Q9HLA7 (IF2G_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor 2 subunit gamma

Alternative name(s):
aIF2-gamma
eIF-2-gamma

Gene names

Name:	eif2g
Ordered Locus Names:	Ta0322

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma › Thermoplasma acidophilum

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA By similarity. HAMAP-Rule MF_00119
Subunit structure	Heterotrimer composed of an alpha, a beta and a gamma chain By similarity.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EIF2G subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Ligand	GTP-binding Nucleotide-binding
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC translational elongation Inferred from electronic annotation. Source: GOC
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: HAMAP translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 411	411	Translation initiation factor 2 subunit gamma HAMAP-Rule MF_00119		PRO_0000137465
Regions
	Nucleotide binding	18 – 25	8	GTP By similarity
	Nucleotide binding	88 – 92	5	GTP By similarity
	Nucleotide binding	144 – 147	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HLA7 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: CD27B96869210EC9	FASTA	411	44,859
	10 20 30 40 50 60 MISKLKMPQP SVNIGMVGHV DHGKSTLTLA LTGTKTDTHS EEIKRGISIK LGYADTPIYR 70 80 90 100 110 120 CYDSSGNVHY TREKGENCDL ERVISIVDAP GHETLMATML SGSALMNGAL LVIAANEHCP 130 140 150 160 170 180 QPQTREHLTA LEIMGIKNII IVQNKIDLVT RERAIESYRE IKNFVKGSIA ENAPIIPVSA 190 200 210 220 230 240 YHSTNIDALF EAIEKYIPSP KFNENDDPIM YIARSFDINR PGTPVSELKG GVIGGSLTQG 250 260 270 280 290 300 EFALGDEIEI VPGIQTTKGN KTVWNNVTTE VVSLMAGKYS YDRIRPGGLA AIGTKLDPFL 310 320 330 340 350 360 TKGDAFTGRI AGHVGKVPPV AFSMRLESHL LKRVVGSDQE LNVEPIRPKE TLMFTVATAN 370 380 390 400 410 TVGVVNAMKG SEIEVSLKYP VAAFNGMRVA IGRRVMNRWR LIGYGIIQSL E

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445063 Genomic DNA. Translation: CAC11467.1.
RefSeq	NP_393802.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HLA7.
SMR	Q9HLA7. Positions 9-408.
ModBase	Search...
Protein-protein interaction databases
STRING	273075.Ta0322.
Proteomic databases
PRIDE	Q9HLA7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAC11467; CAC11467; CAC11467.
GeneID	1455943.
KEGG	tac:Ta0322.
Phylogenomic databases
eggNOG	COG5257.
HOGENOM	HOG000229292.
KO	K03242.
OMA	IAANEPC.
ProtClustDB	PRK04000.
Family and domain databases
HAMAP	MF_00119. eIF-2-gamma.
InterPro	IPR000795. EF_GTP-bd_dom. IPR005225. Small_GTP-bd_dom. IPR022424. TIF2_gsu. IPR015256. TIF2_gsu_C. IPR009001. Transl_elong_EF1A/Init_IF2_C. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF09173. eIF2_C. 1 hit. PF00009. GTP_EFTU. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SUPFAM	SSF50465. Elong_init_C. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR03680. eif2g_arch. 1 hit. TIGR00231. small_GTP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IF2G_THEAC

Accession

Primary (citable) accession number: Q9HLA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program