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Q9HLE3 (AROB_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Ta0285
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3603603-dehydroquinate synthase HAMAP MF_00110
PRO_0000140824

Sequences

Sequence LengthMass (Da)Tools
Q9HLE3 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 797B3FD21CE4DF42

FASTA36039,824
        10         20         30         40         50         60 
MDAQRFVLPM NGENISVVIG EDITGHISEE VGHYDSLVFM ISRNVEEMFG SKIPPLENYG 

        70         80         90        100        110        120 
SSTIKITLND GESLKTLRNY QRIIKVLVEK KVSRNSLLVY VGGGTVGDLA GFVAATYKRG 

       130        140        150        160        170        180 
LRMIAVPTTL LAQVDSSIGG KNGLDFSDVK NVIGTFYNPY LIIDDLQFLK STPDLIREGM 

       190        200        210        220        230        240 
GEVIKYSIIA GGDMFRKVSE CSLSNFHDHS ADIVKMSIKI KADIVNRDYY DRNGVRSILN 

       250        260        270        280        290        300 
LGHTIAHGIE GASKGQISHG RAVATGLMVE AHIGEKYGNT RPEVIDEIMK LADNYGIERV 

       310        320        330        340        350        360 
RISDIGVNSI LRYISNDKKM SEGYINMPVP ADIGNIITMK VTERMISDGL NTFIREHERK

« Hide

References

[1]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed: 11029001] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL445063 Genomic DNA. Translation: CAC11430.1.
RefSeqNP_393765.1. NC_002578.1.

3D structure databases

ProteinModelPortalQ9HLE3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1455914.
GenomeReviewsGene locus Ta0285 in contig AL139299_GR.
KEGGtac:Ta0285.
NMPDRfig|273075.1.peg.287.

Phylogenomic databases

HOGENOMHBG632303.
OMATERMISD.
PhylomeDBQ9HLE3.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycTACI273075:TA0285-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_THEAC
AccessionPrimary (citable) accession number: Q9HLE3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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