Q9HLE4 (AROE_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Ta0284

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000136068
Regions
	Nucleotide binding	126 – 130	5	NADP By similarity
Sites
	Active site	66	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9HLE4 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 8E2F3268A97F0A79	FASTA	268	30,013
	10 20 30 40 50 60 MNGNSIIGLI GHPVSHSIGQ ILYNRIFQDM GIDAFYLAMD VHMNVLPAFL KNSFFLKAFN 70 80 90 100 110 120 VTIPHKVSII PFLDDLDEIA SQTRSVNLVI REQSRMKGYN TDYYGLDYAL SFNQVEIEEK 130 140 150 160 170 180 RIVIAGSGGI ARTVIRYMLD HGAHRVDVLT RNAQNARRNL DIPGIGLHEN IDEDYDIYVN 190 200 210 220 230 240 CTPLGTLGDG DPFSTVDFRS GRTGIDLVYN PPDTPFLKRM RNAGGRTVSG LDVFIGQGLR 250 260 TLELVFGIRP DSIFREYAVE ALNEIRKG

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445063 Genomic DNA. Translation: CAC11429.1.
RefSeq	NP_393764.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HLE4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1455913.
GenomeReviews	Gene locus Ta0284 in contig AL139299_GR.
KEGG	tac:Ta0284.
NMPDR	fig|273075.1.peg.286.
Phylogenomic databases
HOGENOM	HBG553408.
OMA	FELAKDN.
PhylomeDB	Q9HLE4.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	TACI273075:TA0284-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROE_THEAC

Accession

Primary (citable) accession number: Q9HLE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program