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Q9HLA7

- IF2G_THEAC

UniProt

Q9HLA7 - IF2G_THEAC

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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 258GTPBy similarity
Nucleotide bindingi88 – 925GTPBy similarity
Nucleotide bindingi144 – 1474GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
  4. translation initiation factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gamma
Alternative name(s):
aIF2-gamma
eIF-2-gamma
Gene namesi
Name:eif2g
Ordered Locus Names:Ta0322
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Translation initiation factor 2 subunit gammaPRO_0000137465Add
BLAST

Proteomic databases

PRIDEiQ9HLA7.

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.By similarity

Protein-protein interaction databases

STRINGi273075.Ta0322.

Structurei

3D structure databases

ProteinModelPortaliQ9HLA7.
SMRiQ9HLA7. Positions 9-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 201193tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni18 – 258G1By similarity
Regioni46 – 505G2By similarity
Regioni88 – 914G3By similarity
Regioni144 – 1474G4By similarity
Regioni179 – 1813G5By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5257.
HOGENOMiHOG000229292.
KOiK03242.
OMAiYRSDKED.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF00009. GTP_EFTU. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HLA7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MISKLKMPQP SVNIGMVGHV DHGKSTLTLA LTGTKTDTHS EEIKRGISIK
60 70 80 90 100
LGYADTPIYR CYDSSGNVHY TREKGENCDL ERVISIVDAP GHETLMATML
110 120 130 140 150
SGSALMNGAL LVIAANEHCP QPQTREHLTA LEIMGIKNII IVQNKIDLVT
160 170 180 190 200
RERAIESYRE IKNFVKGSIA ENAPIIPVSA YHSTNIDALF EAIEKYIPSP
210 220 230 240 250
KFNENDDPIM YIARSFDINR PGTPVSELKG GVIGGSLTQG EFALGDEIEI
260 270 280 290 300
VPGIQTTKGN KTVWNNVTTE VVSLMAGKYS YDRIRPGGLA AIGTKLDPFL
310 320 330 340 350
TKGDAFTGRI AGHVGKVPPV AFSMRLESHL LKRVVGSDQE LNVEPIRPKE
360 370 380 390 400
TLMFTVATAN TVGVVNAMKG SEIEVSLKYP VAAFNGMRVA IGRRVMNRWR
410
LIGYGIIQSL E
Length:411
Mass (Da):44,859
Last modified:March 1, 2001 - v1
Checksum:iCD27B96869210EC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445063 Genomic DNA. Translation: CAC11467.1.
RefSeqiNP_393802.1. NC_002578.1.
WP_010900751.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11467; CAC11467; CAC11467.
GeneIDi1455943.
KEGGitac:Ta0322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445063 Genomic DNA. Translation: CAC11467.1 .
RefSeqi NP_393802.1. NC_002578.1.
WP_010900751.1. NC_002578.1.

3D structure databases

ProteinModelPortali Q9HLA7.
SMRi Q9HLA7. Positions 9-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273075.Ta0322.

Proteomic databases

PRIDEi Q9HLA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC11467 ; CAC11467 ; CAC11467 .
GeneIDi 1455943.
KEGGi tac:Ta0322.

Phylogenomic databases

eggNOGi COG5257.
HOGENOMi HOG000229292.
KOi K03242.
OMAi YRSDKED.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00119. eIF_2_gamma.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view ]
Pfami PF09173. eIF2_C. 1 hit.
PF00009. GTP_EFTU. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiIF2G_THEAC
AccessioniPrimary (citable) accession number: Q9HLA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3