Q9HLE6 (AROA_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Ta0282

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000088339

Sequences

	Sequence		Length	Mass (Da)
	Q9HLE6 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 0EF167698CC2FA26	FASTA	410	45,166
	10 20 30 40 50 60 MTVKIYGSGG SGTVALPSSK SFTQRYILGS VFLNKSVTLN YVTITGDDSI ALDIAQRAGA 70 80 90 100 110 120 NITMNDSSIK IRTSFTCPSD IYVGESATSY RIALGLLGSA GCITHVKGDP DLAKRPMDPL 130 140 150 160 170 180 VKALEANDVH LKLNEDGFYD VDGSESKKRY IEVDGVSSQF VSSMIFYYAR KGGGEFLVKN 190 200 210 220 230 240 MRSPGYVYIT KRVLYDLGYF VNIEKTITIN PSGVWKTAID VEPDYSSLAF FLVLGLLSEN 250 260 270 280 290 300 VDVRFNIKRM SRIQPDSVLL DMFKDNIAID RDTLRVLPGI RDRITVDADH NPDLCPPISV 310 320 330 340 350 360 IGIFSEHGVE IDNYARLKTK ESNRYEGIID MASRFGAIVE DNGKDLFIKR GDLKDPGTLS 370 380 390 400 410 YTDHRMIMSA AVAAAASGFE VEIENETKVS KSFPGFFKEL SKFANVSESN

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445063 Genomic DNA. Translation: CAC11427.1.
RefSeq	NP_393762.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HLE6.
ModBase	Search...
Proteomic databases
PRIDE	Q9HLE6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1455911.
GenomeReviews	Gene locus Ta0282 in contig AL139299_GR.
KEGG	tac:Ta0282.
NMPDR	fig|273075.1.peg.284.
Phylogenomic databases
HOGENOM	HBG245236.
OMA	FANVSES.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	TACI273075:TA0282-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. False negative. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_THEAC

Accession

Primary (citable) accession number: Q9HLE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 1, 2001
Last modified:	November 16, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program