ID IF2G_THEAC Reviewed; 411 AA. AC Q9HLA7; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 27-MAR-2024, entry version 126. DE RecName: Full=Translation initiation factor 2 subunit gamma {ECO:0000255|HAMAP-Rule:MF_00119}; DE EC=3.6.5.3 {ECO:0000255|HAMAP-Rule:MF_00119}; DE AltName: Full=aIF2-gamma {ECO:0000255|HAMAP-Rule:MF_00119}; DE AltName: Full=eIF-2-gamma {ECO:0000255|HAMAP-Rule:MF_00119}; GN Name=eif2g {ECO:0000255|HAMAP-Rule:MF_00119}; GN OrderedLocusNames=Ta0322; OS Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC OS 15155 / AMRC-C165). OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales; OC Thermoplasmataceae; Thermoplasma. OX NCBI_TaxID=273075; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165; RX PubMed=11029001; DOI=10.1038/35035069; RA Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., RA Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.; RT "The genome sequence of the thermoacidophilic scavenger Thermoplasma RT acidophilum."; RL Nature 407:508-513(2000). CC -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by CC forming a ternary complex with GTP and initiator tRNA. CC {ECO:0000255|HAMAP-Rule:MF_00119}. CC -!- CATALYTIC ACTIVITY: CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.3; CC Evidence={ECO:0000255|HAMAP-Rule:MF_00119}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP- CC Rule:MF_00119}; CC -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain. CC {ECO:0000255|HAMAP-Rule:MF_00119}. CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase CC superfamily. Classic translation factor GTPase family. EIF2G subfamily. CC {ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL445063; CAC11467.1; -; Genomic_DNA. DR RefSeq; WP_010900751.1; NC_002578.1. DR AlphaFoldDB; Q9HLA7; -. DR SMR; Q9HLA7; -. DR STRING; 273075.gene:9571540; -. DR PaxDb; 273075-Ta0322; -. DR EnsemblBacteria; CAC11467; CAC11467; CAC11467. DR GeneID; 1455943; -. DR KEGG; tac:Ta0322; -. DR eggNOG; arCOG01563; Archaea. DR HOGENOM; CLU_027154_0_1_2; -. DR InParanoid; Q9HLA7; -. DR OrthoDB; 7798at2157; -. DR Proteomes; UP000001024; Chromosome. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule. DR GO; GO:0003924; F:GTPase activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule. DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. DR GO; GO:0000049; F:tRNA binding; IEA:InterPro. DR CDD; cd01888; eIF2_gamma; 1. DR CDD; cd03688; eIF2_gamma_II; 1. DR CDD; cd15490; eIF2_gamma_III; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR Gene3D; 2.40.30.10; Translation factors; 2. DR HAMAP; MF_00119; eIF_2_gamma; 1. DR InterPro; IPR015256; eIF2g_C. DR InterPro; IPR044127; eIF2g_dom_2. DR InterPro; IPR044128; eIF2g_GTP-bd. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR005225; Small_GTP-bd_dom. DR InterPro; IPR000795; T_Tr_GTP-bd_dom. DR InterPro; IPR022424; TIF2_gsu. DR InterPro; IPR009000; Transl_B-barrel_sf. DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C. DR NCBIfam; TIGR03680; eif2g_arch; 1. DR NCBIfam; TIGR00231; small_GTP; 1. DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1. DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1. DR Pfam; PF09173; eIF2_C; 1. DR Pfam; PF00009; GTP_EFTU; 1. DR PRINTS; PR00315; ELONGATNFCT. DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR SUPFAM; SSF50447; Translation proteins; 1. DR PROSITE; PS51722; G_TR_2; 1. PE 3: Inferred from homology; KW GTP-binding; Hydrolase; Initiation factor; Magnesium; Metal-binding; KW Nucleotide-binding; Protein biosynthesis; Reference proteome. FT CHAIN 1..411 FT /note="Translation initiation factor 2 subunit gamma" FT /id="PRO_0000137465" FT DOMAIN 9..201 FT /note="tr-type G" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT REGION 18..25 FT /note="G1" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT REGION 46..50 FT /note="G2" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT REGION 88..91 FT /note="G3" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT REGION 144..147 FT /note="G4" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT REGION 179..181 FT /note="G5" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT BINDING 21..26 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT BINDING 21 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT BINDING 25 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT BINDING 46 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT BINDING 48 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT BINDING 144..147 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" FT BINDING 179..181 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00119" SQ SEQUENCE 411 AA; 44859 MW; CD27B96869210EC9 CRC64; MISKLKMPQP SVNIGMVGHV DHGKSTLTLA LTGTKTDTHS EEIKRGISIK LGYADTPIYR CYDSSGNVHY TREKGENCDL ERVISIVDAP GHETLMATML SGSALMNGAL LVIAANEHCP QPQTREHLTA LEIMGIKNII IVQNKIDLVT RERAIESYRE IKNFVKGSIA ENAPIIPVSA YHSTNIDALF EAIEKYIPSP KFNENDDPIM YIARSFDINR PGTPVSELKG GVIGGSLTQG EFALGDEIEI VPGIQTTKGN KTVWNNVTTE VVSLMAGKYS YDRIRPGGLA AIGTKLDPFL TKGDAFTGRI AGHVGKVPPV AFSMRLESHL LKRVVGSDQE LNVEPIRPKE TLMFTVATAN TVGVVNAMKG SEIEVSLKYP VAAFNGMRVA IGRRVMNRWR LIGYGIIQSL E //