Q9HL05 (COXX_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protoheme IX farnesyltransferase
EC=2.5.1.-

Alternative name(s):
Heme B farnesyltransferase
Heme O synthase

Gene names

Name:	ctaB
Ordered Locus Names:	Ta0435

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group By similarity. HAMAP MF_00154
Pathway	Porphyrin metabolism; heme O biosynthesis; heme O from protoheme: step 1/1. HAMAP MF_00154
Subcellular location	Cell membrane; Multi-pass membrane protein Potential HAMAP MF_00154.
Miscellaneous	Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature By similarity. HAMAP MF_00154
Sequence similarities	Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.

Ontologies

Keywords
Biological process	Heme biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	heme O biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protoheme IX farnesyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Protoheme IX farnesyltransferase HAMAP MF_00154		PRO_0000327200
Regions
	Transmembrane	16 – 36	21	Helical; Potential
	Transmembrane	37 – 57	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	111 – 131	21	Helical; Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Transmembrane	162 – 182	21	Helical; Potential
	Transmembrane	210 – 230	21	Helical; Potential
	Transmembrane	236 – 256	21	Helical; Potential
	Transmembrane	265 – 285	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9HL05 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 3DCCA8D3841C16D6	FASTA	288	32,573
	10 20 30 40 50 60 MTSKAMLYFS YTKPKVWSLL VFVGAIGAVI AIPYFNLHYI SLIVLATIAV MLGSMGAEAT 70 80 90 100 110 120 TNYIDKDIDA VMSRTMKRPL VTGQIKPING LLFGLVLMFL SIAILAAFGK LYAALFMGIG 130 140 150 160 170 180 LFDNVFIYSY LTKRRTPWNI ILGGFSGGFP VVIGWYTVTS KFSILPWFLF LLVVVWIPIH 190 200 210 220 230 240 VWSLAYRYRD DYNRAHVPMM TSIHNDRISA ICISSAAIIL FAFSIIPAFF RVMPMVYMIL 250 260 270 280 ASAIAVPMIF YSIVFVRHPD RKNSLKLFIY SSPYLAIIFV LVLIFRFL

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445064 Genomic DNA. Translation: CAC11577.1.
RefSeq	NP_393913.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HL05.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1456044.
GenomeReviews	Gene locus Ta0435 in contig AL139299_GR.
KEGG	tac:Ta0435.
NMPDR	fig|273075.1.peg.435.
Phylogenomic databases
HOGENOM	HBG656003.
OMA	FDNVFIY.
PhylomeDB	Q9HL05.
ProtClustDB	PRK04375.
Enzyme and pathway databases
BioCyc	TACI273075:TA0435-MONOMER.
Family and domain databases
HAMAP	MF_00154. CyoE_CtaB. [Tree]
InterPro	IPR006369. Protohaem_IX_farnesylTrfase. IPR000537. UbiA_prenyltransferase. [Graphical view]
KO	K02301.
Pfam	PF01040. UbiA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01473. CyoE_ctaB. 1 hit.
PROSITE	PS00943. UBIA. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COXX_THEAC

Accession

Primary (citable) accession number: Q9HL05

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program