ID   SYR_THEAC               Reviewed;         546 AA.
AC   Q9HLE7;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE   AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN   Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=Ta0281;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR   EMBL; AL445063; CAC11426.1; -; Genomic_DNA.
DR   RefSeq; WP_010900710.1; NC_002578.1.
DR   AlphaFoldDB; Q9HLE7; -.
DR   SMR; Q9HLE7; -.
DR   STRING; 273075.gene:9571498; -.
DR   PaxDb; 273075-Ta0281; -.
DR   EnsemblBacteria; CAC11426; CAC11426; CAC11426.
DR   GeneID; 1455910; -.
DR   KEGG; tac:Ta0281; -.
DR   eggNOG; arCOG00487; Archaea.
DR   HOGENOM; CLU_006406_6_1_2; -.
DR   InParanoid; Q9HLE7; -.
DR   OrthoDB; 372102at2157; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   CDD; cd00671; ArgRS_core; 1.
DR   Gene3D; 3.30.1360.70; Arginyl tRNA synthetase N-terminal domain; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   NCBIfam; TIGR00456; argS; 1.
DR   PANTHER; PTHR11956:SF5; ARGININE--TRNA LIGASE, CYTOPLASMIC-RELATED; 1.
DR   PANTHER; PTHR11956; ARGINYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 1.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..546
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_0000151658"
FT   MOTIF           117..127
FT                   /note="'HIGH' region"
SQ   SEQUENCE   546 AA;  63004 MW;  EB72B6D59406E078 CRC64;
     MLLFQDLRKD IYEIVSKRFR ISENDVYLDD TGHSDITIRV FRILKSPDGG ENAVMEIVRS
     ISEKDYVEKA LSEGGYINVW IKRTYMLREV LESIEKSGTY PDVFQEAERV SVEHTSANPT
     GPLHIGRARN SIIGDSIYRI LSRYGYRTVR QYFVNDSGKQ MISLYTAYIK YGGPITIENL
     LENYQKIYRE MEKDQSIEKE IEKNIERYEN ADPEVFGTLR KIAGVMLDGI ASTLKRIGIE
     FDEFDWESDL LLNGSVRKAI DMLETKEEDS ARYIEISGKK VFLTRKDGTT LYFARDIAYH
     LFKAENSEWI IDVLGEDHKD HAKSLNHVLK EMLKLENRVS FMYYSFITLE TGKMSTRRGN
     IVTLQDLVDR TYDEALKIVN EKRPDLSEEE RKKIAEVIAS SAVRYSIIRV SAPKPITFRW
     EEALNFESNS APFIMYSHAR AASILDKAPE PEQSYGMDMP KEEADLVKAM YVYPYYLKDA
     AQDLKPDLIA AYLISLVQKF NDFYGACRVI GTDPLTYARR IRIVKAYKQI LSDAGDLIGI
     KMLDQM
//