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Q9HLA7

- IF2G_THEAC

UniProt

Q9HLA7 - IF2G_THEAC

Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 258GTPBy similarity
    Nucleotide bindingi88 – 925GTPBy similarity
    Nucleotide bindingi144 – 1474GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP
    4. translation initiation factor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor 2 subunit gamma
    Alternative name(s):
    aIF2-gamma
    eIF-2-gamma
    Gene namesi
    Name:eif2g
    Ordered Locus Names:Ta0322
    OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
    Taxonomic identifieri273075 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001024: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411Translation initiation factor 2 subunit gammaPRO_0000137465Add
    BLAST

    Proteomic databases

    PRIDEiQ9HLA7.

    Interactioni

    Subunit structurei

    Heterotrimer composed of an alpha, a beta and a gamma chain.By similarity

    Protein-protein interaction databases

    STRINGi273075.Ta0322.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HLA7.
    SMRiQ9HLA7. Positions 9-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 201193tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni18 – 258G1By similarity
    Regioni46 – 505G2By similarity
    Regioni88 – 914G3By similarity
    Regioni144 – 1474G4By similarity
    Regioni179 – 1813G5By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5257.
    HOGENOMiHOG000229292.
    KOiK03242.
    OMAiYRSDKED.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00119. eIF_2_gamma.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR022424. TIF2_gsu.
    IPR015256. TIF2_gsu_C.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    [Graphical view]
    PfamiPF09173. eIF2_C. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HLA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISKLKMPQP SVNIGMVGHV DHGKSTLTLA LTGTKTDTHS EEIKRGISIK    50
    LGYADTPIYR CYDSSGNVHY TREKGENCDL ERVISIVDAP GHETLMATML 100
    SGSALMNGAL LVIAANEHCP QPQTREHLTA LEIMGIKNII IVQNKIDLVT 150
    RERAIESYRE IKNFVKGSIA ENAPIIPVSA YHSTNIDALF EAIEKYIPSP 200
    KFNENDDPIM YIARSFDINR PGTPVSELKG GVIGGSLTQG EFALGDEIEI 250
    VPGIQTTKGN KTVWNNVTTE VVSLMAGKYS YDRIRPGGLA AIGTKLDPFL 300
    TKGDAFTGRI AGHVGKVPPV AFSMRLESHL LKRVVGSDQE LNVEPIRPKE 350
    TLMFTVATAN TVGVVNAMKG SEIEVSLKYP VAAFNGMRVA IGRRVMNRWR 400
    LIGYGIIQSL E 411
    Length:411
    Mass (Da):44,859
    Last modified:March 1, 2001 - v1
    Checksum:iCD27B96869210EC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445063 Genomic DNA. Translation: CAC11467.1.
    RefSeqiNP_393802.1. NC_002578.1.
    WP_010900751.1. NC_002578.1.

    Genome annotation databases

    EnsemblBacteriaiCAC11467; CAC11467; CAC11467.
    GeneIDi1455943.
    KEGGitac:Ta0322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445063 Genomic DNA. Translation: CAC11467.1 .
    RefSeqi NP_393802.1. NC_002578.1.
    WP_010900751.1. NC_002578.1.

    3D structure databases

    ProteinModelPortali Q9HLA7.
    SMRi Q9HLA7. Positions 9-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273075.Ta0322.

    Proteomic databases

    PRIDEi Q9HLA7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC11467 ; CAC11467 ; CAC11467 .
    GeneIDi 1455943.
    KEGGi tac:Ta0322.

    Phylogenomic databases

    eggNOGi COG5257.
    HOGENOMi HOG000229292.
    KOi K03242.
    OMAi YRSDKED.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00119. eIF_2_gamma.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR022424. TIF2_gsu.
    IPR015256. TIF2_gsu_C.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    [Graphical view ]
    Pfami PF09173. eIF2_C. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR03680. eif2g_arch. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
      Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
      Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

    Entry informationi

    Entry nameiIF2G_THEAC
    AccessioniPrimary (citable) accession number: Q9HLA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3