Q9HLJ0 (HUTI_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable imidazolonepropionase
EC=3.5.2.7

Alternative name(s):
Imidazolone-5-propionate hydrolase

Gene names

Name:	hutI
Ordered Locus Names:	Ta0238

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372
Cofactor	Binds 1 zinc or iron ion per subunit By similarity. HAMAP MF_00372
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372
Subcellular location	Cytoplasm Potential HAMAP MF_00372.
Sequence similarities	Belongs to the HutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Cellular component	Cytoplasm
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Probable imidazolonepropionase HAMAP MF_00372		PRO_0000160979
Sites
	Metal binding	71	1	Zinc or iron By similarity
	Metal binding	73	1	Zinc or iron By similarity
	Metal binding	235	1	Zinc or iron By similarity
	Metal binding	309	1	Zinc or iron By similarity
	Binding site	80	1	Substrate By similarity
	Binding site	93	1	Substrate By similarity
	Binding site	143	1	Substrate By similarity
	Binding site	175	1	Substrate By similarity
	Binding site	238	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HLJ0 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 6F381052AC3A0C01	FASTA	410	45,006
	10 20 30 40 50 60 MRALTNLSQI ATGEGRSFLS GERQADVKVY ENHSILIHGG RIAEITRAVP PGVEEIDCGG 70 80 90 100 110 120 GVAVPGFVDP HTHIAFAGNR VQEFYMRIRG TSYLDILRSG NGIYRTIRDT VNADENRIFK 130 140 150 160 170 180 ETISRVWSAV RRGTTTMEMK TGYGLDQRGE EKILSAIEVI KNTGPISVVP TYLAHVVPQD 190 200 210 220 230 240 VQENAYVEGI LETVKRNRQR ISYADIFCDA GAFSPEASRR FLEAAIAMGI PARIHTNEIE 250 260 270 280 290 300 NVGCVKKTRG LPIVSYDHMI HFDDADLDIV KENGSSVTLL PITVFALNEA YPDARRIIDR 310 320 330 340 350 360 GIPVSIATDI SPLNMNDDMI FAMHLAVRNN HMNAEEVLNA ATINPAASLG LAEKKGTIES 370 380 390 400 410 GKDADLVVLS ARSYDEIPYL YGLDIVSMTI SRGNILYSRG DHGITDTSEA

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445063 Genomic DNA. Translation: CAC11383.1.
RefSeq	NP_393718.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HLJ0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1455872.
GenomeReviews	Gene locus Ta0238 in contig AL139299_GR.
KEGG	tac:Ta0238.
NMPDR	fig|273075.1.peg.240.
Phylogenomic databases
HOGENOM	HBG686142.
OMA	MNMACTL.
PhylomeDB	Q9HLJ0.
ProtClustDB	PRK09356.
Enzyme and pathway databases
BioCyc	TACI273075:TA0238-MONOMER.
Family and domain databases
HAMAP	MF_00372. HutI. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR005920. HutI. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01468.
PANTHER	PTHR22642. PTHR22642. 1 hit.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR01224. HutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_THEAC

Accession

Primary (citable) accession number: Q9HLJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program