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Protein

Ferrochelatase

Gene

hemH

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.By similarity

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi167 – 1671IronBy similarity
Metal bindingi239 – 2391IronBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrochelatase (EC:4.99.1.1)
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene namesi
Name:hemH
Ordered Locus Names:Ta0311
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308FerrochelatasePRO_0000175237Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0311.

Structurei

3D structure databases

ProteinModelPortaliQ9HLB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.Curated

Phylogenomic databases

eggNOGiarCOG05373. Archaea.
COG0276. LUCA.
HOGENOMiHOG000112886.
KOiK01772.
OMAiNNIFTEY.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HLB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSALLLLSY GSPERIEDLD EYLKNIFNGK PVPESVREEN LRKYEMFGGR
60 70 80 90 100
SPSNRIIESI ARKLHEKIGD DMDVILAYKH WNPSIEEAVK GLGSYDNIVA
110 120 130 140 150
IPLFSFYSQN VKDSYLNPLE SALRRYGFSP RLEFVNGLAN SDLFLPMWAN
160 170 180 190 200
IISEDASEDS FYLFDAHSLP APDREEDYLF WLRYSTYKIS QILGLSRSDF
210 220 230 240 250
GFQGGHLGWL GPSIYDVLNR IDASKITVIP ISFLYDHLEI LYDLDYEFRK
260 270 280 290 300
AVEAKGMHYR RVRMPNDSAM MVNMIERAAR SAITHLSGEK INGSIIGQPR

IADTDNGR
Length:308
Mass (Da):35,241
Last modified:March 1, 2001 - v1
Checksum:iBF269B21A9C8F076
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445063 Genomic DNA. Translation: CAC11456.1.
RefSeqiWP_010900740.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11456; CAC11456; CAC11456.
GeneIDi1455934.
KEGGitac:Ta0311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445063 Genomic DNA. Translation: CAC11456.1.
RefSeqiWP_010900740.1. NC_002578.1.

3D structure databases

ProteinModelPortaliQ9HLB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta0311.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC11456; CAC11456; CAC11456.
GeneIDi1455934.
KEGGitac:Ta0311.

Phylogenomic databases

eggNOGiarCOG05373. Archaea.
COG0276. LUCA.
HOGENOMiHOG000112886.
KOiK01772.
OMAiNNIFTEY.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiHEMH_THEAC
AccessioniPrimary (citable) accession number: Q9HLB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: November 11, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.