_core. IPR005990. IMP_DH. IPR018529. IMP_DH-rel. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00088.
PANTHER	PTHR11911:SF6. IMP_DH_GMPRtase. 1 hit.
Pfam	PF00571. CBS. 2 hits. PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF000130. IMPDH. 1 hit.
SMART	SM00116. CBS. 2 hits. [Graphical view]
TIGRFAMs	TIGR01302. IMP_dehydrog. 1 hit.
PROSITE	PS51371. CBS. 2 hits. PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9HLK8_THEAC

Accession

Primary (citable) accession number: Q9HLK8

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)