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Q9HLE7

- SYR_THEAC

UniProt

Q9HLE7 - SYR_THEAC

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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:Ta0281
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Arginine--tRNA ligasePRO_0000151658Add
BLAST

Proteomic databases

PRIDEiQ9HLE7.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0281.

Structurei

3D structure databases

ProteinModelPortaliQ9HLE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi117 – 12711"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247213.
KOiK01887.
OMAiMEHMGFG.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HLE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLFQDLRKD IYEIVSKRFR ISENDVYLDD TGHSDITIRV FRILKSPDGG
60 70 80 90 100
ENAVMEIVRS ISEKDYVEKA LSEGGYINVW IKRTYMLREV LESIEKSGTY
110 120 130 140 150
PDVFQEAERV SVEHTSANPT GPLHIGRARN SIIGDSIYRI LSRYGYRTVR
160 170 180 190 200
QYFVNDSGKQ MISLYTAYIK YGGPITIENL LENYQKIYRE MEKDQSIEKE
210 220 230 240 250
IEKNIERYEN ADPEVFGTLR KIAGVMLDGI ASTLKRIGIE FDEFDWESDL
260 270 280 290 300
LLNGSVRKAI DMLETKEEDS ARYIEISGKK VFLTRKDGTT LYFARDIAYH
310 320 330 340 350
LFKAENSEWI IDVLGEDHKD HAKSLNHVLK EMLKLENRVS FMYYSFITLE
360 370 380 390 400
TGKMSTRRGN IVTLQDLVDR TYDEALKIVN EKRPDLSEEE RKKIAEVIAS
410 420 430 440 450
SAVRYSIIRV SAPKPITFRW EEALNFESNS APFIMYSHAR AASILDKAPE
460 470 480 490 500
PEQSYGMDMP KEEADLVKAM YVYPYYLKDA AQDLKPDLIA AYLISLVQKF
510 520 530 540
NDFYGACRVI GTDPLTYARR IRIVKAYKQI LSDAGDLIGI KMLDQM
Length:546
Mass (Da):63,004
Last modified:March 1, 2001 - v1
Checksum:iEB72B6D59406E078
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445063 Genomic DNA. Translation: CAC11426.1.
RefSeqiNP_393761.1. NC_002578.1.
WP_010900710.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11426; CAC11426; CAC11426.
GeneIDi1455910.
KEGGitac:Ta0281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445063 Genomic DNA. Translation: CAC11426.1 .
RefSeqi NP_393761.1. NC_002578.1.
WP_010900710.1. NC_002578.1.

3D structure databases

ProteinModelPortali Q9HLE7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273075.Ta0281.

Proteomic databases

PRIDEi Q9HLE7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC11426 ; CAC11426 ; CAC11426 .
GeneIDi 1455910.
KEGGi tac:Ta0281.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247213.
KOi K01887.
OMAi MEHMGFG.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiSYR_THEAC
AccessioniPrimary (citable) accession number: Q9HLE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3