Q9HKM6 (GSA_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	hemL
Ordered Locus Names:	Ta0571

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP MF_00375
Cofactor	Pyridoxal phosphate.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP MF_00375
Subcellular location	Cytoplasm Potential HAMAP MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
Sequence caution	The sequence CAC11711.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP MF_00375		PRO_0000120492
Amino acid modifications
	Modified residue	261	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HKM6 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 02450AB01059FA89	FASTA	421	46,430
	10 20 30 40 50 60 MGSKDLFQRG SSLFPMGVNS PVRYFKDYPF YVDNASGSRI YDVDGNEYID YCLAYGPSIL 70 80 90 100 110 120 GHADPDVVRA VRDQAEKGLI YGAPSEAEIR LGDIIRRSSK NIEMMRFTNS GTEATMHAIR 130 140 150 160 170 180 LARAYTGRSI IVKMEGGFHG AHDYSLIRSG SGTLTFGSPS SPGVPEEVAR TVVVGRYNDE 190 200 210 220 230 240 ANIRNIFSQY GSRIAAVITE PIMGNAGVIT PEPGFLEFLR DITQKNGSLL IFDEVITGYR 250 260 270 280 290 300 FAFSPYQDII GIRPDLTTMG KIIGGGMPIG LFGGSADIMK KVSPSGDVYQ SGTFSGNPVT 310 320 330 340 350 360 MAAGFAALKK LQGMDYASLV RRTEKLMNGI DDILAKRKIR HVVNGYRSMF QFFFAESAKN 370 380 390 400 410 420 YDEVMKADRD LYFRIFKRLM NHGVYVPPSQ FETNFVSFAH SDDDISKTIE AFDLSVGEAA K

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445064 Genomic DNA. Translation: CAC11711.1. Different initiation.
RefSeq	NP_394045.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HKM6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1456161.
GenomeReviews	Gene locus Ta0571 in contig AL139299_GR.
KEGG	tac:Ta0571.
NMPDR	fig|273075.1.peg.567.
Phylogenomic databases
HOGENOM	HBG725944.
OMA	IMELIAP.
PhylomeDB	Q9HKM6.
ProtClustDB	PRK00062.
Enzyme and pathway databases
BioCyc	TACI273075:TA0571-MONOMER.
Family and domain databases
HAMAP	MF_00375. HemL_aminotrans_3. [Tree]
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K01845.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. HemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_THEAC

Accession

Primary (citable) accession number: Q9HKM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	July 19, 2004
Last modified:	December 14, 2011
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program