Q9HL34 (Q9HL34_THEAC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase related protein EMBL CAC11548.1

Gene names

Ordered Locus Names:

Ta0406

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the HMG-CoA reductase family. RuleBase RU004268

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU004269
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	coenzyme A metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro hydroxymethylglutaryl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9HL34 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 37CF056F0860D4C4	FASTA	437	47,666
	10 20 30 40 50 60 MCSSGSPTFF YNVSISTSMK TSDVSGFYKL SVDDRIQFVK EFSDLTDDEV SILKKNGSLP 70 80 90 100 110 120 IEKADKIIEN VITTIEMPMG IAVNFRINDR DYLIPMAIEE PSVVAAASNA AKVARKRGGF 130 140 150 160 170 180 RAFATEPIMI GEIQVLDVPA PYSAKIALLE SKQKILDMAN TRSKTLSSMN AGARDLEVEI 190 200 210 220 230 240 FEYPYRMMIV HLIVDVRDAM GANVINSMCE YVAPEIARIT GGRVNLRILS NLTKNRIAYA 250 260 270 280 290 300 SAVFPKEIIG EEAVDSIIEA YHMAAIDIYR AATNNKGIMN GVDAVLIATM NDWRSAEANA 310 320 330 340 350 360 HSYAAMYGYG PLARYEKDAN GDLVGSIEIP MAVGTIGGTT RSIEKARIAM KILGVKDAKE 370 380 390 400 410 420 FSGVLAAVGL AQNFAALRAL ATEGIQRGHM ELHSRNIAMS VGAVGDEIDK VVSRMIEEKN 430 ISMANAQKIL QEIRNKN

References

[1]	"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445064 Genomic DNA. Translation: CAC11548.1.
RefSeq	NP_393884.1. NC_002578.1.
3D structure databases
HSSP	HSSP built from PDB template 1QAY based on UniProtKB P13702.
ProteinModelPortal	Q9HL34.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1457006.
GenomeReviews	Gene locus Ta0406 in contig AL139299_GR.
NMPDR	fig|273075.1.peg.406.
Phylogenomic databases
HOGENOM	HBG477902.
OMA	NNKGIMN.
ProtClustDB	CLSK246007.
Enzyme and pathway databases
BioCyc	TACI273075:TA0406-MONOMER.
Family and domain databases
InterPro	IPR002202. HMG_CoA_Rdtase. IPR004553. HMG_CoA_Rdtase_bac-typ. IPR023074. HMG_CoA_Rdtase_cat. IPR023076. HMG_CoA_Rdtase_CS. IPR009023. HMG_CoA_Rdtase_NAD(P)-bd. IPR009029. HMG_CoA_Rdtase_sub-bd. [Graphical view]
Gene3D	G3DSA:3.30.70.420. G3DSA:3.30.70.420. 1 hit. G3DSA:3.90.770.10. HMG-CoA_red. 2 hits.
Pfam	PF00368. HMG-CoA_red. 1 hit. [Graphical view]
PRINTS	PR00071. HMGCOARDTASE.
SUPFAM	SSF55035. HMG_CoA_NAD_bind. 1 hit. SSF56542. HMG_CoA_sub_bind. 1 hit.
TIGRFAMs	TIGR00532. HMG_CoA_R_NAD. 1 hit.
PROSITE	PS00066. HMG_COA_REDUCTASE_1. 1 hit. PS01192. HMG_COA_REDUCTASE_3. 1 hit. PS50065. HMG_COA_REDUCTASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9HL34_THEAC

Accession

Primary (citable) accession number: Q9HL34

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	September 21, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)