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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi88 – 92GTPBy similarity5
Nucleotide bindingi144 – 147GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTACI273075:G1GT7-340-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gamma
Alternative name(s):
aIF2-gamma
eIF-2-gamma
Gene namesi
Name:eif2g
Ordered Locus Names:Ta0322
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374651 – 411Translation initiation factor 2 subunit gammaAdd BLAST411

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.By similarity

Protein-protein interaction databases

STRINGi273075.Ta0322

Structurei

3D structure databases

ProteinModelPortaliQ9HLA7
SMRiQ9HLA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 201tr-type GAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 25G1By similarity8
Regioni46 – 50G2By similarity5
Regioni88 – 91G3By similarity4
Regioni144 – 147G4By similarity4
Regioni179 – 181G5By similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01563 Archaea
COG5257 LUCA
HOGENOMiHOG000229292
KOiK03242
OMAiCPQPQTK
OrthoDBiPOG093Z03P8

Family and domain databases

CDDicd15490 eIF2_gamma_III, 1 hit
HAMAPiMF_00119 eIF_2_gamma, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR022424 TIF2_gsu
IPR015256 TIF2_gsu_C
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
PfamiView protein in Pfam
PF09173 eIF2_C, 1 hit
PF00009 GTP_EFTU, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03680 eif2g_arch, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HLA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISKLKMPQP SVNIGMVGHV DHGKSTLTLA LTGTKTDTHS EEIKRGISIK
60 70 80 90 100
LGYADTPIYR CYDSSGNVHY TREKGENCDL ERVISIVDAP GHETLMATML
110 120 130 140 150
SGSALMNGAL LVIAANEHCP QPQTREHLTA LEIMGIKNII IVQNKIDLVT
160 170 180 190 200
RERAIESYRE IKNFVKGSIA ENAPIIPVSA YHSTNIDALF EAIEKYIPSP
210 220 230 240 250
KFNENDDPIM YIARSFDINR PGTPVSELKG GVIGGSLTQG EFALGDEIEI
260 270 280 290 300
VPGIQTTKGN KTVWNNVTTE VVSLMAGKYS YDRIRPGGLA AIGTKLDPFL
310 320 330 340 350
TKGDAFTGRI AGHVGKVPPV AFSMRLESHL LKRVVGSDQE LNVEPIRPKE
360 370 380 390 400
TLMFTVATAN TVGVVNAMKG SEIEVSLKYP VAAFNGMRVA IGRRVMNRWR
410
LIGYGIIQSL E
Length:411
Mass (Da):44,859
Last modified:March 1, 2001 - v1
Checksum:iCD27B96869210EC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445063 Genomic DNA Translation: CAC11467.1
RefSeqiWP_010900751.1, NC_002578.1

Genome annotation databases

EnsemblBacteriaiCAC11467; CAC11467; CAC11467
GeneIDi1455943
KEGGitac:Ta0322

Similar proteinsi

Entry informationi

Entry nameiIF2G_THEAC
AccessioniPrimary (citable) accession number: Q9HLA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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